2 The Romanov Family Romanov Empire included one-sixth of the globe. Nicholas II became Czar of Russia in 1896Resentment against the Czar and wealthy class begins at end of 19th century.
3 Alexei Born in 1904, Nicholas’s only son. Had hemophilia, a bleeding disorder.Had body guard with him at all times to prevent accidents.Alexei had several internal bleeding instances.These bleedings were stopped after the prayers of the healer Rasputin.
5 Rasputin Healer or Scoundrel???? Alexandra (Alexei’s mom) called Rasputin in to stop Alexei’s bleeding.Alexandra took Rasputin in as a relative (which lowered public faith of the Romanov family). His influence on the Czar is arguable by historians.Assassinated by Russian aristocrats.
6 RasputinRasputin was drugged, poisoned, and shot before he died of drowning in the Neva river
7 End of the EmpireJuly, 1918: Russian Revolution (Romanov’s assassinated)Alexei’s body missing from mass grave found in 1990’s.
8 So what does this have to do with Genetics? Learn how to read a PEDIGREE.Learn the inheritance pattern of HEMOPHILIA.
9 Sex-LinkageTraits controlled by genes located on the sex chromosomes are called sex-linked traits.The gene for a protein that helps blood clot is on the X chromosome.If this gene is mutated (deletion, point mutation, etc), it may cause HEMOPHILIA.Heterozygotes are carriers & may pass trait on to children, but themselves appear normal.Other sex-linked traits are red-green colorblindness, Duchenne muscular dystrophy, and Fragile X syndrome.
19 Create your own pedigree! Draw your family tree like the pedigrees we’ve seen.Decide on a trait, and shade the affected individuals. (see list of traits on next slide)Show the trait through 3 generations in your family (grandparents, parents, and you and your siblings).
20 DominantRecessiveWidow’s peak hairlineStraight hairlineTongue-rollingCan’t roll tongueFree earlobesAttached earlobesCan’t bend back 45°Hitchhiker’s thumbFrecklesNo frecklesNo chin cleftChin cleftBent little fingerNot bentOval faceSquare faceMorton’s Toe(2nd toe)Big Toe is tallestDark hair (brown/black)Blonde HairNot red hairRed Hair