1. 1 ABOUT USObjectives, Innovation, Team, Our partners, carrier TECHNOLOGYPublications, Answer to your questions MARKETS PRODUCTS ACHIEVEMENTS R&D(ne pas mettre de détails dans le menu déroulant pour pouvoir changer) NEWS CONTACTSHow to join imXPAD, Register Menu déroulant

2. 2 Tumor simulated by a Na22 radioactive source introduced inside the mouse HOME ____________ ImXPAD is a company which build and sell the XPAD hybrid pixel detectors The XPAD detector is based on the hybrid pixel technology providing an impressive noise reduction, as well as a very high dynamic range and a fast frame rate. These qualities are fundamental for X-ray imaging, in particular for the synchrotron beam light domain where the state of art detectors cannot benefit of the progress brought by the second generation machines. For the bio-medical imaging like CT scanners the CdTe XPAD detectors allows for dose reduction as well as contrast improvement due to energy selection. Moreover, with some more R&D the XPAD will open the possibility of color-CT which, in addition to the anatomic imaging by X-ray absorption, provides information on the atomic composition of the crossed objects. This is a revolution in the CT scanner since it provide s more information than the more expensive IRM imaging. CdTe XPAD detector HOME Welcome to imXPAD ABOUT US TECHNOLOGY MARKETS PRODUCTS ACHIEVEMENTS R&D NEWS CONTACTS XPAD at the SOLEIL Synchrotron (Grenoble, france) PHOTO Changée

3. 3 The Company imXPAD is the acronym for “Imaging with the XPAD detector”. The XPAD detector (X-ray Pixel detector with Adaptable Dynamic range) is a hybrid pixel detector developed at the Centre de Physique des Particules de Marseille (CPPM-IN2P3/CNRS). The company is created to industrializing and commercializing XPAD detectors of different sizes and dimensions. The first detectors will be of small and medium sizes, with the intent to increasing their dimension in a short time scale. For an efficient start, the company will benefit from the collaboration of experts and equipments from CPPM. imXPAD is committed to be listen to its customers for the service after sales as well as for detector adaptation to their special needs

4. 4 Company / Objectives At start, the target market is the research on material sciences (synchrotrons and laboratories), either directly or via OEM. The market will then be soon extended to small animal imaging. Later on, other domains such as dental imaging, clinical angiography, clinical imaging, material survey and homeland security will be exploited. In addition, imXPAD collaborate with CPPM experts for R&D, in particular by developing large CdTe detectors to set up and demonstrate color CT imaging, a new way of imaging X-rays that will bring CT into the world of molecular imaging. CdTe high energy detectors will then be optimized in size and performances to enter the market of dental applications. MOUSE Changé

5. 5 Company / Innovation As an example the following characteristics of the XPAD cannot be obtained with the detectors currently in use like CCDs and CMOS pixels:  Noise suppression  Energy selection  Almost infinite dynamic range  High Detector Quantum Efficiency (DQE) (~100%, dose reduction)  Ultra fast electronic shutter (10 ns)  Frame rate ~ 1 kHz The significant advantages of the XPAD, in particular the high dynamic range and the high frame rate draw the interest of the professionals in material sciences (crystallography), who are working with laboratory sources as well as with high luminosity synchrotron beam light. The high quantum efficiency and the energy selection is prominent for biomedical imaging applications since this allows for dose reduction and multi contrast agent imaging (color CT). The XPAD detectors benefit from the hybrid pixel technology, which leads to major advantages with regards to the present detectors in use. These advantages are mainly provided by direct photon conversion and real time electronics analysis of the X-ray photons, allowing for direct photon counting. Moreover, the sensor material can be adapted to the energy range of the impinging X-ray driven by the application. Mounting the XPAD OK

6. 6 What makes the XPAD hybrid pixel detector better than CCDs & CMOS Company / Innovation A COMPLETER

