1. Biomedical Engineering Program Opening Session Rob Murphy, MD Professor of Medicine and Biomedical Engineering Director, Center for Global Health Northwestern University Chicago, USA

2. 2 Framework Programs for Global Health Innovation Developing Innovative Interdisciplinary Biomedical Engineering Programs in Africa 1.Partners a.Northwestern University. Among the top five biomedical engineering programs in the United States with very strong presence in South Africa with goal to expand to East and West Africa. b.University of Cape Town. Top ranked university in Africa with one of the oldest biomedical engineering programs (developed CT scanner). Partner of Northwestern for 8 years with joint training program. c.University of Ibadan. Biomedical Engineering Program just starting and one of the key training sites in the new consortium. d.University of Lagos. Biomedical Engineering Program in place for over one year and one of the key training sites in the new consortium. e.Nigerian Institute for Medical Research. Para-statal institute focused on medical research including HIV and Tuberculosis

3. 3 Biomedical Engineering Program: Key Personnel: Leadership 1.Robert Murphy, MD Principal Investigator and Professor of Medicine and Biomedical Engineering, Director – Center for Global Health, Northwestern University 2.Matthew Glucksberg, PhD Co-Program Director, Professor of Biomedical Engineering and Director - Center for Innovation in Global Health Technologies (CIGHT), Northwestern University 3.Tania Douglas, PhD Professor of Biomedical Engineering and Director – Medical Imaging Research Unit, Site Program Director, University of Cape Town

4. 4 Biomedical Engineering Program: Key Personnel: Leadership 3. Adewale Coker, PhD Professor of Environmental Health Engineering, Director of the Biomedical Engineering Program, Site Program Director, University of Ibadan 4.Niyi Osuntoki, PhD Senior Lecturer and Acting Head, Department of Biomedical Engineering and Site Program Director, University of Lagos

5. 5 Biomedical Engineering Program: Key Personnel Northwestern University Kara Palamountain, MBA – Executive Director, Global Health Initiative, Kellogg School of Management David Kelso, PhD – Clinical Professor and founding Director, Center for Innovation in Global Health Technologies Chad Achenbach, MD, MPH – Assistant Professor of Medicine and Biomedical Engineer Ellen Chadwick, MD – Professor of Pediatrics, Associate Director of Pediatric and Maternal HIV Infection Daniel Diermeier, PhD – Professor of Regulation and Competitive Practice, Director Ford Center for Global Citizenship Shannon Galvin, MD – Assistant Professor of Medicine and Associate Director, Center for Global Health

6. 6 Biomedical Engineering Program: Key Personnel Northwestern University Jamie Nicole Jones, MBA, PhD – Clinicial Assistant Professor of Entrepreneurial Practice and Director of Social Entrepreneurship Josh Leonard, PhD, - Assistant Professor of Chemical and Biologic Engineering, Co-Director Graduate Cluster in Biotechnology Robert Linsenmeier, PhD – Professor of Biomedical Engineering, Neurobiology and Ophthalmology, Associate Director for the VanNTH Engineering Research Center in Biomedical Educational Technologies Alicia Loffler, PhD, - Associate Vice President for Research and Executive Director, Innovation and New Venture Office (INVO) Babafemi Taiwo, MBBS – Associate Professor of Medicine and Director of Research in Africa Keith Tyo, PhD – Assistant Professor of Chemical and Biologic Engineering and Co-Director, Recombinant Protein Production Core

7. 7 Biomedical Engineering Program: Key Personnel University of Cape Town Jonathan Blackburn, DPhil – South African Research Chair in Applied & Chemical Sciences and founder of Sense Proteomic and the Centre for Proteomic & Genomic Research (RSA) Willem Hanekom, MB, ChB – Professor and Director, South African Tuberculosis Vaccine Initiative Lucy Linley, MBChB– Neonatologist, Head of Department Neonatology, Mowbray Hospital Mladen Poluta, – Senior Lecturer and Convener, Healthcare Technology Management Program

8. 8 Biomedical Engineering Program: Key Personnel University of Ibadan Isaac Adewale, MD – Professor and Vice Chancellor, Co-Principal Investigator for Medical Education Partnership Initiative Nigeria and APIN PEPFAR Program. David Olaleye, MB, ChB – Professor of Virology and Principal Investigator for Medical Education Partnership Initiative University of Lagos Sade Ogunsola, MB ChB, PhD– Professor of Medical Microbiology and Provost, College of Medicine, Chairman of the WHO Working Group on Infection Prevention and Control curriculum

