1. Terpene-based Manufacturing for Sustainable Chemical Feedstocks

2. An Abundant Resource

3. A Renewable Hydrocarbon Platform

4. A Multi-disciplinary Project

5. Chemistry at the centre

7. Chemistry at the centre

8. Exemplary demonstration
A sustainable synthesis of 'green' paracetamol from limonene
Classical petrochemical based synthesis:
30 million packs sold in UK every year
180,000 t/yr global production
All 8 carbons from parent skeleton of limonene
Scalable, catalytic flow-synthesis (Kg scale)

9. Limonene to Paracetamol
Proposed synthetic route:

10. Limonene to Paracetamol
Current progress:

11. Limonene to Paracetamol
Current progress:

12. Limonene to Paracetamol
Current progress:

13. Limonene to Paracetamol
Current progress:

14. Limonene to Paracetamol
Current progress:

15. Acknowledgments Chemistry Chemical Engineering Biology
Matthew Davidson
Steven Bull
William Cunningham
Matthew Jones
Chris Frost
Janet Scott
Duncan Wass (University of Bristol)
Chemical Engineering
Massi Vezzoli
Pawel Plucinski
Darrel Patterson
Davide Mattia
Laura Torrente
Ulrich Hintermair
Biology
David Leak
Matthew Styles
Systems analysis and Pathways to Manufacture
(University of Cambridge, Institute for Manufacturing)
Alexei Lapkin
Jag Srai
Wouter Bam
Funding
Environment, Sustainability
and Energy Division

17. Limonene to Paracetamol