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Role of Amino Acids Protein monomeric units Energy source Precursors of other biological molecules Protein monomeric units Energy source Precursors of other biological molecules
3 In Mammals Plants and bacteria can produce all of them
Amino acids are precursors 4
8 Biosynthesis of Amino Acids The nitrogen cycle
9 Biosynthesis of Amino Acids Nitrogen Fixation -> Microorganism
10 Major Ammonium ion carrier Ammonium Ion Is Assimilated into Amino Acids Through Glutamate and Glutamine
11 Biosynthesis of Amino Acids
12 Biosynthesis of Amino Acids in Bacteria and Plants Essential ones are in bold letters
13 Biosynthesis of Amino Acids in Bacteria and Plants
14 Biosynthesis of Amino Acids: Transaminations Amino Acid 1 + -Keto Acid 2 Amino Acid 2 + -Keto Acid 1 Glutamate + - Ketoglutarate + Pyridoxal phosphate (PLP)- Dependent Aminotransferase
Products of Amino Acid Breakdown Glucogenic – Pyruvate – -Ketoglutarate – Succinyl-CoA – Fumarate – Oxaloacetate Ketogenic – Acetyl-CoA – Acetoacetate
Animals cannot carryout net synthesis of precursors of gluconeogenesis from acetyl-CoA or acetoacetate
17 Amino Acid Metabolism
18 Fate of the C-Skeleton of Amino Acids
19 Fate of the C-Skeleton of Amino Acids
20 Fate of the C-Skeleton of Amino Acids Aromatic amino acids need oxygenases + O 2
21 Fate of Nitrogen in Different Organism
Overall Urea Cycle (Liver)
Carbamyl Phosphate Synthetase (CPS) CPSI (Mitochondria) – Uses NH 3 – Urea Cycle CPSII (Cytosol) – Uses Glutamine – Pyrimidine Biosynthesis
Carbamyl Phosphate Synthetase (CPS) Mechanism
Activation of HCO 3 – by ATP
Displacement of Phosphate by NH 3
Phosphorylation of Carbamate by ATP
Ornithine Transcarbamylase (OTC) (Mitochondrion)
Citrulline Carrier (Ornithine Antiport)
Argininosuccinate Synthetase (Cytosol)
33 Ammonium Ion is Converted into Urea Urea cycle
34 The Urea Cycle is Linked to the Citric Acid Cycle NH 4 +
Section M Nitrogen metabolism
CHAPTER 20 PROTEIN METABOLISM. Nitrogen of Amino Acids nitrogens to be excreted are collected in glutamate which is oxidized to -ketoglutarate and NH.
Detoxification of ammonia and biosynthesis of urea. The basic features of nitrogen metabolism were elucidated initially in pigeons.
FCH 532 Lecture 20 Quiz on Wed. Amino acids (25 min)
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1 LECTURES CATABOLISM OF PROTEINS AND AMINO ACID NITROGEN DR SAMEER FATANI BIOCHEMISTRY (METABOLISM)
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Amino Acid Catabolism C483 Spring Which of the following is/are true statement(s) about glutamine and alanine? A) They are nitrogen donors in.
METABOIC FATE OF AMINO ACIDS. Intracellular proteases hydrolyze internal peptide bonds, of protein releasing peptides, which are then degraded to free.
1 Amino Acid Metabolism 1.Proteins are degraded to amino acids 2.Removal of nitrogen is first step in degradation 3.Ammonium is converted into urea 4.C-skeleton.
FCH 532 Lecture 22 Chapter 26: Amino acid metabolism
Digestion of Proteins 25.7 Degradation of Amino Acids 25.8 Urea Cycle Chapter 25 Metabolic Pathways for Lipids and Amino Acids.
Amino Acid Metabolism 1: Nitrogen fixation and assimilation, amino acid degradation, the urea cycle Bioc 460 Spring Lecture 38 (Miesfeld) Urea is.
Protein Turnover and Amino Acid Catabolism
Chemistry: An Introduction to General, Organic, and Biological Chemistry, Eleventh Edition Copyright © 2012 by Pearson Education, Inc. Chapter 18 Metabolic.
BIOC 460 DR. TISCHLER LECTURE 38 AMINO ACID DEGRADATION/ UREA CYCLE.
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