9. 9 Biomedical Engineering Program: Key Personnel Nigerian Institute for Medical Research Oni Idigbe, PhD – Adjunct Professor of Medicine (Northwestern) and Director of Research and former Director General Innocent Ujah, MBBS, ChB – Professor of Obstetrics and Gynaecology (Jos) and Director General

10. 10 Frameworks BME Program 1.Frameworks Biomedical Engineering Grant The theme of our program involves the development of effective, affordable, and easy to use innovative biomedical devices that can advance diagnostic and treatment approaches that result in improved survival. Our cross-disciplinary approach involves three key areas of research which only together can lead to improved health and survival : 1) biomedical engineering, 2) medical evaluation, and 3) commercialization. This interdisciplinary training program will provide LMIC faculty and students with a unique comprehensive hands-on learning experience focused on developing innovative global health technologies.

11. 11 2. Frameworks Aims AIM 1: Establish new and enhance existing training programs in biomedical engineering in sub-Saharan Africa. Through a combination of classroom, distance learning and field work, faculty and post-graduate students will be trained in identification and development of healthcare technologies appropriate for their local and regional settings. AIM 2: Train biomedical engineers and medical doctors to evaluate newly developed testing and therapeutic devices. Trainees from our partner institutions focused on clinical research have already received valuable training through the existing MEPI and AITRP programs, however research projects utilizing their newly acquired skills have been limited. Selected trainees with biomedical and behavioral science backgrounds in adult and pediatric medicine will receive hands-on mentoring directed towards evaluating the newly developed technologies in AIM 1. AIM 3: Train post graduates from business schools to scale up development and launch new healthcare products. Post-graduates in business will be instructed and mentored in defining the most appropriate medical technologies needed in their countries along with the tools needed to approve, finance, procure, distribute, use and maintain these medical technologies. Frameworks BME Program

12. 12 2. Frameworks Research Plan Frameworks BME Program

13. 13 Planned eLearning Activities 2. Frameworks Distance Learning Components 1: Business Global Health Course. This will be a 10 week course, recorded via Articulate, of Professor Kara Palamountain at the Kellogg School of Management. The course will be put on-line, non-synchronous, and will be offered by CD. Following completion, students will be eligible for field work opportunities. 2: Polycom leadership/executive committee meetings. Key personnel from the partner institutions will meet bimonthly to discuss progress of trainees and development of products and its status. 3: Product presentation and training. Group presentations will be made by product development teams using Articulate or other video format. 4: Presentations of other courses. Live streaming, synchronous and asynchronous can be done for a variety of courses in intellectual property, contract negotiations, patent application procedures among others.

14. Current Solution: Commercial Heating Pad US Standard: Bair Hugger 14 Need | Pediatric Surgery Infant Warmer: US Standard and Current Solution Proposed Solution: JoeyKare CostUS$ 12,000 + $300/usage US$30US$300 ProEffective; safe; approvedProvides heat; inexpensiveEffective regulated heat; safe; no disposables; battery backup; commercial potential ConExpensive; highly electric dependent No safety control; unregulated heat; requires electric More expensive than pad

15. 15 Our Solution | JoeyKare

16. 16 Key Features Temperature Adjustability Temperature Monitoring User Feedback Alarm System Multiple Fail Safes Robust Printed Circuit Board Quick Set-Up Time Efficient Heat Production Easy Maintenance Low Cost Device Temperature: 27 ºC Device Temperature Risen Too High Set Temperature: 33 ºC Maintenance Check Required Low Battery

17. 17 Background: Anal Muscle Stimulator Imperforate anus or high anal atresia occurs in 1:600 to 1:5000 births Treatment is surgical: Posterior sagittal anorectalplasty (PSARP) or pull-through anorectal reconstruction Complications can be debilitating, including fecal incontinence Identification of perianal musculature is critical in order to most effectively place the new anus The Pena Stimulator is effective, however it is very expensive – US$12,000 and generally not available in resource-limited settings

18. MS Nerve Stimulator DS7A PSARP Muscle Locating Electric Stimulator

19. Device Layout

20. MS Nerve Stimulator Test

21. Thank you! 21  Questions?  Interest?  Specific ideas?