2The Romanov Family Romanov Empire included one-sixth of the globe. Nicholas II became Czar of Russia in 1896Resentment against the Czar and wealthy class begins at end of 19th century.
3Alexei Born in 1904, Nicholas’s only son. Had hemophilia, a bleeding disorder.Had body guard with him at all times to prevent accidents.Alexei had several internal bleeding instances.These bleedings were stopped after the prayers of the healer Rasputin.
5Rasputin Healer or Scoundrel???? Alexandra (Alexei’s mom) called Rasputin in to stop Alexei’s bleeding.Alexandra took Rasputin in as a relative (which lowered public faith of the Romanov family). His influence on the Czar is arguable by historians.Assassinated by Russian aristocrats.
6RasputinRasputin was drugged, poisoned, and shot before he died of drowning in the Neva river
7End of the EmpireJuly, 1918: Russian Revolution (Romanov’s assassinated)Alexei’s body missing from mass grave found in 1990’s.
8So what does this have to do with Genetics? Learn how to read a PEDIGREE.Learn the inheritance pattern of HEMOPHILIA.
9Sex-LinkageTraits controlled by genes located on the sex chromosomes are called sex-linked traits.The gene for a protein that helps blood clot is on the X chromosome.If this gene is mutated (deletion, point mutation, etc), it may cause HEMOPHILIA.Heterozygotes are carriers & may pass trait on to children, but themselves appear normal.Other sex-linked traits are red-green colorblindness, Duchenne muscular dystrophy, and Fragile X syndrome.
19Create your own pedigree! Draw your family tree like the pedigrees we’ve seen.Decide on a trait, and shade the affected individuals. (see list of traits on next slide)Show the trait through 3 generations in your family (grandparents, parents, and you and your siblings).
20DominantRecessiveWidow’s peak hairlineStraight hairlineTongue-rollingCan’t roll tongueFree earlobesAttached earlobesCan’t bend back 45°Hitchhiker’s thumbFrecklesNo frecklesNo chin cleftChin cleftBent little fingerNot bentOval faceSquare faceMorton’s Toe(2nd toe)Big Toe is tallestDark hair (brown/black)Blonde HairNot red hairRed Hair