1. Gout

2. URIC ACID
Uric acid is a chemical created when the body breaks down substances called purines. Purines are found in some foods and drinks, such as liver, anchovies, mackerel, dried beans and peas, beer, and wine.
Most uric acid dissolves in blood and travels to the kidneys, where it passes out in urine. If your body produces too much uric acid or doesn't remove enough if it, you can get sick. High levels of uric acid in the body is called hyperuricemia.

3. Gout is a form of arthritis caused by having to much uric acid in body.
This overload can lead to crystals of uric acid
In the joints.
Once these crystals settle in the joints, it may
cause attacks of inflammation, or arthritis.

4. Gout will usually occur after years of uric acid crystal build up
Gout will usually occur after years of uric acid crystal build up. Gout symptoms commonly show up at the base of your big toe.
Podagra is an acute gout attack at the base of the big toe.
Other affected areas include wrists, ankles, knees and elbows. The most common gout symptoms are a sharp pain in the joint, a warm feeling, possible swelling and tenderness.

5. Causes Many factors contribute to hyperuricemia, including:
genetics, insulin resistance, renal insufficiency, obesity, diet, use of diuretics, and consumption of alcoholic beverages.
Causes of hyperuricemia can be classified into three functional types:
Increased production of uric acid
Decreased excretion of uric acid
Mixed type.

6. Purine chemicals in the body are converted to uric acid so try to avoid foods high in purine such as, liver, kidneys, shellfish and some breads. Meats and seafood will increase your risk for gout attacks.
Again, Alcohol, especially beer as well as corn syrup from soda as the fructose can increase the risk of gout attacks..

8. Medication for gout treatment come in 3 distinct forms.
1. Pain Relivers. Acetaminophen
2. Anti-inflammatory. There are non-steroidal drugs such as colchicine and corticosteroids. These are used to reduce inflammation in the joints.
3. Uric Acid reducers. These are gout medications that manage chronic metabolic derangement, which are the main causes for gout and hyperuricemia. This type of gout treatment will help to reduce the uric acid levels in the blood.

9. (Febuxostat 40/80mg Tablet)
FEBUS
(Febuxostat 40/80mg Tablet)

10. febuxostat– oral nonpurine xanthine oxidase inhibitor FDA approved in 2009 for gout and hyperuricemia
FDA approved doses are 40mg and 80mg.
Compared to allopurinol, was as good or superior in achieving goal of sUA <6.0.
Significant reduction in gout flares and tophi when sUA goal is maintained.

11. Febuxostat is one of the latest gout medications to arise on the scene to help manage chronic hyperuricemia.
This drug has been shown to be more effective for gout treatment than allopurinol for gout attacks in helping to shrink tophi deposits of uric acid especially in ears, elbows and fingers.
Febuxostat may be better for people with kidney issues.

12. FEBUXOSTAT: PHARMACOKINETICS
• Bioavailablity > 80% after oral administration
•Absortion minimally influenced by food
• Metabolized in the liver, excreted as inactive metabolites by the kidneys and through the bile
• No clinically relevant interactions have been observed with
•thiazides, warfarin or NSAIDs
•No significantly influence the metabolism in patients with Mild-to-moderate renal or liver insufficiency
Perez-Ruiz F, Future Rheumatol 2008.

13. Dose
The recommended starting dosage is 40 mg once daily. After two weeks, your healthcare provider should check your uric acid level (using a blood test). If your level is not sufficiently low (6 mg/dL or less), the dosage may be increased to 80 mg once daily.

14. Brand Name
Composition
Company
Packing
MRP `
FABULAS
Feboxostat 40mg
INTAS 10
135.25
Feboxostat 80mg
245.25
Feboxostat 120mg
326.00
FEBOXA
RANBAXY
99.00
150.00
FEBUCIP
CIPLA
90.00
160.00
ZURIG
ZYDUS CADILA 14