1. Introduction to meta-analysis in Review Manager (RevMan).
Ewelina Rogozinska
CT Data Assistant/Researcher
Women's Health Research Unit

2. The systematic review process
Formulate research question
Design search strategy
Search bibliographic databases
Further selection of primary studies using inclusion criteria
Identify possible papers from titles/abstracts
Retrieve papers
Quality appraisal
Extract data
Synthesis
Formulate research /
policy conclusions

3. Session overview Brief introduction What do we use RevMan for?
Setting up RevMan file
Practical part
Adding studies
Add outcome
Data entry
Conducting meta-analysis
Add new comparison
Introducing subgroups
Generating plots and graphs
Introduction to meta-analysis in RevMan
Ewelina Rogozinska

4. Working with RevMan
Review Manager (RevMan) - software used for preparing and maintaining Cochrane Reviews.
You can use RevMan for protocols and full reviews.
It is most useful when you have formulated the question for the review and allows you to:
prepare the text,
build the tables showing the characteristics of studies and the comparisons in the review,
add study data,
perform meta-analyses and
present the results graphically.
It can be downloaded from Cochrane web page

5. Tasks Add two new studies: Mardones 2007 and Zhou 2012
Add new outcome ‘Birth weight (g)’ under comparison ‘Fish oils’ and specify:
Type of data: continuous
Analysis model: random
Effect measure: mean difference
Analysis details: totals and subtotals
Graph details
To outcome ‘Birth weight (g)’ add studies: Mardones 2007 and Zhou 2012
Transfer earlier extracted data for birth weight from these two studies
Introduction to meta-analysis in RevMan
Ewelina Rogozinska

6. Tasks Create new comparison ‘Diet and fish oils’ and specify:
Type of data: dichotomous
Stat method: Mantel-Haenszel
Analysis model: random
Effect measure: Risk Ratio
Analysis details: totals and subtotals
Graph details: scale 10.0
Add studies and create two subgroups:
First: diet
Second: fish oils
For outcome ‘Pre-eclampsia (PET)’ generate:
Forest plot;
Funnel plot
Risk of bias graph
Introduction to meta-analysis in RevMan
Ewelina Rogozinska