1. ELECTRONICALLY EXCITED BICARBONATE AQUEOUS SYSTEMS RESPOND TO «INFORMATIONAL COPIES» OF MEDICAL DRUGS TRANSMITTED VIA INTERNET. Vladimir Voeikov. Lomonosov Moscow State University, Moscow, Russia.

2. All natural aqueous systems contain inorganic carbon in interconvertable forms of carbonates Plasma: 27-28 mM СО 2 + НСО 3 - Cells 19-21 mM СО 2 + НСО 3 - CO 2 (gas)  CO 2 (aq.)  H 2 CO 3  HCO 3 ─  CO 3 2 ─

3. THEY ARE NECESSARY FOR THE BIOSYNTHESIS OF ORGANIC COMPOUNDS (PHOTOSYNTHESIS & CARBOXYLATION) THEY ARE NECESSARY FOR AEROBIC RESPIRATION  At the level of the whole organism,  At the level of a cell,  At the molecular level Deficiency of carbonates in the internal environment of the body results in the suppression of the respiration Carbonates are of the primary importance for the basic vital functions:

4. Respiration: "a slow combustion of carbon and hydrogen, similar in every way to that which takes place in a lighted candle…, Antoine-Laurent de Lavoisier, 1791 Respiration is the major source of free energy for living systems

5. 20-90% of all oxygen consumed by aerobic organisms is utilized through one-electron oxygen reduction! COMBUSTION: sequential one-electron reduction of oxygen O 2 + (e¯ … + e¯ + e¯ + e¯ )+(4H + )   [HO 2 ●; H 2 O 2 ; HO●]   2H 2 O + 8 eV Intermediate products – reactive oxygen species (ROS)

6. CARBONATES participate in respiration: they react with ROS and convert into free radicals and reactive carbon species. Those are more long-lived and selective in their chemical activity than ROS HCO 3  +  OH   CO 3  (strong oxidant) + H 2 O HCO 3  + Н 2 О 2 <  HCO 4  + H 2 O СО 2 + е    CO 2  (strong reducer) Carbonate radicals enter into new reactions, e.g.:  CO 3  + Н 2 О 2  НO 2  + HCO 3   CO 3  + O 2    O 2 + CO 3 2   CO 3  + Fe(II)  CO 3 2  + Fe(III)

7. Currently organic food (carbohydrates and fats) are considered to be exclusive sources of electrons for oxygen reduction – RESPIRATION However, there are many indications that the most abundant source of electrons for oxygen reduction may be represented by WATER.

8. Water irradiated with radio waves (~800-900 MHz) burns John Kanzius, 2007 Water (aq. solution of salts) may burn

9. The principle of “water burning” 4 e ─ + 4H + Pollack’s EZ-water (interfacial gel-like water) Bulk water (disorganized water) O 2  ROS  2H 2 O + Energy

10. Free (high density) energy is generated as a result of conversion of dynamically structured (coherent!) water into disorganized bulk water. nH 2 O (Interfacial water) ≠ nH 2 O (Bulk water) Overall reaction 2H 2 O (IF-water) + O 2  O 2 + 2H 2 O (Bulk water) + (Electronic excitation (“free”) energy)

11. Hermetically closed bicarbonate solutions activated with 0,0005% H 2 O 2 “burn” (emit photons) for many months even in complete darkness. Bicarbonates may promote stable long- term water “burning”

12. An example of H 2 O 2 -activated bicarbonate solution “burning” for more than a year. 20082009 2010 5 mM NaHCO 3 was activated with Н 2 О 2 on October 14, 2008. Photon emission intensity, counts/sec Time, months

13. 13 Using Tiron (ESR probe for superoxide radical (О 2 ─ ●) we observed continuous generation of О 2 ─ ● in bicarbonate solutions ESR spectra of Tiron in the darkness (А ) and under и illumination by white or blue (455 nm) light (B) in NaHCO 3 (5 and 10 мМ) solutions RATE OF SUPEROXIDE PRODUCTION INCREASES ON ILLUMINATION OF BICARBONATE SOLUTIONS АB

14. Emission intensity Counts/sec Time (sec) Reagent “Reagent” added to water Photo multiplier tube Data processing Time series “Reagent”: FeSO 4 (0,1-10 mkM) ± Luminol (0,1-10 mkM) Addition of Fe (II) salts in catalytic quantities to bicarbonate waters results in the development of the wave of Luminol-amplified photon emission from them. This indicates that processes in which Reactive Oxygen Species participate PERMANENTLY go on in bicarbonate waters.

15. Scheme of bicarbonate promoted water oxidation

16. Red/Ox -processes that incessantly proceed in bicarbonate waters compose the web of looped reactions in the course of which reagents are consumed and regenerated. The existence of this web promotes stable non- equilibrium electronically excited state of bicarbonate water that is able to react to subtle external “irritations” Bicarbonates promote stable non- equilibrium state of aqueous systems

17. New Moon 08/08/2002 16:00-18:00 A bottle with natural spring mineral water was opened a week before “zero” time (02/0802002 00:00) Red/Ox processes going on in bicarbonate (here -- spring water) exhibit circadian rhythms. They are sensitive to variations of subtle environmental factors, e.g. to Moon phase.

18. “Energetic activity” of 5 mM sodium bicarbonate solution is sensitive to the fluctuations of the geomagnetic field (“geomagnetic storms”).

