1. Crosswalk CDE’s NRelevant to: CENTERTRACK Core28 (1 double)1921 Basic AH665354 CoreBasic AH Sex - GenotypeEd. Level USA * Race USA *Ed. Level primary care giver USA Ethnicity USA *Military Deployment Med. History SnowedBlast Inj. Device type Ped. GCSBlast – Direction type Ped. GCS - eyeBlast – Category Ped. GCS – motor (2 x)Blast – Enclosed Space indicator Ped. GCS - verbalBiological Agent – exposure type Ped. GCS – Total scoreChemical Agent – exposure likelihood Body –Armor indicator Military combat helmet type Ped. GOSE date time Ped. GOSE score Non relevant CDE’s * Relevant to TRACK

2. Crosswalk CDE’s: Harmonization N RelevantPresentCompatible EU/USCENTERTRACKCENTERTRACK Core19/2118 (95%) 20 (95%) 17 (89%) 19 (90%) Basic AH53/5450 (94%) 52 (96%) 49 (92%) 50 (93%) CENTERTRACK CoreEmployed expandedEdu. Primary care giver Basic AHInj. Date reliabilityAbusive head trauma GCS ConfoundersER Discharge SDH mixed density Not present CENTERTRACK CoreICD External causeBirth Date Basic AHEducational level USAEducational level Primary care giver Non compatible

3. CENTER-TBI https://www.center-tbi.eu/ PRIORITIES Teambuilding Set-up observational study ‐ Protocol ‐ CRF ‐ Provider profiling ‐ Informed consent ‐ Database Living systematic reviews http://neurotrauma.evidencemap.or g

4. CENTER-TBI https://www.center-tbi.eu/ UNEXPECTED CHALLENGES Selection CRO – delays because of European tender Standardization of MR acquisition Outcome instruments ‐ Translations ‐ Interpretation / differences US – Europe ‐ License fees

5. CENTER-TBI https://www.center-tbi.eu/ InstrumentCDE typeRequired translationsLicence fees GOSECore 7 free BSIBasic 7 USD 24.700,00 RAVLTBasicfree (non propriatary) TMTBasic 8 free (non propriatary) WAIS-IVBasicUSD 15.669,00 SF12Suppl. USD 10.558,00 SF36Suppl. QolibriSuppl. 14 free Qolibri-OSSuppl. 14 free RivermeadSuppl. 10 free (non propriatary) GOATSuppl. 14 free CANTAB/ / € 106.200,00 JFK coma recovery scale -revised - supplemental

6. CENTER-TBI https://www.center-tbi.eu/ PLEASANT SURPRISES Team spirit and enthusiasm Global franchising of CENTER-TBI concept