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Immune System Objectives – To select genes that are embryonic lethal Or accept bone marrow from other centres – Generate bone marrow chimeras Or generate.

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Presentation on theme: "Immune System Objectives – To select genes that are embryonic lethal Or accept bone marrow from other centres – Generate bone marrow chimeras Or generate."— Presentation transcript:

1 Immune System Objectives – To select genes that are embryonic lethal Or accept bone marrow from other centres – Generate bone marrow chimeras Or generate conditional mutants for EUCOMM allels – Analyse phenotypes of these mutants and Establish the course of embryonic lethality

2 Members of the Network Principal Investigator Werner Muller, University of Manchester, Faculty of Life Science, AV Hill Building, M13 9PT Manchester; Co-Investigators Immunology: Richard Grencis, Kathryn Else, Mark Travis, Sheena Cruikshank, Douglas Millar, Dr. Mat Hardman, Paul Lyons, Jim Middleton Immune Toxicology: Ian Kimber Neurobiology: Emmanuel Pinteaux, Stuart Allan Cardiology: Ludwig Neyses, Elizabeth Cartwright, Delvac Oceandy Developmental Biology: Mike Dixon, Kathryn Hentges Human Genetics: Yanick Crow Bioinformatics: Andy Brass, Robert Stevens Manchester Centre for Nuclear Hormone Research in Disease: David Ray

3 Example 1 Analysis of a B cell phenotype for an embryonic lethal mutation (polymerase beta)

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8 Example2 Analysis of a complex phenotype for an embryonic lethal mutation using conditional gene targeting (gp130)

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13 neurological, cardiac, hematopoietic, immunological, hepatic and pulmonary

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16 Immune System Objectives – To select genes that are embryonic lethal Or accept bone marrow from other centres – Generate bone marrow chimeras Or generate conditional mutants for EUCOMM allels – Analyse phenotypes of these mutants and Establish the course of embryonic lethality


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