7. 7 imXPAD management team Bernard DINKESPILER, President of imXPAD, is an electronics engineer who has worked for more than 25 years at CNRS-IN2P3, in the field of high energy physics experiments. After leading the department of electronics of CPPM (20 people), he joined the hybrid pixels development group in 2005. He is the author of the patents on the readout architecture of the XPAD3 chip. He spent a few years at SMU (Southern Methodist University, Dallas-Texas, USA) as a senior research associate. Dr Pierre DELPIERRE, General manager of imXPAD, he is a scientist very well known in the international instrumentation community. He was at the origin of the hybrid pixel technology together with E. Heijne at CERN (Geneva, Switzerland). He was the project leader of the pixel detectors of the DELPHI (world premiere) and ATLAS experiments at CERN from which imXPAD valorize the developments. The company will benefit of his scientific and technical experience, in particular for the research and development program. He was awarded the “prix cristal CNRS” in 1997 and the “Grand prix de l’académie des sciences” in 1999. Christian MOREL, Scientific advisor, is a physics engineer. He is Prof. at the Dept of Physics of the Aix-Marseille University and chairs the imXgam – X and gamma ray imaging group at CPPM. He will share his experience in the field of biomedical imaging by attending the Administration Council of the society. He is co- author of a patent that describes the use of photon counting for color CT. He was laureate of the ANR Programme « Chaires d’excellence » in 2005 and received the Rotblat Medal in 2009. He has been elected member of the IEEE NMISC from 2005 to 2008 and is member of the the French GDR MI2B (Modelling and Instrumentation for Bio-Medical Imaging) council since 2008. Company / Team

8. 8 imXPAD management: Dinkespiler : Bernard President Delpierre : PierreGeneral manager Morel ChristianScientific advisor imXPAD operation and R&D Technical service (3 persons) Commercial service (1 person)

9. 9 Company / Our Partners Centre de Physique des Particules de Marseille, our main collaborator for the XPADs fabrication knowhow and R&D http://mawww.in2p3.fr Université de la Méditerrannée, scientific collabration in physics and biology http://www.univmed.fr The CPPM group of biomedical imaging, our main collaborator for R&D (CT scanner and PET/CT) http://imxgam.in2p3.fr/links.php Neel Institut/ESRF, France, has participated to the XPAD prototyping and continue to help us for test in synchrotron beam http://www.neel.cnrs.fr SOLEIL synchrotron (Saint-Aubain, France) detector group, has participated to the XPAD prototyping and continue to help us for test in synchrotron beam http://www.synchrotron-soleil.fr Institut de Biologie du Développement de Marseille-Luminy, collaborate on R&D for CT and PET/CT tests on diseased mice http://www.ibdm.univ-mrs.fr OK

10. 10 Company / Carriers Currently the imXPAD company has no hiring project OK

11. 11 HYBRID PIXEL DETECTOR TECHNOLOGY The XPAD detectors are built in the hybrid pixel technology developed for high energy physics experiments. The idea is to provide a complete electronics analysis chain for each pixel in such a way that each pixel is able to suppress the noise by using a threshold set in energy, and then to count and to store the selected photons on its own. This electronics is embedded in a dedicated integrated circuit connected pixel by pixel on a pixilated X-ray sensor. As shown on the side picture, the photons are directly converted in the semi- conductor sensor, resulting in the creation of electric charges that are read by the micro-electronics circuit. Technology Unlike the CCD’s the XPAD detectors proceed by direct detection and do not need a scintillator nor optical fibers. Moreover, they count photons one by one, instead of integrating an X-ray light flux. These two properties provide a much sharper PSF function and no blooming effect. OK

12. 12 Technology/Publications Since 20 years the founders of imXPAD have been working on hybrid pixel detectors. First for high energy physics experiments (P. Delpierre has more than 200 publications) then for the application on X-ray imaging. Here are the most significant and recent publications: S. Nicol et al., Design and construction of the ClearPET/XPAD small animal PET/CT scanner, Proceedings of the IEEE-MIC 2009 conference, to be published in TNS 2010; F.Debarbieux et al.,Repeated Imaging of Lung Cancer Development Using PIXSCAN, a Low Dose Micro-CT Scanner Based on XPAD Hybrid Pixel Detectors, TNS Feb. 2010, vol.57, No.1. J.F. Berar et al., XPAD3 hybridpixel detector applications, Nucl. Instr. Meth. A607 (2009) 233–235 P. Pangaud et al., " XPAD3-S: A fast hybrid pixel readout chip for X-ray synchrotron facilities", Nucl. Instr. and Meth. A 591 (2008) 159-162. S. Basolo et al., "A 20 kpixels CdTe photon-counting imager using XPAD chip", Nucl. Instr. and Meth. A 589 (2008) 268-274. P. Delpierre et al., "XPAD: A photons counting pixel detector for material sciences and small-animal imaging", Nucl. Instr. and Meth. A 572 (2007) 250-253. P. Pangaud et al., "XPAD3 : a new photon counting chip for X-ray CT-scanner", S. Valton et al., "Evaluation of tomographic reconstruction methods for small animal microCT and microPET/CT", Nucl. Instr. and Meth. A 571 (2007) 278-281. OK

