1. Marc Cohen-Renée Larocque Global Health Research Initiative Afri-Can Forum, January 18, 2013-Entebbe, Uganda The Global Health Research Initiative - GHRI

2. AGENDA The Global Health Research Initiative (GHRI) GHRI programs Overview of the Canadian HIV Vaccine Initiative (CHVI) GHRI and CHVI – where is the link? Q&A

3. GHRI was founded in 2001. It is a partnership of three Canadian government agencies: Canadian Institutes of Health Research (CIHR) Canadian International Development Agency (CIDA) International Development Research Centre (IDRC) IDRC is the “host” agency GHRI GHRI ProgramsOverview of CHVIGHRI-CHVI?Q&A

4. GHRI grants support 3 complementary areas of action: research (a range of multi-disciplinary approaches, including action-research, participatory research, RCTs, etc.) strengthening research capacity (learning-by-doing) knowledge translation (teams with decision-makers ) GHRI GHRI ProgramsOverview of CHVIGHRI-CHVI?Q&A

5. GHRI: 2001-2016 Where we work GHRI GHRI ProgramsOverview of CHVIGHRI-CHVI?Q&A

6. GHRI Programs Africa Health System Initiative-RES $26.6M 2006-2012 Teasdale-Corti $16.7M 2009-2014 $1.055M 2008-2013 CIII-Haiti $5.9M 2008-2014 $4M EcoEID in SE Asia GHRI contribution 2010-2013 HIV/AIDS Prevention Trials Capacity Building GHRIGHRI Programs Overview of CHVIGHRI-CHVI?Q&A

7. Ecohealth Emerging Infectious Diseases Program in Southeast Asia 3 projects 7 countries 2010-2013 4M$ GHRI contribution Where we work GHRIGHRI Programs Overview of CHVIGHRI-CHVI?Q&A

8. African Health Systems Initiative – Support to African Research Partnerships 10 projects 7 countries 2008-2014 5.9M$ Where we work GHRIGHRI Programs Overview of CHVIGHRI-CHVI?Q&A

9. HIV/AIDS Prevention Trials Capacity Building Grants, phase II 9 projects 30 countries 2009-2014 16.7M$ Where we work GHRIGHRI Programs Overview of CHVIGHRI-CHVI?Q&A

10. GHRIGHRI Programs Overview of CHVIGHRI-CHVI?Q&A

11. HIV/AIDS Prevention Trials Capacity Building Grant Phase2 Program offered in partnership with the Canadian HIV Vaccine Initiative (CHVI) through a financial contribution from the Canadian International Development Agency (CIDA) and the International Development Research Centre (IDRC) GHRIGHRI Programs Overview of CHVIGHRI-CHVI?Q&A

12. The Canadian HIV Vaccine Initiative (CHVI) Government of Canada (CIDA, CIHR, HC, IC, PHAC) and Bill & Melinda Gates Foundation partnership Initiated in 2007 to help accelerate efforts to develop a safe, effective, affordable and globally accessible HIV vaccine GHRIGHRI ProgramsOverview of CHVI GHRI-CHVI?Q&A

13. CHVI o bjectives are: To advance the basic science of HIV vaccine in Canada, and low-and-middle-income countries To support the translation of basic sciences discoveries into clinical trials To address the enabling conditions (regulatory, community) To advance the development of related technologies To improve the efficacy and effectiveness of HIV Prevention of Mother-to-Child (PMTCT) services in low-and-middle- income countries GHRIGHRI ProgramsOverview of CHVI GHRI-CHVI?Q&A

14. CHVI Advance the basic sciences of HIV Translation of sciences discoveries in clinical trial CIHR grantsGHRI/CIDA grants CIHR PHAC CIDA IC HC ACO Bill and Melinda Gates Foundation Team Grant: HIV/AIDS Vaccine Discovery and Social Research 5 Projects GHRI HIV Prevention Trials Capacity Building Grants 9 Projects GHRIGHRI ProgramsOverview of CHVIGHRI-CHVI? Q&A

15. Newsletter: Third issue GHRIGHRI ProgramsOverview of CHVIGHRI-CHVI? Q&A

16. Booklet… available today! GHRIGHRI ProgramsOverview of CHVIGHRI-CHVI? Q&A

17. Thank you Overview of CHVIProgram OverviewCollaborationLessons Q&A

18. Questions? GHRIGHRI ProgramsOverview of CHVIGHRI-CHVI?Q&A

19. Program objectives Strengthen the capacity and leadership skills of African researchers and institutions to undertake prevention trials with special focus on innovations in HIV/AIDS prevention, particularly HIV vaccines Support collaboration and networking of African researchers and research users in HIV/AIDS prevention trials related research and policy development Advance the collaboration and networking of Canadian and African researchers and institutions in global HIV/AIDS prevention trials efforts Overview of CHVIProgram Overview CollaborationLessonsQ&A

20. Program Design Belongs to: CHVI objective to support the translation of basic science discoveries into clinical trials African-led research teams Grants: up to CA$1.8M over 4 years Comprehensive approach to strengthening research capacity: trial administration and management, ethics reviews processes, securing funding, engaging communities and policy-makers, publishing results Overview of CHVIProgram Overview CollaborationLessonsQ&A

