Presentation on theme: "Tracheobronchomalacia"— Presentation transcript:
1 Tracheobronchomalacia The ugly, but treatable step-cousin of the COPD familyColin McKnight, MSIII, 2007
2 Presentation OutlineBrief review of “COPD” definition, epidemiology and economic costsTracheobronchomalaciaDefinitionPathophysiologyKnown epidemiology and natural historyEvolving methods of diagnosisNew treatment strategies and outcomesSignificanceProposed study design
3 COPD: An unpopular disease from the start An Interesting perspective from 1976:“Chonic bronchitis with it accompanying emphysema is a disease on which a good deal of wholly unmerited sympathy is frequently wasted. It is a disease of the gluttonous, bibulous, otiose, and obese and represents a well-deserved nemesis for these unlovely indulgences The majority of cases are undoubtedly due to surfeit and self-indulgence”Fletcher C, Peto R., Tinker C, Speizer FE. The natural history of chronic bronchitis and emphysema. New York: Oxford University Press, 1976.
5 How Far Have We Really Come Since 1976? Research of ‘tobacco induced’ cancers such as lung cancer, receive only 10-15% of that for breast or prostate cancer when dollars spent per death are examined*Perhaps our willingness to blame the health of our patients on smoking has presented us from a more sophisticated understanding of obstructive pulmonary physiology.*Dennis
6 Which Diseases Lead to Obstructive Pulmonary Physiology? A conglomeration of various pathophysiological processes, of which the treatment varies substantially:EmphysemaChronic BronchitisAsthmaBronchiectasisBronchiolitis obliteransTracheobronchomalacia
7 AssumptionsUnfortunately, patients with obstructive pulmonary physiology are often assumed to have emphysemaThis is particularly true for those who smoke cigarettesPicture
8 GOLD criteria for COPD diagnosis airflow limitationnot fully reversible.usually both progressiveUsually associated with an abnormal lung inflammatory response to noxious particles or gases*GOLD: Global initiative for Chronic Lung DiseaseCurrent GOLD definition of airflow limitation is FEV1:FVC ratio <70%Stage I: FEV1 > 80% Stage IIA: FEV %Stage IIB: FEV %Stage III: FEV1 < 30%
10 COPD “diagnosis”Individuals with irreversible obstructive pulmonary physiology and the following non-specific findings are unfortunately often lumped together under one “diagnosis”:DyspneaCoughSputum
11 COPD Epidemiology 2000 estimate was >10 million diagnosed in U.S. Millions more are undiagnosed.COPD is the fourth leading cause of chronic morbidity and mortality in the US and within a decade will surpass stroke to become the third leading cause of death
12 Current COPD treatments CorticosteroidsOxygenPreventionSmoking cessationvaccinationDilatorsAnticholinergicsB2-agonistsTheophylllineRehabilitation
13 Only Oxygen has been shown to improve mortality Current goals of treatment:Slow further progressionReduce exacerbation hospitalizationsMaximize activity
14 A Tremendous Burden The economic impact of COPD in the US: 1993: $23.9 Billion*Direct costs $14.7 billionIndirect costs $9.2 billion2002: $32.1 billion**Sullivan*National Heart and Lung Institute
15 Annual mean individual cost is $5,646* $2,000 for mild cases$16,000 for severe casesThis Probably underestimates true burden because COPD often not:“primary reason for hospital visit”“cause of death”*Wouters*Halpan
16 My FrustrationsCOPD expenditures represent a tremendous cost to a health care system that is already on the verge of collapse and does not provide basic services to a large proportion of the population.Treatments offer very little hope of improvement.Despite expensive new medications, relative gains are little.
17 Tracheomalacia and Tracheobronchial malacia Definition: Malacia = WeaknessTracheomalacia (TM) weakness of the tracheaTracheobronchomalacia (TBM) weakness of the trachea and main stem bronchi*This presentatin will focus on adult, acquired tracheobronchomalacia rather than the congenital form of the disease
18 Postulated Pathophysiology Flaccid posterior membranous wall of the trachea bows anteriorly during dynamic expiration in response to elevated intrathoracic, extratracheal pressure.This is a dynamic process that is accentuated by forced expiration, thus routine AP and Lateral chest radiographs often show no abnormality.
19 During inspiration, the trachea dilates and lengthens. Trachea cross sectionInspiration: Decreased extratracheal pressureDuring inspiration, the trachea dilates and lengthens.Normal tracheaTracheomalaciaExpiration: Increased extratracheal pressureA weakened posterior tracheal wall leads to an exaggeration of the normal narrowing during expiration.