13. 13 Technology/Publications (suite, même page) P. Delpierre et al., “PIXSCAN: Pixel Detector CT-Scanner for small animal imaging,” in Conf. Rec. of the IEEE Med. Imag. Conf., San Juan, Puerto Rico, Oct. 2005. Nucl. Instr. Meth. A 571 (2007) 425–428. S. Basolo et al. Pixel detector for material Sciences. Proc of IEEE-NSS 2004, Rome. TNS Oct. 2005, Vol. 52 5, p1994-1998 J.F. Bérar et al., "A hybrid pixel detector for x-ray diffraction diffusion", Nucl. Instr. and Meth. A 510 (2003) 41-44. P. Delpierre et al., "Large surface X-Ray Pixel detector", IEEE Trans. Nucl. Sci. 49 (2002) 1709-1711. J.F. Bérar et al., "A pixel detector with large dynamic range for high photon counting rates", Journal of Applied Crystallography 35 (2002) 471-476. P. Delpierre, J.F. Bérar, L. Blanquart, B.Caillot, J.C. Clemens, C. Mouget, X-Ray Pixel Detector for Crystallography, NSS-MIC/IEEE, Lyon, 15-20 Oct. 2000, IEEE Trans. of Nuclear Sciences, Vo.48, No.4, Aug.2001, 987-991. P. Delpierre, Protein crystallography at the SLS. Proceeding of the pixel détector workshop,Villigen, Switzerland, 9-10 November 1998. P. Delpierre. Pixel detectors and silicon X-rays detectors. Frontiers in sciences and technology with synchrotron radiation, Journal de Physique III, vol. 4, nov. 1994 P. Delpierre and J.J.Jaeger. A sparse data scan circuit for pixel detector chips, Nucl. Inst. Meth. A305 (1991) 627 OK

14. 14 Technology/Often asked questions Why should I choose an hybrid pixel detector and not a CCD or CMOS detector? Renvoi au tableau de comparaison XPAD vs CCD dans “innovation” Can the system be controlled by a standard PC Yes, directly for the small detectors, Yes for the large detector but via an embarked PC+ Express card (included in the detector package) Will you adapt the control and readout software to our machine control system? Yes, as an example it is already adapted to the TANGO system for ESRF and SOLEIL Is the detector heavier than a standard CCD detector? No, the weigh is about the same

15. 15 Accueil La société Technologie Marchés Produits Réalisations R & d Actualité Contacts MARKETS FUTURE MARKETS CRYSTALLOGRAPHY PRECLINICAL IMAGING

16. 16 Markets/ Crytallography All the X-ray experiments and measurements will benefit from the XPAD innovative characteristics (quasi-infinite dynamic range, very fast frame rate, etc..) and new domains will be open like: -Selection of bunches corresponding to laser or electrical crystal stimulation using the fast electronic shutter (< 100 ns) - Observation on 3D of change on small peaks associated with defects which are located near major crystal peaks. These changes are not visible using CCD’s or CMOS detectors, they are commonly done with crossed slits and scintillation counters scanning each point and wasting a big amount of time (a factor more than 50) The X-ray imaging for fundamental and applied research, concern mainly the dedicated synchrotrons and the specialized public and private laboratories. The energy range (7-25 keV) allows the use of silicon sensors with a good detection efficiency. The sales will be done either directly (to the detector services, beam line responsibles, laboratory scientists) or via the firms which built machines like crystallographers. There are about 25 synchrotrons in Europe and more than 50 in the word. Each synchrotron has more than 20 beam lines. The XPAD installed on the goniometer of the D2AM/CRG beam line at the ESRF synchrotron (Grenoble, France) Image changée Légende changée Ajouter ce texte:

