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Ras-Raf-MAPK SHCGrb2SOS1 P P P Raf1 P MEK2 P MEK1 P Grb2, growth factor receptor-bound protein 2 Ras ERK2 ERK1.

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Presentation on theme: "Ras-Raf-MAPK SHCGrb2SOS1 P P P Raf1 P MEK2 P MEK1 P Grb2, growth factor receptor-bound protein 2 Ras ERK2 ERK1."— Presentation transcript:

1 Ras-Raf-MAPK SHCGrb2SOS1 P P P Raf1 P MEK2 P MEK1 P Grb2, growth factor receptor-bound protein 2 Ras ERK2 ERK1

2 SHCGrb2SOS1 P P P Raf1 P MEK2 P ERK2 P P ERK1 P P MEK1 P Transcription factors Grb2, growth factor receptor-bound protein 2; SRF, serum response factor Ras SRF Transcription Ras-Raf-MAPK

3 Attivazione costitutiva di Ras-Raf-MAPK Raf1 P MEK2 P ERK2 P P ERK1 P P MEK1 P SRF Ras Transcription

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12 Zarnestra (Tipifarnib, R115777) Sarasar (Lonafarnib, SCH66336)

13 EVIDENCE FOR A Ras-INDEPENDENT EFFECT FOR FTIs Lack of correlation between susceptibility and Ras status Differences in the kinetics of development of the effects Inhibition of K-Ras- and N-Ras-dependent cell growth

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16 REOVIRUS (Respiratory Enteric Orphan Virus)

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18 Attivazione costitutiva di Ras-Raf-MAPK Raf1 P MEK2 P ERK2 P P ERK1 P P MEK1 P SRF Ras Transcription

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20 SORAFENIB (Nexavar®): Low molecular weight inhibitor of VEGFR, PDGFR, KIT, RET and Raf-1 kinase activity

21 Mechanism of action of sorafenib


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