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Carl Wei He (presenter) Dr. Song Liu University of Manitoba

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1 Carl Wei He (presenter) Dr. Song Liu University of Manitoba
Narrow Sized Dual-functional Microcapsules: Contact Infection Control and Drug Delivery Carl Wei He (presenter) Dr. Song Liu University of Manitoba

2 Contents Background Antimicrobial polyurea microcapsules
Concepts of Microcapsules Applications (esp. in textiles) Antimicrobial polyurea microcapsules Objective: provide contact wound dressings; Design: Feature and reasoning of the method Details and characterizations Shell thickness Drug release Contact antimicrobial property Future research Lead through the contents

3 What is a polyurea microcapsule?

4 Advances in polyurea microcapsules
medicine engineering Traditional applications Artificial blood cells Targeted/Triggered release Multi- functional carrier Electronic ink Water treatment Self-healing resin Polyurea microcapsules (PUMC) Textiles Agricultures

5 Application in textiles
Cosmetic textiles Aromatherapy & Fragrance Textiles Thermochromic & Photochromic textiles Pest repellent textiles Thermo regulating textiles Flame retardant textiles

6 Objective: Antimicrobial microcapsules
Dual functions: On-contact antimicrobial property To provide an active shell surface Controlled drug release property To control the thickness of shell Application Chronic wound care dressing: infection control and nutrition supply

7 Requirement for the capusles
Morphology: controlled size and size distribution Shell: matrix property: Stiff enough to retain spherical shape Thick enough to provide mass regulation Shell: Surface property: Easily dispersed in water for application Contact-killing effect

8 Strategy of synthesis Interfactial crosslinking

9 IR labelling of isocyanate group

10 Strategy of synthesis functional surfactant
Modification by incorporating a multifunctional surfactant Reduce interface tension Provide antimicrobial functionality Covalently bound to the matrix Increase shell thickness QAs

11 post-modification

12 in-situ modification

13 Comparison of two methods model capsules
Model capsules: shell thickness Cross-section of fluorescein stained model capsules; left: post-modified model capsule; right: in-situ modified model capsule; (a)(d) freshly prepared model capsule; (b)(e)cracked model capsules after CTAC extraction; (c)(f) close-up of fluorescein stained shell

14 Quantification of QAs density of model capsules
Quantification of QAs density of model capsules. Error bar is generated from 3 batch-to-batch measurements. Control: PUMC model capsule; MCQ100: in-situ modified model capsule; MC+Q: post-modified model capsule;

15 Comparison of two methods microcapsules
Up: in-situ modified polyurea microcapsules (MCQ) Down: control polyurea microcapsules (PUMC). (a) MCQ dispersed in water; (b) dry MCQ; (c) PUMC dispersed in water; (d) dry PUMC

16 In-vitro dissolution test
7-day in-vitro cumulative drug release profile for MCQ-Cmr; insert: first 24hr release curve; (drug load = 3.33 wt%; efficiency = 31%)

17 Antimicrobial test diffusion
(a): MCQ, Qas modified capsule; (b): Control, Polyurea capsule without modification; (c): Blank, last batch of washing solution of MCQ sample. Bacteria load: 4.54 log10 cfu/cm2; Capsule density: 0.88 mg/cm2

18 Antimicrobial test static contact
MCQ Control Bacteria load: 1.54 log10 cfu /cm2 Density of microcapsules mg /cm2

19 Antimicrobial test static contact
MCQ Control Bacteria load: 3.54 log10 cfu /cm2 Density of microcapsules mg /cm2

20 Conclusion Isocyanate residue on polyurea microcapsules can be utilized for functionalization. On-contact antimicrobial can be achieved on polyurea microcapsules Sustained drug release of drug is achieved by thick shell microcapsules. Polyurea microcapsule of narrow size distribution can be synthesized

21 Future research nanocapsules
Ease of immobolization Larger surface for functionalization

22 Future research platform development
Platform for functionalzation Other functional surfactants could be developted

23 Future research size control

24 Acknowledgements Manitoba Health Research Council (MHRC) Operating and Establishment grants Dr. Paul H.T. Thorlakson Foundation Fund University of Manitoba Research Grant Program (URGP) Dr. Xiaochen Gu Dr. Lingdong Li Dr. Rick Holley Dr. Saqer Herzallah

25 Thank you !

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