17. 17 Markets/biomedical imaging The other innovative characteristics of the XPAD like noise suppression and fast frame rate will be very attractive for pre-clinical imaging. To begin with, we target the mouse CT imaging with medium size silicon sensors and local color radiography and non destructive diagnostic with small CdTe sensors. Simultaneously we make R&D together with the CPPM to produce large surface CdTe detectors. This will allow the market to be extended to bigger animals (rat,..) and even the veterinary and clinical domain. The sales will be done to the firms building radiographic planes and micro-CT for small animal imaging and non destructive diagnostics. The XPAD detector provides energy thresholds which open a new imaging facility called COLOUR SCANNER. The standard CT-scanner gives an image based on the absorption of the X-Ray photons by the organs and bones. The brightness given by each pixel depends of the absorption power of the material found along the photon path. This is done with a polychromatic X-Ray source then there is a lose of contrast because the absorption power depends of the photon wave length. With the XPAD one can select an energy window by threshold setting on different pixels and recover the maximum contrast. Moreover one can use the K-edge effect to identify the material (or contrast agent) traversed by the photon and assign it a specific color and provide real color CT images. Pixscan II, the new CT-scanner built with the XPAD3 at the CPPM by the imXgam team. XPAD OK

18. 18 Markets/Future markets XX Accurate time window X XXXX Frame rate = 1 kHz XX X X On the fly readout XXNo readout dead time X XXXXXXXXLarge dynamic range X XXX XX Dose reduction XX XEnergy selection XXXXXXXXNoise suppression Crystallography Laboratories Crystallography Synchrotron Preclinical Scanner Clinical Angiography Clinical Scanner Waste Sorting Homeland security FUNCTIONS APPLICATIONS All X-ray imaging domains will benefit from the XPAD technology, thus opening a number of markets for the imXPAD company. Any imaging process will find more than one advantages in the specification list of the XPAD detector. As an example this table gives what function will be of the best interest for a given application. Pas net, tableau à refaire Voir tableau EXCEL

19. 19 Products/summary For an efficient start imXPAD produce medium size silicon and small CdTe pixel detectors. In less than two years the size of the detectors will increase, following the progress of the R&D and the demand from our customers. The available products are:  Small and simple silicon hybrid pixel detectors 70 or 130 kpixels (75 x 15 mm2 or 75 x 30 mm2) Until 500 images can be stored in a local memory at 2 ms per image. Then they can be readout to the PC at 10 Hz. Medium size silicon hybrid pixel detectors 350 or 500 kpixels (75 x 75 mm2 or 75 x 120 mm2) The images are stored directly in the PC with an ultra fast frame rate (500 Hz) provided by optical fiber links to a PCI-express interface. Small CdTe hybrid pixel detector 40 kpixels (20 x 30 mm2) Until 500 images can be stored in a local memory at 2 ms per image. Then they can be readout to the PC at 10 Hz. OK

20. 20 Products/ XPAD 70 or 130 kpixels Silicon detector The XPAD 70 or 130 kpixels does not need any interface nor power supply. All is included, just plug on any PC and play. It is delivered ready to use with a user friendly software package. Technical specifications Performances Dynamic range32 bits: 1/ 4 x 10 9 Counting rate per pixel5 x 10 5 X-rays/s (3 x 10 7 X -rays/sec/mm 2 ) Energy range7 - 40 keV Quantum efficiency9 keV: 99%, 15 keV: 70% (measured) Energy resolution1 keV Adjustable threshold range 6-30 kV Threshold dispersion150 eV Readout time2 ms Framing rate10 Hz Point-spread function1 pixel CoolingAir-cooling Power consumption10 or 14 W Dimensions Pixel size130 x 130 µm2 Pixels number560 x 120 = 67200 pixels or560 x 240 = 134 400 pixels Area75 x 15 mm2or 75 x 30 mm2 Sensor thickness500 µm Number of modules1 (no inactive gap) Overall dimensions (WHD)100 x 110 x 180 mm Weight 3 kg Application: Material sciences X-ray diffraction (XRD) Surface diffraction (SD) Small-angle scattering (SAXS) Powder diffraction Economic and easy to use silicon pixel detector 500 images can be stored in a local memory in less than 2 ms per image (allowing for time resolved experiments). Prendre ce titre, applcations et particularités Et non celles du CdTe

