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Role of Amino Acids Protein monomeric units Energy source Precursors of other biological molecules Protein monomeric units Energy source Precursors of other biological molecules
3 In Mammals Plants and bacteria can produce all of them
Amino acids are precursors 4
8 Biosynthesis of Amino Acids The nitrogen cycle
9 Biosynthesis of Amino Acids Nitrogen Fixation -> Microorganism
10 Major Ammonium ion carrier Ammonium Ion Is Assimilated into Amino Acids Through Glutamate and Glutamine
11 Biosynthesis of Amino Acids
12 Biosynthesis of Amino Acids in Bacteria and Plants Essential ones are in bold letters
13 Biosynthesis of Amino Acids in Bacteria and Plants
14 Biosynthesis of Amino Acids: Transaminations Amino Acid 1 + -Keto Acid 2 Amino Acid 2 + -Keto Acid 1 Glutamate + - Ketoglutarate + Pyridoxal phosphate (PLP)- Dependent Aminotransferase
Products of Amino Acid Breakdown Glucogenic – Pyruvate – -Ketoglutarate – Succinyl-CoA – Fumarate – Oxaloacetate Ketogenic – Acetyl-CoA – Acetoacetate
Animals cannot carryout net synthesis of precursors of gluconeogenesis from acetyl-CoA or acetoacetate
17 Amino Acid Metabolism
18 Fate of the C-Skeleton of Amino Acids
19 Fate of the C-Skeleton of Amino Acids
20 Fate of the C-Skeleton of Amino Acids Aromatic amino acids need oxygenases + O 2
21 Fate of Nitrogen in Different Organism
Overall Urea Cycle (Liver)
Carbamyl Phosphate Synthetase (CPS) CPSI (Mitochondria) – Uses NH 3 – Urea Cycle CPSII (Cytosol) – Uses Glutamine – Pyrimidine Biosynthesis
Carbamyl Phosphate Synthetase (CPS) Mechanism
Activation of HCO 3 – by ATP
Displacement of Phosphate by NH 3
Phosphorylation of Carbamate by ATP
Ornithine Transcarbamylase (OTC) (Mitochondrion)
Citrulline Carrier (Ornithine Antiport)
Argininosuccinate Synthetase (Cytosol)
33 Ammonium Ion is Converted into Urea Urea cycle
34 The Urea Cycle is Linked to the Citric Acid Cycle NH 4 +
1 Amino Acid Metabolism 1.Proteins are degraded to amino acids 2.Removal of nitrogen is first step in degradation 3.Ammonium is converted into urea 4.C-skeleton.
Nitrogen Cycle. Summary of Protein and Amino Acid Metabolism.
Digestion of Proteins 25.7 Degradation of Amino Acids 25.8 Urea Cycle Chapter 25 Metabolic Pathways for Lipids and Amino Acids.
Nitrogen Metabolism Pratt and Cornely Chapter 18.
FCH 532 Lecture 22 Chapter 26: Amino acid metabolism Quiz Monday on Transamination mechanism Quiz on Wed. for Urea Cycle.
Detoxification of ammonia and biosynthesis of urea. The basic features of nitrogen metabolism were elucidated initially in pigeons.
Amino acid metabolism · Nitrogen balance protein catabolism, synthesis biosynthesis normal N balance: N ingested = N excreted negative N balance: N ingested.
FCH 532 Lecture 20 Quiz on Wed. Amino acids (25 min) Quiz on Friday Citric Acid Cycle (25 min) Chapter 26: amino acid metabolism New HW posted.
Amino Acid Degradation and Nitrogen Metabolism Chapter 30, Stryer Short Course.
17.8 Amino Acid Catabolism Amino acids from degraded proteins or from diet can be used for the biosynthesis of new proteins During starvation proteins.
Chapter Twenty-Three The Metabolism of Nitrogen. Nitrogen Fixation Nitrogen fixation is the reduction of N 2 to NH 3: Bacteria are responsible for the.
Fig. 23-1, p.630 Amino acids act principally as the building blocks and to the synthesis of variety of other biologically molecules. When a.acids deaminated.
Chapter Twenty-Three The Metabolism of Nitrogen. Nitrogen Fixation Nitrogen fixation is the reduction of N 2 to NH 3 : Bacteria are responsible for the.
CHAPTER 20 PROTEIN METABOLISM. Nitrogen of Amino Acids nitrogens to be excreted are collected in glutamate which is oxidized to -ketoglutarate and NH.
Biochemistry 432/832 February 14 Chapter 26 Amino Acid Metabolism.
Chem 454: Biochemistry II University of Wisconsin-Eau Claire Chem 454: Biochemistry II University of Wisconsin-Eau Claire Protein Turnover and Amino Acid.
