1. Advanced Course on Bioinformatics and Comparative Genome Analysis Fredj Tekaia Institut Pasteur tekaia@pasteur.fr Introduction

2. Advanced Course on Bioinformatics and Comparative Genome Analysis June 30 - July 12, 2008 Universidade Federal de Santa Catarina, Florianopolis, Brazil Organizers/Contact: Course web page: http://www.pasteur.fr/~tekaia/ACBCGA.html Alberto M.R. Davila, Instituto Oswaldo Cruz, FIOCRUZ, Rio, Brazil; Edmundo Grisard, Universidade Federal de Santa Catarina, Florianopolis, Brazil; Hugo Naya, Institut Pasteur Montevideo, Uruguay; Fredj Tekaia, Institut Pasteur Paris, France.

3. Financial support CNPq/QUADTRYP/FINEP

4. Why this course ?

5. 672 53 94 http://www.genomesonline.org/ Tree of life Complete genomes 3823 projects 819 published (12-06-08) 1848 Bacteria 90 Archaea 936 eukaryotes 130 metagenomes 3 phylogenetic domains; Lifestyles: mesophiles; (hyper)thermophiles; psychrophiles; extreme conditions,...

6. Number of available completely sequenced genomes GOLD List and references List and references Completely sequenced Genomes that span the three domains of life are growing at a rapid rate 06-2008 3823 projects

7. Genome studies show that: Access to entire genome sequences is revolutionizing our understanding of how genetic information is stored and organized in DNA, and how it has evolved over time. The sequence of a genome provides significant details of the gene catalogue within a species. Comparisons of complete genome sequences show the acceleration in the understanding of species organisation, links between genes, functions of the genes, evolution of genes, genomes and species. => Beyond fundamental biological and methodological interests, Expected applications include: Drug, Medical and Agricultural,… discoveries.

8. Few scientists are involved in generating data and much more are involved in data analyses

9. Genomics Is the study of genomes. (including the study of their genes, proteins, their sequences, functions, evolution,....)

10. Bioinformatics is needed to transform the flood of raw data (sequences) into scientific knowledge.

11. MathematicsStatistics Nucleotide & protein sequences and related informations Informatics Biology Bioinformatics

12. Information system: http://www.ncbi.nlm.nih.gov Bibliography

13. Bibliography: http://www.ncbi.nlm.nih.gov/PubMed http://www.plosbiology.org

14. The main objectives of the course are to familiarize you with bioinformatics and large scale genome data analyses skills by introducing: 1- advanced fundamental algorithms in Bioinformatics; 2- their application in genome analyses; 3- recent knowledge acquired from genomes studies and their perspectives. Bioinformatics and Comparative Genome Analysis

17. We hope that this course will motivate some of you to continue their involvement in these fascinating domains: Bioinformatics and Genomics.

18. Enjoy this exiting program and your stay in Florianopolis.