1. Biomedical Research Core Facilities Cassandra Wong Administrative Director Nov. 1, 2011

2. BRCF Purpose To provide advanced, state-of-the-art research services to the research community, via centralized instrumentation and scientific expertise. BRCF Administration: To manage the lifecycle of the individual core facility, using financial, equipment and personnel investments, so that each core can reach their full potential.

3. Core facilities….  Leverage large scientific equipment investments on a school-wide and institutional basis  Create a wide area of access for investigators  Increase efficiency of services while reducing overall cost of services  Drive scientific research as active partners with investigators  Enhance faculty recruitment efforts

4. Products and Services BRCF Cores: Biomedical Research Store Biosafety Containment Core DNA Sequencing and Microarray Core Flow Cytometry Core Protein Structure Core Sample Preservation Freezer Facility Transgenic Animal Model Core Incoming BRCF Cores (FY12): Bioinformatics Core Microscopy and Image Analysis Core Vector Core

5. BRCF Customers Internal U-M Customers: Over 700 Principal Investigator-led laboratories served in FY11  Laboratories spread over 130 Dept IDs  7 schools and colleges  5 campuses (including Flint and Dearborn) External Customers: For FY11, billed 60 institutions -  from 22 states  from 6 countries outside of U.S.  8 corporations

6. BRCF and U-M Departments/Offices Financial Operations –Office of Financial Analysis –Procurement and Accounts Payable –Accounts Receivable –Sponsored Programs –Tax Department Cancer Center Michigan Diabetes Research and Training Program (MDRTC) Michigan Gastrointestinal Peptide Research Center (MGPRC) Biological Chemistry (faculty appointments) Internal Medicine – MMG, Pulmonary, Rheumatology (faculty appt; new BRCF core) Microbiology and Immunology (faculty appointment) NCRC (new core locations) Computational Medicine and Bioinformatics (new BRCF core) Cellular and Developmental Biology (new BRCF core) MSA Units (Grants Office, MSIS, OoR)

7. Staffing Trends In FY11, BRCF handled over $10.7 million in recharges, 31 shortcodes, 48 staff/faculty for six cores Historically understaffed with less than 3 FTE (including Director) The Dean has invested to provide 3 FTE to improve and establish infrastructure to accommodate more cores (Assoc Dir, external billing, account reconciliation) and implement new initiatives

8. Current Tactical Initiatives Capital equipment fund for core instrumentation –Replace obsolete equipment –Introduce strategic new technology –Requests evaluated by BRCF Capital Equipment Committee IT systems for billing (with MSIS) –Enhanced capability of adding new cores –Improved efficiency of existing core billing –Provide an IT framework for non-BRCF cores Financial re-structure/remapping –Current structure created for small number of small cores BRCF-wide customer relations and communications effort Evaluating potential cores to bring into BRCF group

9. Opportunities for Collaboration & Synergy Characteristics of a Medical School Core:  Serves a broad range of faculty where a majority of users are from multiple departments rather than a single department  Enables better science by operationally being with the U-M (UMMS) walls or systems (scientific impact)  Has Core leadership dedicated to the strategic scientific vision of the core, and translating that vision into a business operation  Meets a regulatory requirement for the University  Operation is financially self-sustaining

10. Thank You

11. Appendix

12. Organizational Structure Cassandra Wong, Administrative Director Christina Stilson Biomedical Research Store Steven King, PhD, Biosafety Containment Core Tom Moore, PhD Dave Adams Flow Cytometry Core Robert Lyons, PhD DNA Sequencing and Microarray Core Henriette Remmer, PhD Protein Structure Core Thomas Saunders, PhD Transgenic Animal Model Core C Salyer, Office Manager J Krachie, Admin Spec TBA Ext Billing TBA Admin Spec TBA Associate Director

13. Key Performance Indicators Internal recharge revenue External revenue Number of services rendered Number of laboratories served Research impact (number of grants or projects involved, number of publications using core data) Regularly review all-funds budgets to evaluate financial model and to identify financial trends

14. Benchmarked Data and Performance Many BRCF cores are nationally recognized Transgenic Animal Model Core – internationally recognized for expertise and quality (one of few to guarantee transgenic founders) DNA Sequencing Core – nationally recognized for expertise, size, quantity and quality of data obtained, price of services Biomedical Research Store – nationally recognized for size and efficiency of operation Flow Cytometry Core – nationally recognized for size and throughput