21. 21 Products/ XPAD 340 kpixels, 7,5 x 7,5 cm2 Silicon detector or 500 kpixels, 7,5 x 12 cm2 Silicon detector Technical specifications Dynamic range32 bits: 1/ 4 x 10 9 Counting rate per pixel5 x 10 5 X-rays/s (3 x 10 7 X -rays/sec/mm 2 ) Energy range7 - 40 keV Quantum efficiency9 keV: 99%, 15 keV: 70% (measured) Energy resolution1 keV Adjustable threshold range4-30 kV Threshold dispersion150 eV Readout time1 ms Framing rate500 Hz Point-spread function1 pixel CoolingAir-cooling Power consumption30 or 45 W Dimensions Pixel size130 x 130 µm2 Pixels number560 x 600 = 336 000 pixels or560 x 960 = 537 600 pixels Area75 x 75 mm2 or 75 x 120 mm2 Sensor thickness500 µm Number of modules5 or 8 Gapsx=0, y=4pixels, 1,6% of total area partially inefficient orx=0, y=4pixels, 2,9% of total area partially inefficient Overall dimensions (WHD) 180 x 180 x 250 mm3 Weight 5 kg Application: Material sciences X-ray diffraction (XRD) Surface diffraction (SD) Small-angle scattering (SAXS) Time-resolved experiments Powder diffraction and Small animal imaging The XPAD 340 or 500 kpixels is delivered ready to use with: - the complete readout system (interfaces, optical fibers and dedicated PC), - the user friendly software package, - dedicated training. In the standard version the modules are tiled (inclined by 7°) which saves significantly the dead area but it can also be assembled flat on request. Fast medium size silicon pixel detector The images are stored directly in the PC with an ultra fast frame rate (500 Hz) provided by optical fiber links to a PCI-express interface. OK

22. 22 Products/ XPAD 40 kpixels CdTe detector The XPAD CdTe40 kpixels does not need any interface nor power supply. All is included, just plug on any PC and play. It is delivered ready to use with a user friendly software package. Economic and easy to use CdTe pixel detector 500 images can be stored in a local memory in less than 2 ms per image (allowing for time resolved experiments) Application: Material sciences X-ray diffraction (XRD) Surface diffraction (SD) Small-angle scattering (SAXS) Powder diffraction And Small animal color radiography Non destructive diagnostic Technical specifications Performances Dynamic range32 bits: 1/ 4 x 10 9 Counting rate per pixel5 x 10 5 X-rays/s (3 x 10 7 X -rays/sec/mm 2 ) Energy range8 - 70 keV Quantum efficiency Energy resolution600 eV Adjustable threshold range 8-70 kV Threshold dispersion180 eV Readout time2 ms Framing rate10 Hz Point-spread function1 pixel CoolingAir-cooling Power consumption10 W Dimensions Pixel size130 x 130 µm2 Pixels number160 x 240 = 38 400 pixels Area20 x 30 mm2 Sensor thickness700 µm Number of modules1 (no gap) Overall dimensions (WHD)144 x 110 x 180 mm Weight 3 kg OK

23. 23 Achievements/Summary Since 20 years the CPPM pixel group develops hybrid pixel detectors, at the beginning for high energy physics experiment and then for X-ray imaging. Number of prototypes have been produced and tested on beam for material sciences and biomedical imaging. XPAD2 XPAD in Biomedical imaging XPAD in the SOLEIL synchrotron beam XPAD for tumor localization and evolution study XPAD versus CCD’s on a synchrotron experiments First XPAD fabrications The origin of the XPAD technology Image changée Mettre les images et renvoisdans cet ordre

24. 24 Since 1990, hybrid pixel detectors are being developed at the (CPPM) for micro vertex trackers in high energy physics experiments. In 1996 the first hybrid pixel detector (in the world) was installed in the heart of the DELPHI (LEP, CERN, Geneva) experiment, under the direction of P. Delpierre, project leader. Recently a vertex detector (2 m 2 of Si hybrid pixels) has been installed in the heart of the ATLAS experiment on the Large Hadron Collider (LHC, CERN, Geneva). From the performance of the DELPHI pixel detector, it became obvious that the photon counting technology can also be applied to X-ray imaging and bring significant improvement. In 1998, the CPPM Pixel group started to develop a dedicated pixilated micro-electronics circuit for X-ray imaging. One year later the XPAD1 detector was born. DELPHI (LEP experiment) Pixel vertex detector, 1996 ATLAS (LHC experiment Pixel vertex detector, 2008 Achievements/ The origin of the XPAD technology OK

