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Invertebrate psychophysics allows detailed characterization of learning and memory, sensory acuity and perception Neural and behavioral plasticity

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Olfactory learning can be used to assay acuity: Generalization of CR to odors of increasing difference Conditioning odor Odor dimension (carbon chain length) Generalization gradient | Similar odors || Different odorsDifferent odors | Response probability

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.60.50.40.30.20.10 0 123456 Conditioning Trials Response probability 2-hexanone 1-hexanol 1-decanol Acquisition of CR to the conditioning odor N=80/group

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1-Hexanol 1-Heptanol 2-Heptanone 1-Octanol 2-Octanone 1-Decanol 2-Hexanone Cyclohexanone.80.70.60.50.40.30.20.10 0 Response probability 1-Hexanol 1-Heptanol 2-Heptanone 1-Octanol 2-Octanone 1-Decanol 2-Decanone Cyclohexanone Response probability.80.70.60.50.40.30.20.10 0 2-Hexanone 1-Heptanol 2-Heptanone 1-Octanol 2-Octanone 1-Decanol 2-Decanone Cyclohexanone Response probability.80.70.60.50.40.30.20.10 0 CS ketone alcohol cyclohexanone Generalization of the CR to conditioning and test odors N=80/group

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Inhibitory gradient Summation of + and – gradients along a single odor dimension Summed inhibitory and excitatory gradients Excitatory generalization gradient Theoretical odor dimension

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.60.50.40.30.20.10 0 12 34 56 Conditioning Trials Response probability 1-octanol (A) 1-hexanol (B).80.70.60.50.40.30.20.10 0 1-Heptanol 1-Octanol 1-Decanol 1-Hexanol 1-nonanol Response probability (CS+) (CS-) Differential conditioning produces + and – gradients which overlap along a single dimension and summate in predictable ways.

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.60 50.40.30.20.10 0 12 34 56 Conditioning Trials A. Response probability 1-heptanol (+) 1-hexanol (-) 1-Heptanol 1-Octanol 1-Decanol 1-Hexanol.80.70.60.50.40.30.20.10 0 (+) (-) B. Response probability a b a a Differential conditioning produces + and – gradients which overlap along a single dimension and summate in predictable ways.

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Methods for measuring odor detection thresholds characterize sensitivity to odor.

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Methods for measuring antennal sensitivity to odor.

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Methods for measuring odor discrimination thresholds.

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Do local networks within the AL function to enhance olfactory acuity generally? Detection Generalization Discrimination

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Generalization Do local networks within the AL function to enhance olfactory acuity generally?

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Discrimination Do local networks within the AL function to enhance olfactory acuity generally?

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Detection Do local networks within the AL function to enhance olfactory acuity generally?

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