1. 25I-NBOMe
25i, Smiles, N-Bomb
ABC News 4 Story

2. 25i
25I-NBOMe had no history of recreational use prior to being sold online as a designer drug in 2010
Slang names for the drug now include “25I”, “Smiles”, and “N-bomb”
As a recreational drug, 25I-NBOMe is roughly as potent as and similar in effect to LSD
The drug is sometimes misrepresented on blotter paper as LSD
The chemical has emerged as a recreational drug in Europe and the United States as well as Australia.

3. 25i Administration
25I-NBOMe is inactive orally, and the most common methods of administration are sublingual, buccal, or nasal.
The drug is frequently loaded onto paper tabs, which are administered under the tongue or in the buccal space of the mouth. [
There are also reports of intravenous injection of dissolved 25I-NBOMe and smoking the drug in powdered form.

4. 25i Dosage 25I-NBOMe is potent, being active in sub-milligram doses.
A common dose of the hydrochloride salt is 600–1,200 µg
Erowid tentatively suggests that the threshold dosage for humans is 50–250 µg, with a light dose between 200–600 µg, a common dose at 500–800 µg, and a strong dose at 700–1500 µg.
At this level of potency, it is difficult to accurately measure a single dose of the powder form, and attempting to do so may put the user at risk of overdose.

6. 25i Effects
25I-NBOMe effects usually last 6–10 hours if taken sublingually or buccally. When it is insufflated, effects usually last 4–6 hours. Effects can however last significantly longer depending on dosage; durations longer than 12 hours have been reported.
25I-NBOMe can also be vaporized and inhaled, this may cause significantly quicker effects and shorter duration as is expected from that route of administration. This route of administration is however not recommended, unless when using precise liquid measurement, due to the difficulties of measuring and handling substances active in the microgram range.

7. 25i Effects
Desired
strong open- and closed-eye visuals, including trails, color shifts, brightening, etc.
mood lift
euphoria
mental and physical stimulation
increase in associative & creative thinking
increased awareness & appreciation of music
life-changing spiritual experiences
feelings of love and empathy
increased pattern recognition
brings on synesthesia and chromesthesia in users who normally don't experience such phenomena, or intensifying it in people who already have the condition

8. 25i Effects Neutral general change in consciousness pupil dilation
unusual body sensations (paresthesia, flushing, chills, goose bumps)
change in perception of time, time dilation
increased heart rate
jaw clenching
yawning, especially when coming up
bruxism

9. 25i Effects Undesired confusion and difficulty focusing
scrambled communication
vasoconstriction
shaking
clonus
nausea and vomiting (normally only during the onset; in the experience of some this occurs with every use, whereas in others never at all)
insomnia
looping, recursive, out-of-control thinking
paranoia, fear, and panic
unwanted and overwhelming feelings or life-changing spiritual experiences
fainting
dystonia
seizure

10. 25i Related Deaths
As of May 2013, 25I-NBOMe has reportedly led to five overdose deaths in the United States.
In June 2012, two teens in Grand Forks, North Dakota and East Grand Forks, Minnesota fatally overdosed on a substance that was allegedly 25I-NBOMe, resulting in lengthy sentences for two of the parties involved and a Federal indictment against the Texas based online vendor.
A 21-year-old man from Little Rock, Arkansas died in October 2012 after taking a liquid drop of the drug nasally at a music festival. He was reported to have consumed caffeinated alcoholic beverages for “several hours” beforehand. It is unclear what other drugs he may have consumed, as autopsies generally do not test for the presence of research chemicals.
In January 2013, an 18 year-old in Scottsdale, Arizona, died after consuming 25I-NBOMe sold as LSD; a toxicology screening found no other drugs in the person's system. The drug is the suspected cause of death in another Scottsdale, Arizona, incident in April 2013.

11. 25i Drug Prohibition
25I-NBOMe is unscheduled under United States federal law. However, it could be considered an analog of 2C-I (a Schedule I controlled substance) under the Federal Analogue Act. In this case, sale or possession of 25I-NBOMe with the intent of human consumption would be illegal. The United States Department of Homeland Security is currently attempting to prosecute someone in federal court with 25I-related charges under the analogue act (unconfirmed).