25. 25 Achievements/ First XPAD fabrications After some improvements, the XPAD2 circuit was produced and a large area (6,5 x 6 cm2) detector was built, at that time the largest in the word. This detector was widely tested at the ESRF/CRG- D2AM beam line in Grenoble, and then at the new synchrotron SOLEIL near Saclay. To assess the added value of pixel detectors for biomedical imaging, a micro-CT scanner named PIXSCAN was developed at the CPPM with the XPAD2 detector and studies on mouse therapeutic models are thoroughly carried on with it. Later on a new micro-CT scanner has been built with the XPAD3 detector (7,5 x 12 cm2) and a more sophisticated image reconstruction software. For industrial development, a last version of the XPAD3 detector, was developed in collaboration with the Neel/ESRF laboratory and the detector group of the synchrotron SOLEIL. Several large size (7.5 x 12 cm 2 ) detectors have been built and the associated software was developed. These detectors have been largely tested on synchrotron beams as well as on the PIXSCAN CT-scanner and some of the results are described here. The technology is now ready for industrial fabrication. XPAD hybrid pixel detector OK

26. 26 Achievements / XPAD versus CCD’s on a synchrotron experiments Diffusion by a quasi-crystal of AlPdMn (NEEL laboratory-ESRF/CRG, Grenoble, France). The large high dynamic range of the XPAD allows to observe simultaneously the high intensity Bragg peak and the diffuse structures showing the intrinsic “disorder” characteristic of the quasi crystal. Moreover, the data obtained with the XPAD photon counting detector have a true Poisson statistics (σ =26 for photons), which help for the physical interpretation. XPAD3 image Integrated: data, red XPAD3, black CCD Mettre en relief en gras et RAL OK

27. 27 RECIPROCAL SPACE TOMOGRAPHY (SOLEIL/DiffAbs, Saint Aubin, France)‏ High resolution X-ray diffraction experiments on highly distorted semiconductor layers have strong experimental requirements: measuring the weak scattering from defects as well as the main diffraction peaks which might be more intense by 6 orders of magnitude. Aim : to characterize distortions in a GaInAs layer epitaxialy grown on a GaAs single crystal surface : these strains modify the electronic properties. They also enlarge the small peaks associated with defects which are located near major crystal peaks, here (111). This kind of experiments can not be performed with CCD’s, they are commonly done with crossed slits and scintillation counters scanning each point and wasting a big amount of time. Achievements /XPAD in the SOLEIL synchrotron beam Image by courtesy of Marc Gailhanou (CNRS/IM2NP, Marseille) OK

28. 28 Achievement / XPAD in Biomedical imaging Guecko Mouse With the XPAD detector, improvements in medical imaging are expected:  Large DQE due to optimum efficiency by the use of high density sensor material aiming to dose reduction  high speed data acquisition and high frame rate  Improved contrast because the XPAD detector is noiseless and allows for the subtraction of image taken at energies before and after absorption steps of contrast agents. To test these properties two CT-scanners have been built at CPPM, a first one with the XPAD2 detector and the second one with the XPAD3 detector. Tomography and image reconstructions have been performed at CPPM. The contrast in soft tissues is indisputable. OK

29. 29 Achievement /XPAD for tumor localization and evolution study Dose reduction Because of the large DQE of the XPAD, very low dose CT-scans are possible. As an example, with 10 mGy only (more than 20 times less than the usual dose for small animal CT) a lung tumor is still visible (yellow arrow). This allows for repeated examinations of the same mouse without any damage. Monitoring tumor mass expansion from repeated imaging sessions every 3-4 days from the second week post injection (D14 to D24). Maximum section of the tumor has been underlined (yellow) and its area was plotted versus time (F.Debardieu, IBDML, France). Tumor surface evolution Day post injection Maximal tumor area OK

30. 30 R&D/Summary Currently our main R&D projects are:  Large size CdTe detectors The aim in the development of large size CdTe detector is to improve the efficiency at high energy and to allow 60 keV X-rays to be used in biomedical imaging and on high energy synchrotron beam.  A participation to a prototype of Color CT scanner developed at the CPPM The XPAD will open the possibility of color-CT which, in addition to the anatomic imaging by X-ray absorption, provides information on the atomic composition of the crossed objects. This is a revolution in the CT scanner since it provides more information than the more expensive IRM imaging.

