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Genetics Case Study: The Royal Family. The Romanov Family Romanov Empire included one-sixth of the globe. Nicholas II became Czar of Russia in 1896 Resentment.

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Presentation on theme: "Genetics Case Study: The Royal Family. The Romanov Family Romanov Empire included one-sixth of the globe. Nicholas II became Czar of Russia in 1896 Resentment."— Presentation transcript:

1 Genetics Case Study: The Royal Family

2 The Romanov Family Romanov Empire included one-sixth of the globe. Nicholas II became Czar of Russia in 1896 Resentment against the Czar and wealthy class begins at end of 19th century.

3 Alexei Born in 1904, Nicholas’s only son. Had hemophilia, a bleeding disorder. Had body guard with him at all times to prevent accidents. Alexei had several internal bleeding instances. These bleedings were stopped after the prayers of the healer Rasputin.

4

5 Rasputin Healer or Scoundrel???? Alexandra (Alexei’s mom) called Rasputin in to stop Alexei’s bleeding. Alexandra took Rasputin in as a relative (which lowered public faith of the Romanov family). His influence on the Czar is arguable by historians. Assassinated by Russian aristocrats.

6 Rasputin Rasputin was drugged, poisoned, and shot before he died of drowning in the Neva river

7 End of the Empire July, 1918: Russian Revolution (Romanov’s assassinated) Alexei’s body missing from mass grave found in 1990’s.

8 So what does this have to do with Genetics? Learn how to read a PEDIGREE. Learn the inheritance pattern of HEMOPHILIA.

9 Sex-Linkage Traits controlled by genes located on the sex chromosomes are called sex-linked traits. The gene for a protein that helps blood clot is on the X chromosome. If this gene is mutated (deletion, point mutation, etc), it may cause HEMOPHILIA. Heterozygotes are carriers & may pass trait on to children, but themselves appear normal. Other sex-linked traits are red-green colorblindness, Duchenne muscular dystrophy, and Fragile X syndrome.

10 Royal Family Pedigree

11 Pedigrees Each row represents a generation Genders represented by different shapes Affected individuals indicated by shading Carriers indicated by half shading

12 Reading a Pedigree Sometimes, carriers are indicated this way.

13 Pedigree Problems: Tips Recessive: trait usually skips a generation Dominant: trait shows up often Autosomal: trait seen in both genders Sex-linked: trait seen usually in 1 gender

14 Sample Pedigrees

15 Pedigree Practice Dominant or recessive trait? Autosomal or sex-linked?

16 Pedigree Practice Dominant or recessive trait? Autosomal or sex-linked?

17 Pedigree Practice Dominant or recessive? Autosomal or Sex-linked?

18 Practice Problems s_semesters/Bio103_Su2004/Links_of_Inte rest/links_to_practice_pedigree_probs.htmhttp://www.yhc.edu/external/jasonb/previou s_semesters/Bio103_Su2004/Links_of_Inte rest/links_to_practice_pedigree_probs.htm

19 Create your own pedigree! 1.Draw your family tree like the pedigrees we’ve seen. 2.Decide on a trait, and shade the affected individuals. (see list of traits on next slide) 3.Show the trait through 3 generations in your family (grandparents, parents, and you and your siblings).

20 DominantRecessive Widow’s peak hairlineStraight hairline Tongue-rollingCan’t roll tongue Free earlobesAttached earlobes Can’t bend back 45°Hitchhiker’s thumb FrecklesNo freckles No chin cleftChin cleft Bent little fingerNot bent Oval faceSquare face Morton’s Toe(2 nd toe)Big Toe is tallest Dark hair (brown/black)Blonde Hair Not red hairRed Hair


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