1. neuGRID PROJECT: A PRACTICAL EXAMPLE OF RESEARCH THROUGH THE GARR

2. THE CONSORTIUM Vrije Universiteit Medical Centre, THE NETHERLANDS Frederik Barkhof CF consulting s.r.l., ITALY Carla Finocchiaro Carla Finocchiaro National Alzheimer’s Centre Fatebenefratelli, Brescia, ITALY GB Frisoni, Coordinator Karolinska institutet, SWEDEN Lars-Olof Wahlund University of the West of England, Bristol, UK Richard McClatchey, Technical Supervisor Prodema GmbH, SWITZERLAND Christian Spenger, Alex Zijdenbos Maat Gknowledge SL, SPAIN David Manset HealthGrid, FRANCE Yannick Legré, Tony Solomonides

3. OBJECTIVE COMPUTATIONAL CENTRE

4. TOMORROW neuGRID

5. neuGRID’s OBJECTIVE To develop a grid-based environment for the collection/archiving of large amounts of imaging data paired with computationally intensive data analysis tools (testbed cortical thickness extraction)

6. ACTION PLAN Phase 3 Foundation M12 Phase 2 Phase 1 Deployment M24 Completion M36

7. ... Data Archiving & Computing Site – DACS Data Collection Site – DCS neuGRID Infrastructure A Layered Infrastructure Grid Coordination Centre - GCC Data Coordination Centre - DCC Virtual Database Ground Truth Infrastructure Ground Truth (Grid and Data Coordination Centers – Core Services) Physical Resources Physical Resources (Data Storage + Compute Power) Physical Resources Physical Resources (Data Storage + Compute Power) End-Users End-Users (Accessing infrastructure through web portal) and CoreLabs (Data Acquisition)

8. DEPLOYED neuGRID Infrastructure A Layered Infrastructure DEPLOYED Expected infrastructure of 500 Cores 30TB 500 Cores and 30TB of storage fully dedicated to neuGRID Local clusters Local clusters available in case at KI and VUmc Expected infrastructure of 500 Cores 30TB 500 Cores and 30TB of storage fully dedicated to neuGRID Local clusters Local clusters available in case at KI and VUmc

9. LoNI PipelineKEPLER NeuroSciences Algorithms / Pipelines NeuroSciences Algorithms / Pipelines Gridification Model Initial Prototype – Today (2)

10. MammoGrid LORIS LORISMammoGridCombination of LORIS & MammoGrid technological glueGrid as the technological glue DeploymentDeployment of the Solution in relevant major centres accross Europe neuGRID Technology neuGRID

11. Business Logic (Specific Services) Business Logic (Specific Services) Domain Logic (Generic Services)‏ Domain Logic (Generic Services)‏ Backends Middleware (Underlying IT legacy assets, e.g. EGEE gLite, mySQL, Globus, Oracle 11g...) Backends Middleware (Underlying IT legacy assets, e.g. EGEE gLite, mySQL, Globus, Oracle 11g...) 11 Security (All services concerned with authentication, Authorization within the platform) Security (All services concerned with authentication, Authorization within the platform) Monitoring, Logging and Accounting (Provides the mechanisms to store, archive and sort all log information. The layer is concerned with services which allow efficient monitoring of all infrastructure resources) Monitoring, Logging and Accounting (Provides the mechanisms to store, archive and sort all log information. The layer is concerned with services which allow efficient monitoring of all infrastructure resources) Workflow Management (SOA Governance is in charge of defining, accessing, executing, operating and maintaining reusable services with appropriate quality of services and conforming With all other requirements, e.g. Security, privacy...) Workflow Management (SOA Governance is in charge of defining, accessing, executing, operating and maintaining reusable services with appropriate quality of services and conforming With all other requirements, e.g. Security, privacy...) Backends Abstraction (Software abstraction from databases, grid, enactment environments...) Backends Abstraction (Software abstraction from databases, grid, enactment environments...) neuGRID Architecture Service-Oriented Architecture Web Portal Generic to ALL domains (can theoretically be fully reused) Generic to Medical domain (can theoretically be reused in other medical applications) Specific to Project (can theoretically be partly reused in similar projects since abstracted from underlying IT) Common Purpose Interfaces Highly Specialized Interfaces

12. Initial Prototype – Today (1) Web Portal AJAX-based Portal CAS SSO Framework Grid Proxy Applet MyProxy Session Web Portal AJAX-based Portal CAS SSO Framework Grid Proxy Applet MyProxy Session LORIS Database Connected to SSO Interfaces to Data Acq to Data QC Interfaces to Data QC LORIS Database Connected to SSO Interfaces to Data Acq to Data QC Interfaces to Data QC Online Shell Access GSISSH Applet Access to Grid Infra. CIVET Pipeline gridified SFTP Facility to Upload Online Shell Access GSISSH Applet Access to Grid Infra. CIVET Pipeline gridified SFTP Facility to Upload LINK to the neuGRID PORTAL

13. CBRAIN - Canadian Brain Imaging Research NetworkCBRAIN - Canadian Brain Imaging Research Network –Recently funded by CANARIE (Canadian Advanced Network and Research for Industry and Education) UCLA LoNI – Pipeline EnvironmentUCLA LoNI – Pipeline Environment NeuroLOGNeuroLOG –Funded by the French ANR Related Initiatives A Worldwide Neuroscience Network? Potential infrastructure of 6000 Cores 200TB 6000 Cores for 200TB of storage Offering advanced capabilities State-of-the-art and main Data Mining and Statistical Toolkits As well as a wide range of generic medical services Potential infrastructure of 6000 Cores 200TB 6000 Cores for 200TB of storage Offering advanced capabilities State-of-the-art and main Data Mining and Statistical Toolkits As well as a wide range of generic medical services