1. Hemophilia Anthony Triplin Steve Jean Jude Saint-Jean February 1, 2010 Period:3

2. Hemophilia Blood does not clot as quickly Most common in males Also known as Christmas disease Double vision, repeated vomiting, extreme fatigue Only males get type A and B Females get type C Type C less common

3. Location of Hemophilia Located on X chromosome

4. Mode of Inheritance Hemophilia is sex linked/ x-linked Can only be passed down on X chromosome Hemophilia A ( 1 in 10,000 male births, 1 in 100,000,000 female births)

5. Alleles Two alleles for each gene Half from your mom and half from your dad A capital letter for dominant allele and a lower-case letter for the recessive allele Dominant allele takes over a recessive allele Recessive produces only when its paired allele is identical The dominant chromosome is represented as X H The recessive chromosome is represented as X h

6. Hemophilia Punnett Squares XHXH Y XHXH XhXh XHXHXHXH XHYXHY XHXhXHXh XhYXhY Punnett squares are used to show the probability of receiving a genetic disorder from a parent. YXhXh XHXH XHXH XHXhXHXh XHYXHY XHXhXHXh XHYXHY XhXh Y XHXH XhXh XHXhXHXh XHYXHY XhXhXhXh XhYXhY Male w/ hemophilia and female non-carrierMale w/ hemophilia and female carrierNormal Male and female carrier

7. Punnett Square Probability Ratios: 2: 2 X H X h 2 X H Y Percentages: 50%: 50% X H X h 50% X H Y YXhXh XHXH XHXH XHXhXHXh XHYXHY XHXhXHXh XHYXHY Male w/ hemophilia and female non-carrier

8. Punnett Squares Genotypes and Phenotypes What do the letters mean ? Uppercase letters represent dominant genes Lowercase letters represent recessive genes H is the dominant allele h is are the recessive allele Phenotype/What We See H = Normal Hh = Hemophilia Carrier YXhXh XHXH XHXH XHXhXHXh XHYXHY XHXhXHXh XHYXHY Genotype/What Is In Our Genes H is the Homozygous dominant Hh is the heterozygous dominant Male w/ hemophilia and female non-carrier