1. Testicular Anatomy

2. Sertoli cell nucleus

3. Gonadal Differentiation cortical medullary

4. Mullerian and Wolffian Duct Systems cervix

5. External Genitalia

6. Brain Differentiation testis testosterone TETE BRAIN What does testosterone do developmentally? Tonic secretion of GnRH in puberty

7. Summary Undifferentiated gonad Y-chromosome: SRY  TDF Embryonic Testis Sertoli cells Leydig cells MIFMullerian duct regression testosterone Wollfian duct DHT Masculinization of external genitalia estrogen Masculinization of the brain