1. An Agent-Based Model of Recurring Epidemics in a Population with Quarantine Capabilities Brendan Greenley Period 3

2. Why An Epidemic Model? Epidemics have been responsible for great losses of life and have acted as a population control (Black Plague, Spanish Influenza) Epidemics are still a cause of concern today and in the future (SARS, H1N1 Swine Flu) Analyzing certain characteristics of an epidemic outbreak or response can help shape plans in case of a real outbreak. http://www.solarnavigator.net/animal_kingdom/animal_i mages/death_black_plague_street_scene.jpg

3. Why Agent-Based? Originally tried System Dynamics Agent-Based Modeling makes more sense –Individual behaviors differ and can greatly affect the course of an epidemic outbreak –A user can observe an individual agent over time –Children can inherit values from two parents –Continuous visual representation of population

4. Scope of project Population/environment bounds dictated by computer resources All about seeing how epidemics balance a hypothetical population where disease outbreaks are the only constraint. Quarantine option allows for analysis on how a population’s response to a epidemic helps/hinders its overall carrying capacity Aging, mating, and survival behaviors all seen in model

5. NetLogo NetLogo 4.0.4 (Developed at Northwestern) Programming environment/language allows for System Dynamics & Agent Based Modeling Cross-platform support –Windows, *Nix, Mac Depends on Java Free!

6. Setup User Control Panel 2D World On-the-fly Plotting

7. User Control Panel (UCP)

8. UCP Details mating-freq – The minimum amount of ticks an agent must wait between mating. virus-mutation-rate – The number of ticks before the base-susceptibility of all agents is reassigned along a bell curve, a pocket of infections emerges. And quarantine efforts are reset from the quarantine area. max-ticks-alive – The maximum amount of ticks an agent may live to. This is then plugged into an equation which determines the probability of an agent from dying from non- epidemic causes as a function of age. Important in limiting population spikes during spans of time free of epidemics max-days-sick – An infected agent is hosts the epidemic for this amount of time. If an agent survives to this point, there is a 30% chance of him/her recovering and gaining immunity.

9. Unbounded 2D World

10. 2D World Breakdown: Immune Agents Susceptibility value low enough that agent is safe from infection Can only die from age, or by losing immunity due to a new virus mutation or by having susceptibility increase due to age. Agents who survive an epidemic outbreak are immune until it mutates

11. 2D World Breakdown: Susceptible Agents Susceptible agents are able to get sick, magnitude of susceptibility represented by shading (white to olive, somewhat susceptible to very susceptible) Susceptibility values determined by age and a randomly distributed “base-susceptibility” value. (Use 9th polynomial representation of 1918 Influenza W-shaped susceptibility curve to adjust base-susceptibility with age.

12. Susceptibility Adjustment

13. 2D World Breakdown: Infected Agents Moves more slowly than healthy agents Can spread disease to neighbors Leaves a red path behind Forced to stay in quarantine zone if escorted there. Gain immunity if they survive, though more likely to die.

14. 2D World Breakdown: Quarantine Officers Number dictated by QuarantineMagnitude variable slider Never mate or die from age Take shortest path back to 3x3 quarantine zone once they have someone to escort. Officer position and number are reset and recalculated every time the virus mutates.

15. Quarantine Zone

16. Procedures General Agent: –Move in random direction, avoid escorted infected persons, quarantine zone –Check for potential mate –Check for exposure to epidemic –Check to see if natural death is going to occur –Age++ Quarantine Agent: –Move in a random direction –Check for infected persons in a two patch radius, if any exist, force them to follow you –Take any infected persons escorting towards quarantine zone –If no infected agents being escorted, continue patrol spiddlement.wordpress.com

17. BehaviorSpace Allows user to export data to spreadsheets and tables Can incrementally increase specified variables as the model runs Useful for post-run data analysis in Excel

18. Results Severe, recurring epidemics can successfully limit a populations growth over the long term. Quarantines can help raise the carrying capacity by 13%, and by even more with large magnitude quarantine responses.

20. Results (continued) Increasing quarantine magnitude also increases the long-term mean population. Type of relationship difficult to decipherer, appears to differ based on virus duration, world size, and initial-immunity variables.

23. In Conclusion In a population where population restraints such as food, shelter, and personal safety are met, epidemics can act as a population constraint. The implementation of a quarantine can increase the long-term carrying capacity of such a population, increasing the magnitude of the quarantine results in further increase in carrying capacity.

24. Timeline First Quarter –Used System Dynamics Modeling Second Quarter –Late Dec: Switched to Agent-Based Modeling, formed basic procedures and agent types –Jan: Implemented susceptibility distribution Implemented more realistic mating/children characteristics Learned how to use BehaviorSpace

25. Timeline (Continued) February –Implemented aging procedures –Have infected agents movement limited March –Implemented quarantine zone –Added quarantine agents –Implemented quarantine officer patrolling –Implemented smarter susceptible agents (they avoid quarantine zones and officers on their way to the zone with infected persons in tow) April/May –Made age a factor of susceptibility –Recalculated quarantine response every mutation –Data collection, making conclusions –Analyze runs with and without quarantine, and with differing magnitudes of quarantines responses and conclude effects on carrying capacity.

26. Project Evolution System Dynamics -> Agent Based Short-term -> Long-term Predetermined equations -> complex system affected by hundreds of individual decisions

27. Future Extensions Create version where world is bounded. Give users a factor representing selfishness/selflessness, where infected agents take it upon themselves to seek quarantine or instead seek to avoid quarantine officers. Give quarantine agents specified paths to sweep Introduce multiple quarantine areas.

28. Thank You.