1. Welcome to Chem 336 Lab Lecture Organic Chemistry Laboratory II Margareta Séquin

2. Dr. Margareta Séquin Office: Science 106C; Office Hours: Tu 11-12 pm, Th 1-2 pm and by appt. e-mail: msequin @ sfsu.edu Phone: 415-405-0315

3. http://userwww.sfsu.edu/~msequin

5. Chem 336 Prerequisite: passing grade (C or better) in Chem 333, 334; Chem 335 (can be taken concurrently). Prerequisites will be strictly applied. A student who withdraws from Chem 335 must also withdraw from Chem 336. Text: “Chem 334, 336, and 338 Organic Chemistry Laboratory”, SFSU 2005, with Mayo, Pike, Trumper, "Microscale Organic Laboratory", 4th Ed.; Wiley Custom Ed.

6. Grading MiniQuizzes at the end of lab lectures, 2 pts. each One Midterm Exam (100 points) on Tuesday, Oct. 14, 2008, 14:10, in your respective lab session. Final Exam (150 pts.) on Tuesday, Dec. 9, 14:10, comprehensive, with special emphasis on qualitative organic analysis. PLEASE NOTE: An exam not taken earns the grade F. Standard lab reports: 20 points/ lab report. Lab reports V and VI will be combined and will be 30 pts. Unknown reports will be 30 pts. each. PLEASE NOTE: Late reports incur point deductions. Lab Notebooks will be checked regularly. Your total class grade will be calculated as follows: 40% Exams % (Midterm plus Final Exam plus Mini Quizzes %) 30% Lab reports % 30% Lab preparation, notebook, attendance, participation.

7. http://userwww.sfsu.edu/~msequin

9. Exp.1: Solvolysis of tert Butyl Chloride 1.What is the IUPAC name for tert butyl chloride, for the alcohol product? 2.Write the mechanism. 3.Write the rate equation. 4.Why does changing the solvent medium affect the rate? 60%water:40%acetone; 70%water:30%acetone; 80%water:20%acetone What practical reasons do chemists have for measuring reaction rates?

10. 1.Measuring the tenth–life in our reaction 2.What is a possible by-product of our reaction? Does this affect our data? 3.How would the following affect the reaction rate: A one-third decrease of concentration of RX? A 20 o C increase in temperature? A 20 o C decrease?

11. Calculations for Exp.1: Solvolysis of tert Butyl Chloride p.354-355

12. Calculations for Exp.1: Solvolysis 1. 2. 3. 4.

13. Calculations for Exp.1: Solvolysis at t 10%, [RCl] = 0.90 [RCl] o =kt 10% -ln 0.90[RCl] o [RCl] o -ln =kt 10% 0.90= 0.1053 0.1053 t 10% =k Units of k? How could you calculate k by using the half life?

14. Arrhenius Equation and Calculation of Ea and A What does E a tell us about the reaction? ln k = ln A -E a /RT Plot ln k vs. 1/T for each solvent mixture ln k 1/T y = b + m x R=1.987216 cal/K mol

16. Next time: Kinetics (conclusion) Friedel-Crafts (Exp.2)