1. FIGURE 1 0 200 400 600 800 1000 -+-+-+-+Phentolamine Rest Exercice LFD HFD NS * # Extracellular glycerol release (µM)

2. 0,5 1 1,5 2 2,5 3 -10-9-8-7-6-5 0,5 1 1,5 2 2,5 3 -10-9-8-7-6-5 0,5 1 1,5 2 2,5 3 -10-9-8-7-6-5 Log [epinephrine] (M) * * * * Fold basal increased + RX 821002 Day 0 Day 2 + BrPal A B C FIGURE 2 Log [Iso] (M) -6 Log [Iso] (M) n = 9 -6

3. TABLE 1 Low Fat DietHigh Fat Diet Glycerol, µmol/l92 ± 13107 ± 14 NEFA, µmol/l360 ± 46618 ± 86 * Norepinephrine, pg/ml210 ± 13186 ± 11 Epinephrine, pg/ml25 ± 424 ± 3 Glucose, mmol/l4.5 ± 0.14.0 ± 0.1 * Insulin, µU/ml3.9 ± 0.22.9 ± 0.2 * -hydroxybutyrate, mmol/l 0.33 ± 0.14.8 ± 1.17 *

4. TABLE 2 RestExercice 60 min Glycerol, µmol/l LFD HFD 92 ± 13 107 ± 14 233 ± 36 * 412 ± 28 * Norepineprine, pg/ml LFD HFD 210 ± 13 186 ± 11 871 ± 87 * 964 ± 107 * Epinephrine, pg/ml LFD HFD 25 ± 4 24 ± 3 94 ± 11 * 119 ± 25 *

5. TABLE 3 ARNm 2 -AR / Cyclophilin LFD HFD 0.36 ± 0.11 0.44 ± 0.10 NS

6. TABLE 4 Bmax (fmol/mg protein) Kd (nmol/l) Day 0559 ± 451.50 ± 0.5 Day 2 532 ± 1591.27 ± 0.5 Day 2 + BrPal 630 ± 1281.26 ± 0.5

7. TABLE 5 Day 0Day 2 Cont BrPal High affinity sites IC50 (nmol/l) 7.89 ± 0.058.46 ± 0.04 59.9 ± 0.10 ** Low affinity sites IC50 (nmol/l) 2.04 ± 0.151.55 ± 0.114.13 ± 0.26 *