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Monday, August 13, 2007NASUG 2007 METAANALYTIC INTEGRATION OF DIAGNOSTIC ACCURACY STUDIES IN STATA Ben A. Dwamena, MD Department of Radiology (Nuclear.

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Presentation on theme: "Monday, August 13, 2007NASUG 2007 METAANALYTIC INTEGRATION OF DIAGNOSTIC ACCURACY STUDIES IN STATA Ben A. Dwamena, MD Department of Radiology (Nuclear."— Presentation transcript:

1 Monday, August 13, 2007NASUG 2007 METAANALYTIC INTEGRATION OF DIAGNOSTIC ACCURACY STUDIES IN STATA Ben A. Dwamena, MD Department of Radiology (Nuclear Medicine)

2 Monday, August 13, 2007NASUG 2007 WHY META-ANALYSIS?

3 Monday, August 13, 2007NASUG 2007 WHY META-ANALYSIS?

4 Monday, August 13, 2007NASUG 2007 2 X 2 TABLE FOR SINGLE STUDY

5 Monday, August 13, 2007NASUG 2007 THESHOLD EFFECT AND ROC

6 Monday, August 13, 2007NASUG 2007 VARIATION IN THRESHOLD VS ACCURACY

7 Monday, August 13, 2007NASUG 2007 TRADITIONAL MODEL

8 Monday, August 13, 2007NASUG 2007 EXAMPLE DATA

9 Monday, August 13, 2007NASUG 2007

10 Monday, August 13, 2007NASUG 2007

11 Monday, August 13, 2007NASUG 2007

12 Monday, August 13, 2007NASUG 2007 LIMITATIONS OF SROC MODEL

13 Monday, August 13, 2007NASUG 2007 BIVARIATE MIXED-EFFECTS BINOMIAL REGRESSION MODEL

14 Monday, August 13, 2007NASUG 2007 BIVARIATE MIXED-EFFECTS BINOMIAL REGRESSION MODEL

15 Monday, August 13, 2007NASUG 2007 BIVARIATE MIXED-EFFECTS BINOMIAL REGRESSION MODEL

16 Monday, August 13, 2007NASUG 2007 BIVARIATE MIXED-EFFECTS BINOMIAL REGRESSION MODEL

17 Monday, August 13, 2007NASUG 2007 BIVARIATE MIXED-EFFECTS BINOMIAL REGRESSION MODEL

18 Monday, August 13, 2007NASUG 2007 BIVARIATE MIXED-EFFECTS BINOMIAL REGRESSION MODEL

19 Monday, August 13, 2007NASUG 2007 BINOMIAL REGRESSION MODEL XTMELOGIT CODE

20 Monday, August 13, 2007NASUG 2007 BINOMIAL REGRESSION MODEL GLAMM CODE

21 Monday, August 13, 2007NASUG 2007 EXAMPLE DATASET: Axillary PET Scan in Primary Breast Cancer

22 Monday, August 13, 2007NASUG 2007 SYNTAX FOR midas

23 Monday, August 13, 2007NASUG 2007 QUALITY ASSESSMENT midas tp fp fn tn prodesign ssize30 fulverif testdescr refdescr subjdescr /// report brdspect blinded, id(author) year(year) qualib

24 Monday, August 13, 2007NASUG 2007 ROC PLANE midas tp fp fn tn, id(author) year(year) es(x) rocp

25 Monday, August 13, 2007NASUG 2007 CHI-PLOT midas tp fp fn tn, id(author) year(year) ms(0.75) chip

26 Monday, August 13, 2007NASUG 2007 BIVARIATE BOXPLOT midas tp fp fn tn, id(author) year(year) ms(0.75) bivbox

27 Monday, August 13, 2007NASUG 2007 SUMMARY RESULTS midas tp fp fn tn, id(author) year(year) es(x) ms(0.75) sumstats

28 Monday, August 13, 2007NASUG 2007 SUMMARY RESULTS: midas tp fp fn tn, id(author) year(year) ms(0.75) es(x) sumstats

29 Monday, August 13, 2007NASUG 2007 SUMMARY ROC midas tp fp fn tn, es(x) ms(0.75) plot sroc1

30 Monday, August 13, 2007NASUG 2007 SUMMARY ROC midas tp fp fn tn, es(x) ms(0.75) plot sroc2

31 Monday, August 13, 2007NASUG 2007 FOREST PLOT midas tp fp fn tn, id(author) year(year) es(x) ms(0.75) ford for(dss)

32 Monday, August 13, 2007NASUG 2007 FOREST PLOT midas tp fp fn tn, id(author) year(year) es(x) ms(0.45) for(dss)

33 Monday, August 13, 2007NASUG 2007 FUNNEL PLOT midas tp fp fn tn, ms(0.75) fun

34 Monday, August 13, 2007NASUG 2007 FUNNEL PLOT ASYMMETRY TEST midas tp fp fn tn, pubb

35 Monday, August 13, 2007NASUG 2007 CONDITIONAL PROBABILITY PLOT midas tp fp fn tn, es(x) pddam(p)

36 Monday, August 13, 2007NASUG 2007 UNCONDITIONAL PREDICTIVE VALUES midas tp fp fn tn, ms(0.75) es(x) pddam(r)

37 Monday, August 13, 2007NASUG 2007 FAGAN’S NOMOGRAM I midas tp fp fn tn, es(x) fagan

38 Monday, August 13, 2007NASUG 2007 FAGAN’S NOMOGRAM II midas tp fp fn tn, es(x) fagan prior(.20)

39 Monday, August 13, 2007NASUG 2007 LIKELIHOOD RATIO SCATTERGRAM midas tp fp fn tn, es(x) lrmat

40 Monday, August 13, 2007NASUG 2007 UNIVARIABLE META-REGRESSION midas tp fp fn tn prodesign brdspect blinded, covars

41 Monday, August 13, 2007NASUG 2007 WORK-IN-PROGRESS Extending bivariate model to assess: Publication bias using association- marginal modeling Influencial Studies Heterogeneity using ICCs Nonparametric modeling of random effects etc

42 Monday, August 13, 2007NASUG 2007 THANK YOU FOR YOUR ATTENTION  QUESTIONS?  SUGGESTIONS  COMMENTS

43 Monday, August 13, 2007NASUG 2007 ACKNOWLEDGEMENTS

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