Download presentation
Presentation is loading. Please wait.
Published byChana Wiginton Modified over 9 years ago
1
Is this specific for zebrafish? Or can we learn how to drive stem cells into specific cell types in mammals?
2
Overexpression of mouse Pou5f1 rescues zebrafish embryos mutant for Pou5f1 Evolutionary conservation of function
3
Mouse and zebrafish Pou5f1 share targets: Comparison with mouse Oct4 target sets (genes with homology info only): Sharov et al, BMC Genomics 2008 (Matoba et al., 2006 and Loh et al., 2006) 453 49 406 zebrafish mouse
5
Relevance?
6
Insight into controlled differentiation of stem cells to replace lost tissues: Regenerative medicine Use knowledge of combination of tissue specific repressors of differentiation to generate defined cell types
7
Acknowledgements & Rebecca Mössner, Kay Kotkamp, Bozena Polock, Björn Wendik, Esther Kur, Bernadette Lippok, Sungmin Song, Heinz-Georg-Belting, Martina Lachnit Collaborations: Thorsten Kurz (ZBSA Genomics Core) driever@biologie.uni-freiburg.de Daria Onichtchouk Florian Geier Jens Timmer (FRIAS) Onichtchouk et al., Molecular Systems Biology, 6:354 Mar 9 - 2010
Similar presentations
© 2024 SlidePlayer.com Inc.
All rights reserved.