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Title Chapter 13 Gene regulation. CO 13 Fig. 13.1.

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Presentation on theme: "Title Chapter 13 Gene regulation. CO 13 Fig. 13.1."— Presentation transcript:

1 Title Chapter 13 Gene regulation

2 CO 13

3 Fig. 13.1

4 Fig. 13.3

5 Fig. 13.4

6 Fig. 13.4a

7 Fig. 13.4b

8 Fig. 13.5

9 Fig. 13.5a

10 Fig. 13.5b

11 Fig. 13.6

12 Fig. 13.6a

13 Fig. 13.6b

14 Fig. 13.7

15 Fig. 13.7a

16 Fig. 13.7b

17 Fig. 13.8

18 Fig. 13.8a

19 Fig. 13.8b

20 Fig. 13.9

21 Fig

22 Fig

23 Fig

24 Fig

25 Fig

26 Fig

27 Fig

28 Fig

29 Fig

30 Fig

31 Fig a

32 Fig b

33 Fig c

34 Fig d

35 Fig Repressible operon Anabolic enzyme corepressor

36 Fig a

37 Fig b

38 Fig Regulation of transcription in eukaryotes 3 features: Basal transcription Some RE: Enhancers or silencers

39 Fig General transcription factors Core promoter

40 Fig Activators 2. repressors 3. compaction of DNA

41 Fig Gene accessibility is controlled by changes in chromatin structure Activators: Histone acetyltransferase (acetyl group, ---COCH3) ATP-dependent chromatin remodeling enzymes: to loosen the compaction of chromatin

42 Fig Steroid hormones exert their effects by binding to a regulatory transcription factors and controlling the transcription of near genes Nuclear localization signals Glucocorticoid response element

43 Fig Structure features of regulatory transcription factors allow them to bind to DNA

44 Fig a

45 Fig b

46 Fig c

47 Fig d

48 Page 272 DNA methylation inhibits gene transcription DNA methylase CpG island: near promoter 1.Prevent an activator binding 2.Inhibit open conformation:

49 Fig Regulation of RNA processing and translation in eukaryotes Alternative splicing of pre-mRNA: creats protein diversity.

50 Fig MicroRNAs inhibit mRNA by translastional repression or mRNA degradation Micro RNA: miRNA enzyme RNA-induced silencing complex(RISC) RNA interference (RNAi):

51 Fig Iron:vital and toxic  ferritin: store excess iron.

52 Fig a

53 Fig b


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