2 25i25I-NBOMe had no history of recreational use prior to being sold online as a designer drug in 2010Slang names for the drug now include “25I”, “Smiles”, and “N-bomb”As a recreational drug, 25I-NBOMe is roughly as potent as and similar in effect to LSDThe drug is sometimes misrepresented on blotter paper as LSDThe chemical has emerged as a recreational drug in Europe and the United States as well as Australia.
3 25i Administration25I-NBOMe is inactive orally, and the most common methods of administration are sublingual, buccal, or nasal.The drug is frequently loaded onto paper tabs, which are administered under the tongue or in the buccal space of the mouth. [There are also reports of intravenous injection of dissolved 25I-NBOMe and smoking the drug in powdered form.
4 25i Dosage 25I-NBOMe is potent, being active in sub-milligram doses. A common dose of the hydrochloride salt is 600–1,200 µgErowid tentatively suggests that the threshold dosage for humans is 50–250 µg, with a light dose between 200–600 µg, a common dose at 500–800 µg, and a strong dose at 700–1500 µg.At this level of potency, it is difficult to accurately measure a single dose of the powder form, and attempting to do so may put the user at risk of overdose.
6 25i Effects25I-NBOMe effects usually last 6–10 hours if taken sublingually or buccally. When it is insufflated, effects usually last 4–6 hours. Effects can however last significantly longer depending on dosage; durations longer than 12 hours have been reported.25I-NBOMe can also be vaporized and inhaled, this may cause significantly quicker effects and shorter duration as is expected from that route of administration. This route of administration is however not recommended, unless when using precise liquid measurement, due to the difficulties of measuring and handling substances active in the microgram range.
7 25i EffectsDesiredstrong open- and closed-eye visuals, including trails, color shifts, brightening, etc.mood lifteuphoriamental and physical stimulationincrease in associative & creative thinkingincreased awareness & appreciation of musiclife-changing spiritual experiencesfeelings of love and empathyincreased pattern recognitionbrings on synesthesia and chromesthesia in users who normally don't experience such phenomena, or intensifying it in people who already have the condition
8 25i Effects Neutral general change in consciousness pupil dilation unusual body sensations (paresthesia, flushing, chills, goose bumps)change in perception of time, time dilationincreased heart ratejaw clenchingyawning, especially when coming upbruxism
9 25i Effects Undesired confusion and difficulty focusing scrambled communicationvasoconstrictionshakingclonusnausea and vomiting (normally only during the onset; in the experience of some this occurs with every use, whereas in others never at all)insomnialooping, recursive, out-of-control thinkingparanoia, fear, and panicunwanted and overwhelming feelings or life-changing spiritual experiencesfaintingdystoniaseizure
10 25i Related DeathsAs of May 2013, 25I-NBOMe has reportedly led to five overdose deaths in the United States.In June 2012, two teens in Grand Forks, North Dakota and East Grand Forks, Minnesota fatally overdosed on a substance that was allegedly 25I-NBOMe, resulting in lengthy sentences for two of the parties involved and a Federal indictment against the Texas based online vendor.A 21-year-old man from Little Rock, Arkansas died in October 2012 after taking a liquid drop of the drug nasally at a music festival. He was reported to have consumed caffeinated alcoholic beverages for “several hours” beforehand. It is unclear what other drugs he may have consumed, as autopsies generally do not test for the presence of research chemicals.In January 2013, an 18 year-old in Scottsdale, Arizona, died after consuming 25I-NBOMe sold as LSD; a toxicology screening found no other drugs in the person's system. The drug is the suspected cause of death in another Scottsdale, Arizona, incident in April 2013.
11 25i Drug Prohibition25I-NBOMe is unscheduled under United States federal law. However, it could be considered an analog of 2C-I (a Schedule I controlled substance) under the Federal Analogue Act. In this case, sale or possession of 25I-NBOMe with the intent of human consumption would be illegal. The United States Department of Homeland Security is currently attempting to prosecute someone in federal court with 25I-related charges under the analogue act (unconfirmed).