19. Amplitudes of luminescence waves induced in a natural bicarbonate are amplified after addition to them hydrated fullerenes (HyFn) even in ultra-low doses.

20. Thus bicarbonate aqueous solutions are highly non-equilibrium, “charged” systems. They are capable to change their behavior in response to subtle external resonant influences. We used natural bicarbonate drinking waters as test systems for evaluation if information related to specific medical drugs may be transmitted via Internet and may affect water properties.

21. TECHNOLOGY OF ELECTRONIC TRANSMISSION OF INFORMATIONAL COPIES OF MEDICAL DRUGS USED BY DST-FOUNDATION. 1. A pill is placed on a CD and illuminated with a laser pointer 2. “Informed” CD is inserted into a CD-ROM of a computer connected to Internet 3. A client chooses a particular drug from the list at the web-site, inserts a clear CD into his computer, clicks on the name of the drug, and several minutes later extracts the CD “informed” with the Electronically Transmitted drug

22. 4. An “informed” CD is used as a stand for a glass with water that 30-60 minutes later becomes an “Informational copy” of the particular drug

23. More information on the technique and available downloads see at the web-site http://www.newpharm.com and in the poster presented at this Conference

24. Experimental setup for study of the effects of ICs of drugs on photon emission from bicarbonate aqueous systems: 1. Vials are filled with bicarbonate drinking water and put on clear CDs or CDs on which “Informational copy” of a drug was electronically transferred. 2. Fe(II) salt is added to water samples to initiate photon emission from it. Intensity of photon emission is registered on a single photon counter.

25. Comparison of water “energy activity” after its incubation for 24 hours on clear CDs and on CDs with “informational copy” of Dexone (Dexametazone).

26. In 5 independent experiments with “informational copies” of Dexone statistically significant difference was observed between photon emission intensity in control water and water incubated on CDs on which “informational copies” of Dexone was loaded. Difference between control and experimental waters could sustain up to 4 days.

27. Comparison of water “energy activity” after its incubation for 24 hours on a clear CD and on a CD with “informational copy” of Arbidol ( Umifenovirum) – antiviral and immunostimulatory drug. Counts/sec Time, sec Arbidol Control

28. Water with “Informational copy” of Arbidol  has immune stimulatory effect on immune deficient mice, while water with “Informational copy” of Dexone  has immunosuppressant effect on mice B.P. Surinov, MD, PhD, Medical radiological scientific center, Ministry of Health of Russia, Obninsk. Arbidol (Umifenovirum) – antiviral and immunostimulatory drug Dexametasone (Dexone) – immunosuppressant and anti-inflammatory

29. Thus, incubation of bicarbonate drinking water on CDs “informed” by electronically transmitted drugs influence the parameters of Red/Ox reactions proceeding in water. Drugs having opposite effects on biological test systems influence parameters of Red/Ox reactions in water in the opposite way.

30. Thank you! http://www.charlottekons.de/

31. Photon emission intensity from H 2 O 2 activated bicarbonate aqueous solutions is sensitive to ultra-low doses of biologically active compounds.

32. Comparison of photon emission from one and the same sample during a week preceding Moon eclipse and a week following Moon eclipse.

33. (H 3 O 2 ─ ) n Liquid crystalline structures in interfacial water built of monomers [(Н 3 О 2 ) — ] n (after G.Pollack, 2010), possessing electron donating properties Quantity: Hydrogen Oxygen Charge: Hydrogen Oxygen Charge of one ring = -1

34. 34 Hypothetic scheme of free radical reactions in aqueous bicarbonate solutions Tiron ESR signal Products + hv

35. 35 When H 2 O 2 is added

36. The fundamental process that may underlie photon emission from bicarbonate solutions is WATER BURNING. Burning of carbon is in fact WATER BURNING: «…the carbone attracts the oxygen of the water, and forms carbonic acid, while the hydrogen of the water unites with oxygen of the vital air, and forms a new quantity of water equal to that decomposed». О Н Н О Н Н С +  СO 2 + 4H;4H + O 2  2H 2 O Elizabeth Fulhame. 1794. … G.B. Dixon 1877. … John Kanzius. 2005. …

37. If СО 2 is present in biphasic aqueous system (IF-water/Bulk water): (Bi)carbonates will promote water oxidation (“water burning”) being a source of high density free energy, A lot of active particles will emerge in this system: ─О─С  О+, HO●, СО 3 ─ ●, О 2 ─ ●, ●С  О+, HOOCO 2 ─, Н 2 С=О… (organics!) If N 2 is present it will be excited, ionized, and opportunity for emergence of complex organic compounds including polymers will arise Н 2 С=О + NH 3  amino acids, heterocyclic compounds including nucleic acid bases

38. O 2 + 2H 2 O (Bulk water) + Free energy CO 2 HCO 3 ─ CO 3 ─ ● C n O n (H n ) H2O2H2O2 HO● H 2 O 3(4) Carbonates catalyze water burning 2H 2 O (IF-water) + O 2 +  The overall reaction

39. n.s. P<0.05 P<0.01 P<0.05 increase decrease CD with IC-Aspirin promotes increase and CD with IC-Trimetazidine (Preductal®) promotes decrease in intensity of ROS-dependent reactions in drinking water