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Finger Plethysmograph For Measuring Blood Resistivity Client: John G. Webster, Ph.D Advisor: Thomas Yen, Ph.D. Team Tim Balgemann- Team Leader Lucas Vitzthum-

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Presentation on theme: "Finger Plethysmograph For Measuring Blood Resistivity Client: John G. Webster, Ph.D Advisor: Thomas Yen, Ph.D. Team Tim Balgemann- Team Leader Lucas Vitzthum-"— Presentation transcript:

1 Finger Plethysmograph For Measuring Blood Resistivity Client: John G. Webster, Ph.D Advisor: Thomas Yen, Ph.D. Team Tim Balgemann- Team Leader Lucas Vitzthum- Communications Nick Harrison- BSAC Tyler Lark- BWIG

2 Outline Background Problem Statement Theory Electrical Biological Concepts Design Components Circuit Design Mechanical Future Work

3 Diabetes Body’s inability to manage glucose levels Prevalence is on the rise 26.3 million in U.S. $116 billion excess medical expenditures annually No reliable non-invasive monitoring Hypothesized that blood sugar levels may be correlated with blood resistivity

4 Problem Statement Design a finger plethysmograph to measure blood resistivity Goals: Build a mechanical device to secure finger Design a circuit that allows data acquisition of blood impedance

5 Electrical Theory Four electrode impedance plethysmography 2 electrodes pass current through finger 2 electrodes measure voltage Signal processing Calculate impedance and resistivity from voltage output

6 Biological Theory High blood flow RBCs align, current meets little resistance Low blood flow RBCs misalign, greater resistance Impedance (ΔZ) results from this Change in volume of artery Saline solution cancels signal High FlowLow Flow

7 Design Specifications Circuit Sensitivity Adaptable measurement range (i.e. autoreset) Digital filtering and signal processing Mechanical Device Motion artifacts Minimal electrical signature

8 Circuitry Measuring change in blood resistivity Sample and Hold Filtering Current amplitude and frequency Data interpretation Webster J. G., 1998

9 Mechanical Design Restrain Finger Circulation Conductive Current Source Voltmeter

10 Restrain Designs Air in Side Inflatable Cuff Mesh Cage Bar Cage Top

11 Future Work Build prototype Optimize saline solution Current amplitude and frequency Circuit component values Testing Clinical Trials

12 References Webster J. G., 1998. Measurement of flow and volume of blood Medical Instrumentation: Application and Design, 3rd Edition ed J G Webster (New York: John Wiley & Sons). Rosenthal, J. H., An inductive plethysmograph for ambulatory ventilation measurement. American Diabetes Association: http://www.diabetes.org/diabetes- statistics.jsp World Health Organization: http://www.who.int/dietphysicalactivity/publications/facts/diabetes/e n/

13 Questions??


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