1. Knowledge Transfer @CERN
Manjit Dosanjh Knowledge Transfer
SKF, Rabat, 11 May 2013

2. Knowledge Sharing
CERN considers knowledge and technology transfer as an integral part of its mission.
CERN technologies have applications in several domains with high relevance to society.
Showing tangible benefits to society from key application domains important to illustrate the impact and role of fundamental research as a driver for innovation.
CERN as an education and training centre
CERN as a catalyser for collaboration

3. The tools of the trade ……….
Detectors
Accelerators
Computing
Brain behind the web

4. Accelerator Technologies
Base Technologies: LHC
Superconductivity
(12kA)
Cryogenics (1.9 K)
Vacuum
(10-13 atm)
Magnets
(8 T)

5. Detector Technologies
Challenge: sample the results of up to 600
million proton-proton collisions per second!
LHC detectors have sophisticated electronic trigger systems that precisely measure the passage time of a particle to accuracies in the region of a few billionths of a second. The trigger system also registers the location of the particles to millionths of a metre. This is essential for ensuring that the particle recorded in successive layers of a detector is one and the same.

6. Medipix
A family of single photon counting integrated circuits used in Hybrid Silicon Pixel Detectors
The Medipix collaborations helps with development and dissemination of the technology
A good example of how (fundamental) science fosters innovation which can be transferred to society… and back!

7. Langton Ultimate Cosmic ray Intensity Detector uses 5 Timepix chips to monitor the radiation environment in Space
allows students to use a Timepix chip in the lab to visualise radiation
Data from LUCID and detectors will be uploaded to the Grid and made available for students to analyse

8. From high vacuum…
NEG (Non-Evaporable Getter thin film coatings)
Technology used to create and maintain ultra-high vacuum in the accelerator vacuum chambers.

9. … to solar energy!
License and partnership with a start-up company
Development of a commercial product able to use diffused or indirect light and reach very high temperatures of up to 300 degrees
Development of a prototype production chain

10. Solar panels plant
Civil-engineering company opened a new solar power plant
Environmentally friendly "solar field" heats close to 80,000 cubic metres of bitumen to 180 degrees.

11. KT Fund: Funding Innovation
The KT Fund is a small financial catalyst which tries to bridge the gap between CERN and society
Requests from researchers are evaluated for impact
A cheap/sensitive radon detector……
Teaching tools ……
Open Hardware license
First Touch-Screen
First mouse

12. CERN Technologies and innovation
Combining accelerators, detectors and IT to fight cancer
Detecting
particles
Accelerating particle beams
Large-scale computing (Grid)
CANCER
First Bern Cyclotron Symposium - June 5-6, 2011
Manjit Dosanjh 12

13. Cancer is a large and growing challenge Need: Earlier diagnosis, better control, fewer side-effects
How?
new technologies
Imaging, dosimetry, accelerator & detector technology
Better understanding – genetics, radiobiology…
Advanced healthcare informatics …
international collaboration
If progress is to be maintained
Although cancer is a common condition, each tumour is individual
Need personalised approach
Large patients data to understand the key drivers of the disease

14. Catalysing collaboration in health field
Challenges:
Bring together physicists, biologists, medical physicists, doctors
Cross-cultural at European and global level
Why is CERN/HEP well placed to do this?
It is widely acknowledged as a provider of technologies and as a catalyst for collaboration.
It is international, non-commercial, not a health facility.
ULICE Kick-off in 2009
ENVISION approval in 2009
Enlight meeting leading to subm. Of ENTERVISION
PARTNER: 21 researchers recruited last year.

15. Conventional Radiotherapy in 21st Century
3 "Cs" of Radiation
Cure (~ 45% cancer cases are cured)
Conservative (non-invasive, few side effects)
Cheap (~ 5% of total cost of cancer on radiation)
(J.P.Gérard)
There is no substitute for RT in the near future
The rate of patients treated with RT is increasing
Present Limitation of RT:
~30% of patients treatment fails locally
(Acta Oncol, Suppl:6-7, 1996) 15

16. One photon beam 80 30 50

17. Two opposite photon beams
110
100

18. Hadrontherapy: all started in 1946
In 1946 Robert Wilson:
Protons can be used clinically
Accelerators are available
Maximum radiation dose can be placed into the tumour
Proton therapy provides sparing of normal tissues
Depth in the body (mm)
Conventional: X-Rays Ion Radiation 18

19. Proton & Ion Beam Therapy: a short history
Proposed by R.R. Wilson
MedAustron (Austria)
1st patient at Berkeley by Lawrence
CNAO, Pavia (Italy)
1st patient in Europe at Uppsala
HIT (carbon), Heidelberg (Germany)
1984
1989
1990
1991
1992
1993
1994
2002
1946
1954
1957
2009
2011
2014
PIMMS
PSI, Switzerland
Eye tumours, Clatterbridge, UK
ENLIGHT
ENLIGHT
10th year
GSI carbon ion pilot, Germany
CPO (Orsay), CAI (Nice), France
Loma Linda (clinical setting) USA
Boston (commercial centre) USA
NIRS, Chiba (carbon ion) Japan

20. Hadron Therapy is Radiation Therapy
PATIENT
All Multi disciplinary
Diagnosis
Imaging
Planning
Treatment
Follow-up
Mazal 2012
 integration & synergy between clinics & R&D

21. 10 years of ENLIGHT Collaboration CERN philosophy into health field
Common multidisciplinary platform
Identify challenges
Share knowledge
Share best practices
Harmonise data
Provide training, education
Innovate to improve
Lobbying for funding
Coordinated by CERN
> 150 institutes
> 400 people
> 25 countries
(with >80% of MS involved) 21

22. A Biomedical Facility @ CERN
The LEIR facility could be adapted to be used for :
basic physics studies
radiobiology
fragmentation of ion beam
dosimetry
test of instrumentation
A meeting at CERN in 2012, attended by
more that 200 people from >20 countries
discussing the need for such a facility
More information in the latest issue of “ENLIGHT HIGHLIGHTS”
LEIR

23. Preparing for the Future
Objective
Review progress in physics for health
Identify areas for development
Explore synergies
physics and health
Catalyse dialogue
doctors, physicists, medical physicists……
Result:
First workshop on Physics for Health
@CERN in Feb 2010

24. Next ICTR-PHE Conference
International Conference on Translational Research in Radio-Oncology & Physics for Health in Europe
February 27 – March 2, 2012 at CICG, Geneva
2 days devoted to physics, 2 days to medicine, 1 day of overlapping topics
Over 700 people registered, nearly 400 Abstracts
Chairs: Jacques Bernier (Genolier) and Manjit Dosanjh (CERN)
Next ICTR-PHE Conference
10-14 February 2014
Four physics subjects :
Radiobiology in therapy and space
Detectors and medical imaging
Radioisotopes in diagnostics and therapy
Novel technologies

25. Useful links http://cern.ch/ULICE http://cern.ch/ENLIGHT
ENLIGHT/ULICE annual meeting July 2013, MedAustron
Register to join ENLIGHT:
confId=180036
LEIR Biomedical facility meeting:
ICTR-PHE

26. Thank you for your attention manjit.dosanjh@cern.ch

27. CERN Open Hardware Licence
A legal framework to facilitate knowledge exchange across the electronic design community.
In the spirit of knowledge and technology dissemination, the CERN OHL was created to govern the use, copying, modification and distribution of hardware design documentation, and the manufacture and distribution of products.