1. Upfront Combination Therapy vs Step-Up Approach for PAH:

3. Program Themes

4. Case 1

5. Case 1: Background and Diagnostics

6. Case 1: Assessment

7. Monotherapy vs Initial Combination Therapy?

8. AMBITION Trial

9. Patient-Centered Approach

10. Clinical Follow-Up of Patients With PAH

11. GRIPHON: Treatment Effect by Subgroup

13. Case 2: Background

14. Case 2: Diagnostics

15. Case 2: Assessment

16. Monotherapy vs Initial Combination Therapy?

17. Initial Triple Therapy

18. PACES Trial Time to Clinical Worsening

20. Case 3: Background and Diagnostics

21. Case 3: Assessment

22. AMBITION Trial Results

23. Hospitalization in PAH Prognostic Significance

24. Concluding Remarks

25. Abbreviations

26. Abbreviations (cont)

27. Abbreviations (cont)

28. Abbreviations (cont)