20 EtiologyExcessive bowing is thought to be due to reduction/atrophy of the longitudinal elastic fibers of the pars membranacea or impaired cartilage integrity.Presumed causes of acquired TM/TBMTreacheostomyIntubationTobacco smokeRadiation/previus surgeryRecurrent infections (with or without cigarette smoking)
21 Symptoms of TM and TBMDyspneaCoughSputum ProductionMay have:Inspiratory wheezing/stridor“Barking seal cough”Multiple admissions for “asthma exacerbations” with only modest treatment resultsThese are non-specific, and very often attributed to:EmphysemaChronic BronchitisCigarette SmokingAsthma
22 This is an obscure, insignificant disease… Right???
24 Population studies indicate very significant prevalence within certain populations: -Jolinen et al reported finding TM in 50 of 214 patients (23%) with chronic bronchitis who were examined bronchoscopically-Palombini revealed that TBM may be present in 10-15% of patients who see a pulmonologist for chronic cough
25 Malacia epidemiology continued… The most recent epidemiological data comes from a Japanese study that demonstrated TBM was present 542 of 4,283 patients (12.7%) with pulmonary disease who underwent bronchoscopy. (72% of this study were between 50-80years old).It is generally accepted that TBM is seldom found in individuals without some evidence of obstructive lung disease* Ikeda
26 A Progressive diseaseTM and TBM have been shown in various studies to be progressive diseases. In one longitudinal study, of 94 patients with TM and TBM with an average follow-up period 5.2 years progression had occurred in 6 of 9 patients. Zero patients showed improvement of their malacia.It has been postulated that TM causes a defect in secretion clearing, allowing for pathology to spread down the bronchial tree.
27 A relatively good candidate for “COPD” intervention Thus, TM represents a progressive pathophysiologic process where it may be possible to avoid further progression.Unlike emphysema, chronic bronchitis, and bronchiolitis obliterans, the defect is discrete and localized.Thus, this disease offers a rare target for mechanical intervention of “COPD”.
28 3 Further QuestionsCan this TBM be diagnosed in reliable, non-invasive manner?Are there effective interventions available?Are these interventions cost effective?
29 Diagnosis Bronchoscopy is the established gold standard Generally accepted that 50% loss of tracheal lumen during expiration is diagnostic of TMABA: Cross section in a healthy control subject during inhalation (left), exhalation (middle) and forced exhalation. SIs change from .95 to 0.93 to .87.B: Tracings of a TBM patient showing bowing of the posterior membrane. SIs change from .95 to .65 to .14.*Loring
30 A Non-Invasive Method of Diagnosis Gilkeson showed in 2000 that the degree of TBM defined by bronchoscopy correlates very well with dynamic CT findings.Image A: axial CT showing trachea of normal caliberImage B: dynamic CT showing crescentric bowing of posterior membranous tracheaAB
31 Evolution of Diagnosis In 2003 Zhang et al showed that Dynamic CT was highly sensitive at detecting TBM.N= /10 TBM patients were identified by CT. 0/10 control subjects were falsely labeled with malacia.Additionally, Zhang showed that a low dose dynamic CT was statistically equal at detecting TBM, thus indicating that high dose CT is not necessary for TBM diagnosis.
32 Demonstration of Air Trapping Right: Dynamic expiratory CT at a similar level on the same patient. White arrows indicate areas of air trapping in this TBM patient.Left: End inspiratory CTZhang et al demonstrated that patients with TBM defined by dynamic expiratory CT have statistically more severe air trapping. This air trapping has been postulated to be worsened in TBM patients from difficulties clearing secretions. Secretions are though to accumulate, thus inducing chronic inflammation of small airways, leading to air trapping.*Zhang, 2003
33 Use of PFTs in Diagnosis? -The degree of obstruction indicated by FEV1 does not correlate well with presence of TBM.-In TBM patients there is often a rapid decline in the maximal expiratory flow after a sharp peak associated with the collapse of central airways due to negative transmural pressure.PFTs therefore can be useful in raising suspicion of TBM, but they are not diagnostic.Flow volume loop in TM patient.*Carden
34 StentingMetal stents can be placed by bronchoscopy. They can expand dynamically and preserve mucociliary function, though breakage has caused severe complications, including death.Silicone stents can be easily repositioned and removed.Trials including stented patients have shown that stents lead to subjective and objective improvement in respiratory symptoms.Further larger trials are needed.
35 TracheoplastyCurrent methods call for surgical reinforcement of the posterior membranous wall with tracheoplasty enhancing the rigidity of the structure making it less susceptible to bowing during expiration.
