1. DVT/PE/VTE Adrian Burger 26 April 2007

2. Virchow Triad 3 primary components: venous stasis injury to the intima changes in the coagulation properties of the blood

3. Thrombus Originates as a platelet nidus in the region of venous valves located in the veins of the lower extremities. Further growth occurs by accretion of platelets and fibrin and progression to red fibrin thrombus, which may either break off and embolize or result in total occlusion of the vein.

4. Pulmonary Emboli From the thrombi originating in the deep venous system of the lower extremities Rarely, they may originate in the pelvic, renal, or upper extremity veins and the right heart chambers. Large thrombi lodge at the bifurcation of the main pulmonary artery or the lobar branches, accumulate and may cause haemodynamic compromise. Smaller thrombi continue distally, occluding smaller vessels in the lung periphery. These are more likely to produce pleuritic chest pain by initiating an inflammatory response adjacent to the parietal pleura. Most pulmonary emboli are multiple, and the lower lobes are involved more commonly than the upper lobes

5. Anatomy

6. Risk Factors age - as people over 40 are at greater risk of DVT a past history of DVT a family history of DVT an inherited condition that makes the blood more likely to clot than usual immobility obesity recent surgery or an injury, especially to the hips or knees pregnancy having recently had a baby having cancer and its treatments taking a contraceptive pill that contains oestrogen - but most modern pills contain a low-dose, which increases the risk by an amount that is acceptable for most women hormone replacement therapy (HRT) - but for many women, the other benefits outweigh the increase in risk of DVT treatment for other circulation or heart problems

7. Why Treat? The consequences of venous thrombosis: Distal DVT }Symptomatic and Asymptomatic Proximal DVT Symptomatic PE 30% Asymptomatic PE 40% Fatal PE Post-phlebitic syndrome

8. Wells Criteria

9. Wells Low risk (-2-0) = 3-13% Moderate risk (1-2) = 17-38% High risk (>2)= 60-75% Clinical Intuition = 38% underestimation

10. Special Investigations TestAdvantagesDisadvantages Contrast“Gold standard”Invasive VenographySensitivity approaches 100%Requires specialized equipment Easily interpretableRare, but serious side effects Magnetic ResonanceHighly accurateExpensive ImagingSafe during pregnancyNot readily available Non-invasive Computed TomographyNon-invasiveLimited data Can diagnose pelvic DVT Concurrently exclude PE UltrasonographyHighly accurateNot accurate for calf or pelvic DVT Non-invasiveComplete study is time consuming D-DimerRapid laboratory studyOnly used to rule-out DVT Can aide in exclusion of DVT

11. 15 DVT Studies 8 PE Studies High Risk Prevalence 17-85% Moderate Risk Prevalence 0-38% Low Risk Prevalence 0-13% High Risk Prevalence 38-78% Moderate Risk Prevalence 16-28% Low Risk Prevalence 1-3%

12. Clinical Decision Rule + D-dimer? 15 Studies Low Probability + Neg D-dimer 0.5% 3 month incidence Moderate Probability + Neg D-dimer 3.5% 3 month incidence High Probability + Neg D-dimer 21.4% month incidence

13. D-dimer Alone Review of 5 systematic reviews Latex Turbidimetric and ELISA Review of 78 studies ELISA & Quantitative Rapid ELISA Cutoff 500ng/ml Varies with age and co-morbidity Low to Moderate Probability patients

14. D-dimer Alone PE ELISA 95% Sensitivity 45% Specificity Turbidimetric Assay 93% Sensitivity 51% Specificity DVT or PE ELISA 95% Sensitivity 40% Specificity Quant Rapid ELISA 97% Sensitivity 50% Specificity

15. Ultrasound 8 Systematic Reviews Contrast venography as gold standard B-mode US (compression US) Duplex US – with or without colour Doppler Symptomatic/Asymptomatic/Both Proximal/Distal/Both

16. US

17. Ultrasound?

18. Ultrasound Good sensitivity Symptomatic, proximal 93-100% Good specificity all round 97-100% Poor for - asymptomatic 47-62% - upper extremity 56-100% - calf 25-93%

19. Ultrasound for DVT High Sens and Spec for proximal lower extremity Low Sens but High Spec for high risk asymptomatic patients Poor Sens for Calf Vein Follow-up 7 days if symptomatic and first US negative especially if moderate to high risk

20. CTA for PE?

21. CTA 10 Systematic Reviews Old helical CT scanners PA comparison only in 4 (80-86% Sens) Sensitivities 66-93% Specificities 89-98% At best 90% sensitivity compared with PA Specificity better at 95%

22. Conclusions Clinical Prediction Score Establish pre-test probability D-dimer + Clinical Score High negative predictive value No further studies needed if low risk and neg D-dimer in isolation ELISA and Rapid quantitative ELISA Young patients, short duration

23. Conclusion Ultrasound Good for symptomatic, proximal lower extremity DVT Poor for asymptomatic, distal, upper extremity CTA Newer multislice CT up to 100% sensitive

24. DVT Algorithm

25. References Ann Intern Med. 2007 Feb 6;146(3):I43. Epub 2007 Jan 29 Ann Fam Med. 2007 Jan/Feb Vol 5 No 1 Ann Emerg Med. 2003;42:124-135 Emerg Med Clin North Am. Vol 22 No 3 Aug 2004