1. 1 MT vs CT: 28 day survival 10779969378958811223 10469398678268011223 Number at risk CT MT 868 779 0 25 50 75 100 051015202528 day % Surviving Monotherapy (MT) Combination Therapy (CT) Log-rank p-value: 0.0002 Kumar et al, Crit Care Med 2009 (in press)

2. 2 MT vs CT: 28 day pressor liberation MT CT 1223319108472116 122330090431812 15 12 Number at risk Pressor dependence (%) 0 20 40 60 80 100 Time (days) 051015202528 Log rank p-value = 0.03 Monotherapy (MT) Combination Therapy (CT) Kumar et al, Crit Care Med 2010;38:1773–85

3. 3 Combination vs Monotherapy: Primary Antibiotic Kumar et al, Crit Care Med 2010;38:1773–85

4. 4 Combination vs Monotherapy: Organisms Kumar et al, Crit Care Med 2010;38:1773–85

5. 5 Combination vs Monotherapy: Secondary Antibiotic Kumar et al, Crit Care Med 2010;38:1773–85

6. 6 Combination vs Monotherapy: Clinical Syndrome Kumar et al, Crit Care Med 2010;38:1773–85