Metabolism of Amino Acid. Amino Acid Pool The amount of free amino acids distributed throughout the body is called amino acid pool Plasma level for most.
Biochemistry: A Short Course Second Edition Tymoczko Berg Stryer © 2013 W. H. Freeman and Company CHAPTER 30 Amino Acid Degradation and the Urea Cycle.
Principles of Biochemistry Fourth Edition Chapter 17 Amino Acid Metabolism Copyright © 2006 Pearson Prentice Hall, Inc. Horton Moran Scrimgeour Perry Rawn.
Chapter 23 The Metabolism of Nitrogen Mary K. Campbell Shawn O. Farrell Paul D. Adams University of Arkansas.
FCH 532 Lecture 21 Chapter 32: Translation Quiz today (Wed.) on amino acids Quiz on Friday TCA cycle Quiz on Monday Transamination mechanism.
Degradation of amino acids Amino acid breakdown can yield: –Acetyl-CoA – -KG –Succinyl-CoA –OAA –fumarate.
18.2 Nitrogen Excretion and the Urea Cycle Produced in liver Blood Kidney urine.
Amino acids - Classifications, Amino acids Physico – Chemical Properties, Protein structure, folding & function, Nitrogen Cycle Nitrogen Balance, Reductive.
Chapter 17 - Amino Acid Metabolism Metabolism of the 20 common amino acids is considered from the origins and fates of their: (1) Nitrogen atoms (2) Carbon.
Protein Metabolism. generation of metabolic energy A mino acids, through their oxidative degradation, make a significant contribution to the generation.
Amino acid oxidation and the production of urea Nitrogen excretion and the urea cycle Degradation of carbon skeleton of amino acids.
AMINO ACIDS METABOLISM Course: MEDICIMAL CHEMISTRY 1 Course Code: 301.
General pathways of amino acids transformation. General pathways of amino acids transformation.
Protein Metabolism 1 Denotes the various biochemical processes responsible for the synthesis of proteins and amino acids tthe breakdown of proteins.
Nitrogen Metabolism 1. Nitrogen Fixation 2. Amino Acid Biosynthesis.
Metabolism of amino acids, purine and pyrimidine bases Pavla Balínová.
Section M Nitrogen metabolism 1. Reduction of N 2 into ammonia (NH 3 or NH 4 + ) 2. Synthesis of the 20 amino acids. 3. Amino acid degradation.
BIOC/DENT/PHCY 230 LECTURE 5. glu UREA o synthesised mainly in liver o maintains N in a soluble, non-toxic form o transported in blood to kidney for.
Amino acid metabolism IV. Biosynthesis of nonessential amino acids Figures: Lehninger-4ed; fejezet: 22 (Stryer-5ed; fejezet: 24)
Amino Acid Catabolism Amino Acids 1.essential - excess are converted to metabolic intermediates such as: pyruvate, acetyl-CoA and are precursors for fatty.
Other metabolic pathways Pentose phosphate pathway (phosphogluconate pathway) Produces NADPH and ribose 5-phosphate Glc 6-phosphate + 2NADP + + H 2 O
Amino Acids Metabolism: Disposal of Nitrogen. - a.a can’t be stored, excess a.a (more than the needs of cells in the protein synthesis or other compound)
BIOC 460 DR. TISCHLER LECTURE 38 AMINO ACID DEGRADATION/ UREA CYCLE.
Amino acid metabolism COURSE TITLE: BIOCHEMISTRY 2 COURSE CODE: BCHT 202 PLACEMENT/YEAR/LEVEL: 2nd Year/Level 4, 2nd Semester M.F.Ullah,Ph.D.
Section 8. Amino Acid Metabolism Urea cycle 11/18/05.
LEHNINGER PRINCIPLES OF BIOCHEMISTRY Fifth Edition David L. Nelson and Michael M. Cox © 2008 W. H. Freeman and Company CHAPTER 18 Amino Acid Oxidation.
TUMS Dr. Azin Nowrouzi Tehran University of Medical Sciences Dr. Azin Nowrouzi Tehran University of Medical Sciences.
Amino Acid Oxidation and the Production of Urea Chapter 18.
The Nitrogen Cycle nitrogenase Nitrite reductase Nitrate reductase.
Chapter 26 Amino Acids Metabolism Biosynthesis of Amino Acids Essential Amino Acids Ile Leu Lys Met Phe Thr Trp Val The amino acids can be grouped.
Amino Acid Metabolism 1: Nitrogen fixation and assimilation, amino acid degradation, the urea cycle Bioc 460 Spring Lecture 38 (Miesfeld) Urea is.
Protein Turnover and Amino Acid Catabolism. The Digestion and Absorption of Dietary Proteins Pepsin nonspecific maximally active at low pH of the stomach.
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