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Is this specific for zebrafish? Or can we learn how to drive stem cells into specific cell types in mammals?

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Presentation on theme: "Is this specific for zebrafish? Or can we learn how to drive stem cells into specific cell types in mammals?"— Presentation transcript:

1 Is this specific for zebrafish? Or can we learn how to drive stem cells into specific cell types in mammals?

2 Overexpression of mouse Pou5f1 rescues zebrafish embryos mutant for Pou5f1 Evolutionary conservation of function

3 Mouse and zebrafish Pou5f1 share targets: Comparison with mouse Oct4 target sets (genes with homology info only): Sharov et al, BMC Genomics 2008 (Matoba et al., 2006 and Loh et al., 2006) zebrafish mouse

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5 Relevance?

6 Insight into controlled differentiation of stem cells to replace lost tissues: Regenerative medicine Use knowledge of combination of tissue specific repressors of differentiation to generate defined cell types

7 Acknowledgements & Rebecca Mössner, Kay Kotkamp, Bozena Polock, Björn Wendik, Esther Kur, Bernadette Lippok, Sungmin Song, Heinz-Georg-Belting, Martina Lachnit Collaborations: Thorsten Kurz (ZBSA Genomics Core) Daria Onichtchouk Florian Geier Jens Timmer (FRIAS) Onichtchouk et al., Molecular Systems Biology, 6:354 Mar

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