Presentation on theme: " Naif Bawazeer. History This 40 yr old female, past medically free, para 2+0. patient cant speak or hear. She complain of headache especially in."— Presentation transcript:
History This 40 yr old female, past medically free, para 2+0. patient cant speak or hear. She complain of headache especially in the morning mainly frontal associated with blurred vision, amenorrhea and enlargement in hand and foot since 7 years. Past 6 month symptoms progressed out of proportion and associated with lower limb weakness. Otherwise unremarkable.
Physical Examination Conscious, alert, with dysmorphic features including: protruded jaw, macroglossia, big hands and feet. Otherwise unremarkable.
History and Physical In case of pituitary adenoma: Mass effect: headaches, cranial nerve palsy, visual field defects + Hormonal effect: GH: increase in soft tissue, CTS (60%) Prolactin: Amenorrhoea. TSH: Hyperthyroidism. ACTH: Cushing's syndrome Apoplexy: sudden deterioration.
History and Physical Other causes of acromegaly: according on underlying cause will give us the clinical picture. + Hormonal effect: GH: increase in soft tissue, CTS (60%)
Treatment After searching the literature through:
Treatment American Association of Clinical Endocrinologists Medical Guidelines for Clinical Practice for the Diagnosis and Treatment of Acromegaly-2011 Update http://aace.metapress.com/content/5h1427154k550851/?id=5H1427154K550851
Treatment The Journal of Clinical Endocrinology & Metabolism May 1, 2009 vol. 94 no. 5 1509-1517
Treatment Enclosed pituitary tumor: Primary trans-sphenoidal surgery
Treatment In case of unresectable pituitary tumour (with neural or vascular impingement/invasion): Medical therapy: somatostatin analogs dopamine agonists growth hormone-receptor antagonist (GHRA) Debulking surgery Radiotherapy
Treatment In case of non-pituitary adenoma etiology: Medical VS surgical for underlying pathology
References 1- Cook DM, Ezzat S, Katznelson L, et al (AACE Acromegaly Guidelines Task Force). AACE medical guidelines for clinical practice for the diagnosis And treatment of acromegaly [published corrections Appear in Endocr Pract. 2005;11:144 and Endocr Pract. 2008;14:802-803]. Endocr Pract. 2004;10:213-225. Javer, A., Marglani, O., Lee, A., Matishak, M., & Genoway, K. (2008). Image-guided endoscopic transsphenoidal removal of pituitary tumours. Journal Of Otolaryngology - Head & Neck Surgery = Le Journal D'oto-Rhino-Laryngologie Et De Chirurgie Cervico- Faciale, 37(4), 474-480. 2- Johnson N. New approaches to the development and use of treatment guidelines. Formulary. 1998;33:665-678. 3. Mechanick JI, Bergman DA, Braithwaite SS, Palumbo PJ (American Association of Clinical Endocrinologists Ad Hoc Task Force for Standardized Production of Clinical Practice Guidelines). American Association of Clinical Endocrinologists protocol for standardized production of clinical practice guidelines [published correction appears in Endocr Pract. 2008;14:802-803]. Endocr Pract. 2004;10:353-361. 4. Alexander L, Appleton D, Hall R, Ross WM, Wilkinson R. Epidemiology of acromegaly in the Newcastle region. Clin Endocrinol (Oxf). 1980;12:71-79. 5. Daly AF, Rixhon M, Adam C, Dempegioti A, Tichomirowa MA, Beckers A. High prevalence of pituitary adenomas: a cross-sectional study in the province of Liege, Belgium. J Clin Endocrinol Metab. 2006;91:47694775. 6. Avagnina P, Martini M, Terzolo M, et al. Assessment of functional liver mass and plasma flow in acromegaly before and after long-term treatment with octreotide. Metabolism. 1996;45:109-113.