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Carl Wei He (presenter) Dr. Song Liu University of Manitoba Carl Wei He (presenter) Dr. Song Liu University of Manitoba.

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Presentation on theme: "Carl Wei He (presenter) Dr. Song Liu University of Manitoba Carl Wei He (presenter) Dr. Song Liu University of Manitoba."— Presentation transcript:

1 Carl Wei He (presenter) Dr. Song Liu University of Manitoba Carl Wei He (presenter) Dr. Song Liu University of Manitoba

2  Background  Concepts of Microcapsules  Applications (esp. in textiles)  Antimicrobial polyurea microcapsules  Objective: provide contact wound dressings;  Design: Feature and reasoning of the method  Details and characterizations  Shell thickness  Drug release  Contact antimicrobial property  Future research

3 Polyurea

4 medicine engineering Traditional applications Polyurea microcapsules (PUMC) Electronic ink Water treatment Self-healing resin Textiles Agricultures Artificial blood cells Targeted/Triggered release Multi- functional carrier

5  Cosmetic textiles  Aromatherapy & Fragrance Textiles  Thermochromic & Photochromic textiles  Pest repellent textiles  Thermo regulating textiles  Flame retardant textiles

6 Dual functions:  On-contact antimicrobial property  To provide an active shell surface  Controlled drug release property  To control the thickness of shell Application  Chronic wound care dressing:  infection control and nutrition supply

7  Morphology:  controlled size and size distribution  Shell: matrix property:  Stiff enough to retain spherical shape  Thick enough to provide mass regulation  Shell: Surface property:  Easily dispersed in water for application  Contact-killing effect

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10  Modification by incorporating a multifunctional surfactant ▪ Reduce interface tension ▪ Provide antimicrobial functionality ▪ Covalently bound to the matrix ▪ Increase shell thickness QAs

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13 Cross-section of fluorescein stained model capsules; left: post-modified model capsule; right: in-situ modified model capsule; (a)(d) freshly prepared model capsule; (b)(e)cracked model capsules after CTAC extraction; (c)(f) close-up of fluorescein stained shell

14 Quantification of QAs density of model capsules. Error bar is generated from 3 batch-to-batch measurements. Control: PUMC model capsule; MCQ100: in-situ modified model capsule; MC+Q: post-modified model capsule;

15 Up: in-situ modified polyurea microcapsules (MCQ) Down: control polyurea microcapsules (PUMC). (a) MCQ dispersed in water; (b) dry MCQ; (c) PUMC dispersed in water; (d) dry PUMC

16 7-day in-vitro cumulative drug release profile for MCQ-Cmr; insert: first 24hr release curve; (drug load = 3.33 wt%; efficiency = 31%)

17 ( a): MCQ, Qas modified capsule; (b): Control, Polyurea capsule without modification; (c): Blank, last batch of washing solution of MCQ sample. Bacteria load: 4.54 log 10 cfu/cm 2 ; Capsule density: 0.88 mg/cm 2

18 0.22 0.44 0.66 0.88 Density of microcapsules mg /cm 2 MCQ Control Bacteria load: 1.54 log 10 cfu /cm 2

19 0.22 0.44 0.66 0.88 Density of microcapsules mg /cm 2 MCQ Control Bacteria load: 3.54 log 10 cfu /cm 2

20  Isocyanate residue on polyurea microcapsules can be utilized for functionalization.  On-contact antimicrobial can be achieved on polyurea microcapsules  Sustained drug release of drug is achieved by thick shell microcapsules.  Polyurea microcapsule of narrow size distribution can be synthesized

21  Ease of immobolization  Larger surface for functionalization

22  Platform for functionalzation  Other functional surfactants could be developted

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24 Manitoba Health Research Council (MHRC) Operating and Establishment grants Dr. Paul H.T. Thorlakson Foundation Fund University of Manitoba Research Grant Program (URGP) Dr. Xiaochen Gu Dr. Lingdong Li Dr. Rick Holley Dr. Saqer Herzallah

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