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[Bejerano Aut07/08] 1 MW 11:00-12:15 in Redwood G19 Profs: Serafim Batzoglou, Gill Bejerano TA: Cory McLean.

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Presentation on theme: "[Bejerano Aut07/08] 1 MW 11:00-12:15 in Redwood G19 Profs: Serafim Batzoglou, Gill Bejerano TA: Cory McLean."— Presentation transcript:

1 http://cs273a.stanford.edu [Bejerano Aut07/08] 1 MW 11:00-12:15 in Redwood G19 Profs: Serafim Batzoglou, Gill Bejerano TA: Cory McLean

2 http://cs273a.stanford.edu [Bejerano Aut07/08] 2 Lecture 13 Insulators in the Human Genome Regulatory Potential

3 http://cs273a.stanford.edu [Bejerano Aut07/08] 3 Insulators: A Reminder

4 http://cs273a.stanford.edu [Bejerano Aut07/08] 4 CTCF [Ohlsson et al., 2001]

5 http://cs273a.stanford.edu [Bejerano Aut07/08] 5 The Glass Ceiling [Ohlsson et al., 2001]

6 http://cs273a.stanford.edu [Bejerano Aut07/08] 6 ChIP-chip reminder

7 http://cs273a.stanford.edu [Bejerano Aut07/08] 7 Breaking the Glass Ceiling [Kim et al., 2007]

8 http://cs273a.stanford.edu [Bejerano Aut07/08] 8 A known locus

9 http://cs273a.stanford.edu [Bejerano Aut07/08] 9 More & less interesting correlations

10 http://cs273a.stanford.edu [Bejerano Aut07/08] 10 Outliers

11 http://cs273a.stanford.edu [Bejerano Aut07/08] 11 Consensus!

12 http://cs273a.stanford.edu [Bejerano Aut07/08] 12 Not all are captured

13 http://cs273a.stanford.edu [Bejerano Aut07/08] 13 From in vitro to in silico [Xie et al., 2007]

14 http://cs273a.stanford.edu [Bejerano Aut07/08] 14

15 http://cs273a.stanford.edu [Bejerano Aut07/08] 15

16 http://cs273a.stanford.edu [Bejerano Aut07/08] 16

17 http://cs273a.stanford.edu [Bejerano Aut07/08] 17

18 http://cs273a.stanford.edu [Bejerano Aut07/08] 18 Predicting Distal Elements

19 http://cs273a.stanford.edu [Bejerano Aut07/08] 19

20 http://cs273a.stanford.edu [Bejerano Aut07/08] 20

21 http://cs273a.stanford.edu [Bejerano Aut07/08] 21 ChIP-Seq

22 http://cs273a.stanford.edu [Bejerano Aut07/08] 22

23 http://cs273a.stanford.edu [Bejerano Aut07/08] 23 Example: NRSF

24 http://cs273a.stanford.edu [Bejerano Aut07/08] 24 With original motif

25 http://cs273a.stanford.edu [Bejerano Aut07/08] 25 Pancreatic Islet beta cell-specification GRN

26 http://cs273a.stanford.edu [Bejerano Aut07/08] 26 …

27 http://cs273a.stanford.edu [Bejerano Aut07/08] 27


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