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[Bejerano Spr06/07] 1 TTh 11:00-12:15 in Clark S361 Profs: Serafim Batzoglou, Gill Bejerano TAs: George Asimenos, Cory McLean.

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Presentation on theme: "[Bejerano Spr06/07] 1 TTh 11:00-12:15 in Clark S361 Profs: Serafim Batzoglou, Gill Bejerano TAs: George Asimenos, Cory McLean."— Presentation transcript:

1 http://cs273a.stanford.edu [Bejerano Spr06/07] 1 TTh 11:00-12:15 in Clark S361 Profs: Serafim Batzoglou, Gill Bejerano TAs: George Asimenos, Cory McLean

2 http://cs273a.stanford.edu [Bejerano Spr06/07] 2 Lecture 13 Insulators in the Human Genome Discuss Project Co-option

3 http://cs273a.stanford.edu [Bejerano Spr06/07] 3 Insulators: A Reminder

4 http://cs273a.stanford.edu [Bejerano Spr06/07] 4 CTCF [Ohlsson et al., 2001]

5 http://cs273a.stanford.edu [Bejerano Spr06/07] 5 The Glass Ceiling [Ohlsson et al., 2001]

6 http://cs273a.stanford.edu [Bejerano Spr06/07] 6 ChIP-chip reminder

7 http://cs273a.stanford.edu [Bejerano Spr06/07] 7 Breaking the Glass Ceiling [Kim et al., 2007]

8 http://cs273a.stanford.edu [Bejerano Spr06/07] 8 A known locus

9 http://cs273a.stanford.edu [Bejerano Spr06/07] 9 More & less interesting correlations

10 http://cs273a.stanford.edu [Bejerano Spr06/07] 10 Outliers

11 http://cs273a.stanford.edu [Bejerano Spr06/07] 11 Consensus!

12 http://cs273a.stanford.edu [Bejerano Spr06/07] 12 Not all are captured

13 http://cs273a.stanford.edu [Bejerano Spr06/07] 13 From in vitro to in silico [Xie et al., 2007]

14 http://cs273a.stanford.edu [Bejerano Spr06/07] 14

15 http://cs273a.stanford.edu [Bejerano Spr06/07] 15

16 http://cs273a.stanford.edu [Bejerano Spr06/07] 16

17 http://cs273a.stanford.edu [Bejerano Spr06/07] 17

18 http://cs273a.stanford.edu [Bejerano Spr06/07] 18 Genomic Distribution of Ultraconserved Elements exonic non possibly

19 http://cs273a.stanford.edu [Bejerano Spr06/07] 19 Uniquely Abundant in Coelacanth ? x Upto 80%id between Coelacanth instances and some human instances, inc uc.338. 100 diverged copies in a Gigabase 60 highly similar copies in a Megabase

20 http://cs273a.stanford.edu [Bejerano Spr06/07] 20 Repeats / obile Elements ("selfish DNA") Human Genome: 3*10 9 letters 1.5% known function >50% junk

21 http://cs273a.stanford.edu [Bejerano Spr06/07] 21 The LF SINE (for Lobefin Fish / “Living Fossil”) Reconstruction out back target site duplications not similar to any known repeat

22 http://cs273a.stanford.edu [Bejerano Spr06/07] 22 To Be Continued….


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