31. 31 3 x 2 cm2 CdTe XPAD detector illuminated by an americium 241 radioactive source. R&D / Medium size CdTe Detectors Small size (2 x 3 cm 2 ) have been designed and very well working, both at low and high energy, as it can be seen on this picture However, now the day it is impossible to find large size CdTe sensors and lots of R&D around the word are going on to increase the CdTe lingo size, regarding the high interest of this material for clinical imaging. The CPPM is working in collaboration on large size CdTe pixel detectors with in collaboration with the European HIZPAD (ELISA) project (http://hizpad.esrf.eu).http://hizpad.esrf.eu The plan of imXPAD is to develop a 6 x 6 cm2 CdTe detector in a time scale of one year. That will open the bio-medical market with dose reduction and the high energy synchrotron beam line customers. The challenge is to use our standard modules but equipped with CdTe sensors instead of silicon. The problems will be to find strong bump-bonding and good quality sensors as large as possible. Texte changé

32. 32 R&D / Color CT scanner The idea is the benefit from the energy selection capability of the XPAD and separate different organs by looking at the K-edge of different contrast agents. This R&D is underway at the CPPM (Centre de Physique des Particules de Marseille). Already different tests have been done to explore the feasibility of color CT. For example, images of a rubber tube filled with a iodine solution have been done before and after the K-edge of iodine and the subtraction of the two images give the iodine solution only (see the figure). Our participation will be a new electronic chip (the XPAD4) more convenient for this application. In particular it will include a double input polarity (for Si as well as CdTe) and a double threshold (to select one energy window in one picture). This imXPAD chip will also provide an improvement for all other X-ray imaging applications and in particular for protein Crystallography. Left: Image of a rubber tube filled with a iodine solution Right: Result of the subtraction of image before and after the K- edge energy of the iodine. Only the iodine solution is visible on this image.

33. 33 News/summary CPPM news Conferences announcements

34. 34 News from the CPPM: XPAD for cancer research Tumor simulated by a Na22 radioactive source introduced inside the mouse Simultaneous TEP/CT image done with the ClearPET/XPAD. Kidneys and lungs are segmented and appear grey. The left image shows only the CT data, the right image shows fused CT and PET data. The imXgam group at CPPM has succeeded a simultaneous PET/CT scan of a mouse. Positron Emission Tomography (PET) allows for imaging tumors, while X-ray CT scans give images of the anatomy. Fusion of PET and CT images are used to localize the position of the tumors with respect to the anatomy. Sate-of-the art PET/CT scanners do not allow to acquire PET and CT data at the same time. If the patient of the animal moves between the two examinations (even by breathing) the fusion of the images might not be precise. Simultaneous PET/CT scans are true co-registration of both modalities. Ultimately, CT images can be used to correct for respiratory or cardiac movements OK

35. 35 News / Conferences announcements  12th International Workshop on Radiation Imaging Detectors http://iworid2010.mrc-lmb.cam.ac.uk/  2010 IEEE Nuclear Science Symposium and Medical Imaging Conference and 17th International Workshop on Room Temperature Semiconductor Detectors www.nss-mic.org/2010  5th EUROPEAN MOLECULAR IMAGING MEETING – EMIM 2010 http://www.esmi2010.eu/  2010 World Molecular Imaging Congress http://www.wmicmeeting.org/dev/

36. 36 For any questions, technical or commercial: Delpierre Pierre delpierre@cppm.in2p3.frdelpierre@cppm.in2p3.fr Dinkespiler Bernard dinkespiler@cppm.in2p3.frdinkespiler@cppm.in2p3.fr CONTACTS Par Route Depuis l'est : Autoroute A50 et A8 Depuis l'ouest : Autoroute du Littoral Depuis l'est : Autoroute A7 http://www.asf.fr/. Transports en commun RTM (Régie des Transports Marseillais) Informations au 04 91 10 55 55 http://www.rtm.fr - Ligne 21 du Rond-Point du Prado direction "Luminy" - Ligne 24 de Dromel direction "Luminy" Address: Pépinière du Grand Luminy Zone Luminy Entreprises, CASE 922 13288 MARSEILLE Cedex 09 F. + 33 4 91 82 72 99 T. + 33 4 91 82 76 29 Par Air Aéroport : 04 42 14 21 14 http://www.marseille.aeroport.fr A 45 minutes de Luminy par l’Autoroute du Littoral Par train Gare Saint Charles Information réservations et billets à domicile : 08 36 35 35 35 http://www.sncf.fr A 30 minutes de Luminy (voiture ou transport en commun) Access: imXPAD CPPM parenthése Changé

37. 37 Register: OK Contact/customers Enlever la news letter