36 Benefits of Tracheoplasty Wright et al, 2005n=14Significantly increasedmean forced expiratory volume (p=.009)peak flow rate (p=.00001)All patients had decreasedDyspneaCoughsecretion retention andAll reported increased activityBaroni RH, 2004N=5All showed a normal shaped trachea during inspiration following treatment4/5 showed normal shape on expirationAll patients reported subjective improvement in symptoms0/5 experience significant complications
37 Dynamic CT Demonstration of Improvement Following Tracheoplasty A: Preoperative end inspiratoryB: Preoperative dynamic expiratoryC: Postoperative end-inspiratoryD: Postoperative dynamic expiratoryABDC*Baroni
38 PFT Change Following Tracheoplasty Preoperative2 Months PostoperativeFlow volume curves in a 57-year-old man with 7 years of progressive dyspnea, wheezing, cough, and respiratory infections.*Wright
39 Further Benefits of TBM Diagnosis and Treatment Best evidence indicates depression is present in % of COPD patients.28% of COPD patients say they are embarrassed about the disease, and the same number say they feel defeated (particularly women and younger patients).An overwhelming portion of patients believe they brought on the disease because of a smoking habit. guilt, stigma, reinforcementPatients with TBM are often labeled as smokers after being “diagnosed” with emphysema. This can lead to insurance companies denying claims on the grounds of “false indication of non-smoking status.”*Norwood
40 TBM Review: A bigger problem than our medical system realizes: COPD: >$30 billion annually…TBM likely present in 10% of > 12 million COPD patients, whose current treatment is annually greater than $5,000. TBM is likely contributing significantly to the obstructive physiology in many of these individuals.TBM is a progressive disease that can be identified non-invasively through low dose dynamic CT.Tracheoplasty has been shown in small trials to substantially improve objective and subjective outcomes.
41 An opportunity…Given the extraordinary chronic costs of “COPD” therapy, and the great potential for localized defect correction, it is possible that tracheoplasty represents a rare opportunity to both reduce medical costs and improve clinical outcome.Further studies are needed to define who would benefit from TBM diagnostics and therapeutic intervention.
42 Study Proposal Involving the following investigators: Internists/PulmonologistsRadiologistsThoracic Surgeon
43 Initial Enrollment Internists/Pulmonologists: Identify TBM candidates to be selected for treatment.Candidates would be selected from a pool of COPD/asthmatics with long history of modest treatment benefit.Enrollment of individuals with dyspnea, great difficulty clearing secretions and barking cough will be emphasized.A functional pulmonary baseline will be established.
44 Radiologic Diagnosis Radiologists: Conduct low dose dynamic CT to identify TBM patients.Defect will be described in terms of level, % obstruction and presence/severity of air trapping.
45 Treatment phase Thoracic Surgeon: Of population with TBM defined by dynamic CT, ½ will undergo corrective tracheoplasty.½ will have “dummy” procedure.Patients, internists and follow up radiologists will be blinded to procedure status.
46 Data CollectionFollowing procedure, blinded patients will provide 5 years of subjective data.Blinded radiologists will perform postoperative dynamic CT to assess objective status of TBM 3 months after surgery.The patient’s respective internists/pulmonologist will measure objective outcomes for 5 years.Strict attention will be paid to cost of care.The following endpoints of the control and treatment arms will be compared:subjective activity and wellness levelsexacerbation frequency/severity% tracheal/bronchial obstruction, presence and severity of air trappingPFT scoresNeed for oxygenmortalitycost of care
48 References:Gilkeson, RC, Ciancibello, LM, Hejal, RB, et al Tracheobronchomalacia: dynamic airway evaluation with multidetector CT. AJR Am J Roentgenol 2001;176,Zhang, J, Hasegawa, I, Feller-Kopman, D, et al Dynamic expiratory volumetric CT imaging of the central airways: comparison of standard-dose and low-dose techniques. Acad Radiol 2003;10,Boiselle, PM, Feller-Kopman, D, Ashiku, S, et al Tracheobronchomalacia: evolving role of dynamic multislice helical CT. Radiol Clin North Am 2003;41,Zhang, J, Hasegawa, I, Hatabu, H, et al Frequency and severity of air trapping at dynamic expiratory CT in patients with tracheobronchomalacia. AJR Am J Roentgenol 2004;182,81-85Jokinen, K, Palva, T, Sutinen, S, et al Acquired tracheobronchomalacia. Ann Clin Res 1977;9,52-57Ikeda, S, Hanawa, T, Konishi, T, et al Diagnosis, incidence, clinicopathology and surgical treatment of acquired tracheobronchomalacia. Nihon Kyobu Shikkan Gakkai Zasshi 1992;30,Carden KA, Boiselle PM, Waltz DA, Ernst A Tracheomalacia and tracheobronchomalacia in children and adults: an in-depth review. Chest ;127(3):Baroni RH, Ashiku S, Boiselle PM Dynamic CT Evaluation of the central airways in patients undergoing tracheoplasty for tracheobronchomalacia. AJR Am J Roentgenol. 2005;184(5):1444-9Wright CD, Hermes GC, Hammoud ZT, Wain JC, Henning GA, Zaydfudim V, Mathisen DJ Tracheoplasty for expiratory collapse of central airways. Ann Thorac Surg Jul;80(1):259-66Mannino DM, Braman S The epidemiology and economics of chronic obstructive pulmonary disease. Proc Am Thorac Soc Oct 1;4(7):502Viegi G Epidemiology of chronic obstructive pulmonary disease (COPD). Respiration. 2001;68(1):4-19.Sullivan SD, Ramsey SD, Lee TA. The economic burden of COPD. Chest 2000;117:5S–9SHalpern MT, Stanford RH, Borker R. The burden of COPD in the U.S.A.: results from the Confronting COPD survey. Respir Med 2003;97:S81–S89