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Published byJarod Yelvington Modified about 1 year ago

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Supplemental Figure 1

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Supplemental Figure 2

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Supplemental Figure 3 A B

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OCI-AML3 IgG ControlControl nM SP2509, 24 h CD86 MOLM13 CD86 Supplemental Figure 4 A B

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MV4-11 SP PS combination indices SP2509PSFaCI(nM) MV4-11 SP PS Fractional Effect CI C Supplemental Figure 5 OCI-AML3 SP PS combination indices SP2509PSFaCI(nM) MOLM13 SP PS combination indices SP2509PSFaCI(nM) A B Primary CD34+ CD38- Lin- AML combination indices SP2509 (nM) PS (nM) FaCI D

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B * OCI-AML3 p21 p16 EZH2 C/EBPα p42 C/EBPα p30 LSD1 SUZ12 β-Actin 250 nM SP2509, 96 h 5 nM PS, 96 h A Supplemental Figure 6

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Supplemental Figure 7 Primary AML SP2509 and PS SP2509 (nM) PS (nM) EffectCI A B

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