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Chromosome Geography Lecture. The Chromosome as a Polymer Blob b=2P.

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Presentation on theme: "Chromosome Geography Lecture. The Chromosome as a Polymer Blob b=2P."— Presentation transcript:

1 Chromosome Geography Lecture

2 The Chromosome as a Polymer Blob b=2P

3 Chromosome Geography @ Caltech Sturtevant and Morgan Benzer

4 Chromosome Geography: Genomic vs. physical position Cremer and Cremer Lucy Shapiro

5 Fluorescence In-Situ Hybridization (FISH) http://www.microscopyu.com/articles/fluorescence/insitu/brennerinsitu.html

6 Schemes for Mapping Chromosome Geography Gitai et al, 2005

7 Yokota et al, 1995 Quantifying the Geography Gasser, Science 2002

8 Quantifying the Geography Heun, Gasser, Science 2001 Bystricky, Gasser, PNAS 2004

9 Quantifying the Geography Sachs et al.

10 The Immune System

11 Kees Murre, UCSD

12 oriC I oriC II x y Probability x y Replication origins are confined! (Theriot et al.) Chromosome Geography in Vibrio

13 Models for Chromosome Segregation Gitai et al, 2005

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