Fig Regulation of transcription in eukaryotes 3 features: Basal transcription Some RE: Enhancers or silencers
Fig General transcription factors Core promoter
Fig Activators 2. repressors 3. compaction of DNA
Fig Gene accessibility is controlled by changes in chromatin structure Activators: Histone acetyltransferase (acetyl group, ---COCH3) ATP-dependent chromatin remodeling enzymes: to loosen the compaction of chromatin
Fig Steroid hormones exert their effects by binding to a regulatory transcription factors and controlling the transcription of near genes Nuclear localization signals Glucocorticoid response element
Fig Structure features of regulatory transcription factors allow them to bind to DNA
Page 272 DNA methylation inhibits gene transcription DNA methylase CpG island: near promoter 1.Prevent an activator binding 2.Inhibit open conformation:
Fig Regulation of RNA processing and translation in eukaryotes Alternative splicing of pre-mRNA: creats protein diversity.