1. BIPN 148 Lecture 12

3. CaMKII delivers GluR1 to silent synapses GluR2(R586E)-non-conducting GluR1(Q582E)-non-conducting GluR2(R586Q)-conducting, rectifying Shi and Malinow, 2001

4. GluR1-C tail expression inhibits LTP

5. Role of GluR1 trafficking in fear conditioning: Physiology of GluR1 transfected neurons in Amygdala

6. Expression of GluR1-C inhibits plasticityin Amygdala

7. Expression of GluuR1-C inhibits fear conditioning

8. Interaction Between AMPAR, Stargazin, and PSD-95 Stargazin interacts with AMPA receptors in an intracellular compartment in the cell and promotes their delivery to the cell surface. The carboxyl terminus of stargazin binds specifically to the anchor protein PSD-95 and mediates recruitment of the stargazin-AMPA receptor complex to postsynaptic sites.

9. Loss of AMPA current in stargazer mutant mice (recordings from cerebellar granule neurons)

10. Stargazin enhances glutamate response

11. Stargazin increases AMPA channel openings

12. Stargazin increases surface GluR1 expression

13. Stargazin restores AMPA currents in mutants (Stargazin-deltaC restores surface expression, but not synaptic targeting)

14. Stargazin-deltaC inhibits AMPA responses

15. PSD95 and Stargazin have distinct effects on synaptic responses and surface AMPA receptors

16. Effect of GluR1 S887A (C tail) on LTP