21. Complementary grants Up to CA$50 000 to support scientific excellence in HIV prevention research and capacity building of young researchers through learning-by-doing KAVI O. Anzala, Nadia Musimbi Chanzu CANSSA S. Allen, T. Ndung’u, William Kilembe, Mammekwa Mokgoro CAPT D. Wilson, L. Balfour, P. Kaleebu, B. Cameron, Rusha Govender, George Miiro Nigeria A. Abimiku, G. Garber, K. Corace, Susan Yilme TanZamBo R. Musonda, M. Wainberg, Simani Gaseitsiwe, Balthazar Nyombi, Mike Chaponda Overview of CHVIProgram Overview CollaborationLessonsQ&A

22. Project teams build capacities in : Good Clinical Practice Laboratory techniques Social and Biomedical Sciences Regulatory processes Advocacy Project teams use different approaches Short and long term trainings Mentoring Learning by doing Project teams audiences include Researchers Decison-makers Communities and media Overview of CHVIProgram Overview CollaborationLessonsQ&A

23. CIHR Programmatic Grants to tackle health and health equity Yassi, Engelbrecht (Workplace South-Africa) “ This GHRI-funded project was likely an important factor in leveraging a 5-year research programmatic grant from CIHR (Health Equity program) for our collaborative team, and the partnerships forged during this GHRI initiative will be crucial in the operationalizing of this research program”. Yassi A., Engelbrecht M., First Annual Report, 2011 Alary, Zannou (BENIN) Overview of CHVIProgram OverviewCollaboration LessonsQ&A

24. Projects teams 1. The Kenya AIDS Vaccine Initiative (KAVI): A Centre of Excellence for HIV Vaccine/Prevention Trials in East Africa- KENYA 2. Canada-Africa Prevention Trials (CAPT) Network – Proposal to Build African Capacity for HIV/AIDS Prevention Trials- UGANDA, SOUTH AFRICA, KENYA 3. TanZamBo Capacity Building for HIV Prevention Research Network- BOTSWANA, TANZANIA, ZAMBIA Overview of CHVIProgram Overview CollaborationLessonsQ&A

25. Projects teams 4. ADAPT2 (African Development of AIDS Prevention Trials capacities, second phase)- SOUTH AFRICA, NAMIBIA, BOTSWANA, LESOTHO, MALAWI, MOZAMBIQUE, SWAZILAND, TANZANIA, ZAMBIA, ZIMBABWE 5. West African Platform for HIV Intervention Research (WAPHIR)- SENEGAL, THE GAMBIA, GUINEA BISSAU 6. The Canada – sub-Saharan Africa (CANSSA) HIV/AIDS network: Building capacity for prevention trials research and clinical care in Africa- SOUTH AFRICA Overview of CHVIProgram Overview CollaborationLessonsQ&A

26. Projects teams 7. Creating a common platform for HIV vaccine research and HIV care and treatment program- NIGERIA 8. Closed: Preparing for HIV prevention randomized control trials- BENIN 9. Closed: Building capacity for HIV prevention trials in the health care workplace- SOUTH AFRICA Overview of CHVIProgram Overview CollaborationLessonsQ&A

27. Canada-Africa Prevention Trials Network Assist in developing 8 African HIV prevention research centres Build sustainable leadership through training opportunities Provide internal communications and facilitation of collaborative research initiatives

28. Kenya AIDS Vaccine Initiative (KAVI) Establish a Centre of excellence for training health care professionals in East Africa on vaccine trials Enhance lab capacity and capacity of local REBs/institutional administrators to handle vaccine development Build vaccine literacy/ acceptance among local communities, policy makers and other stakeholders

29. African Development of AIDS Prevention Trials (ADAPT2) Increase capacity to conduct HIV prevention trials in SADC countries through short methods courses Apply multi-country RCT logistical framework; build capacity to train students in methodology Increase capacity of African decision-makers to use research

30. Canada-sub-Saharan Africa HIV/AIDS network (CANSSA) African HIV/AIDS network of excellence Knowledge translation and training in clinical, biomedical and sociological research Clinical and laboratory infrastructure and establishment of pilot projects

31. West African Platform for HIV Intervention Research (WAPHIR) Strengthen lab capacity through improved immunology/virology techniques, and a clinical trial support training program with a lab platform

32. Nigeria team Creation of internationally certified HIV clinical research site Ability to conduct HIV vaccine clinical trials at the highest standard and build supportive lab capacity Build capacity in: clinical, research ethics, regulation community mobilization, risk cohort development vaccine cohort development

33. TanZamBo Capacity Building for HIV Prevention Research Network (TanZamBo) Capacity building of researchers to conduct HIV/AIDS prevention trials and research, including vaccines Institutional capacity building, improving expertise and technology Support for MSc training in clinical research/biostatistics and postdocs who manage the projects with PIs

34. Benin – Preparing for HIV prevention randomized control trials- Closed Capacity building for Bénin PhD students in Québec Maintaining l'Unité de Recherche en Prévention du VIH (UREPIV), Université d'Abomey-Calavi, to support researchers and community workers Maintaining sex worker cohort in Cotonou

35. South Africa – Building capacity for HIV prevention trials in the health care workplace- Closed Certificate program to train health care workers in research design, implementation and evaluation of workplace-based interventions for HIV & TB prevention