2Sickle cell anemia is a genetic disorder that affects the shape of a human’s red blood cells. A normal red blood cell is round and can easily move through the narrow blood vessels.People with the disorder have red blood cells that are in sickle shape. It is harder for the cells to travel through the vessels and can cause a buildup.The disorder affects the molecule hemoglobin, which aids in the delivery of oxygen to cells.Hemoglobin S is the result of the genetic disorder which disfigures the cell into its sickle, or crescent, shape.
3Regular Red Blood Cells Red Blood Cells with Sickle Cell anemia
4Expression of sickle cell anemia The sickle cell mutation is on chromosome 11 which codes for the beta unit of hemoglobin. The effects of the sickled shape of the cells causes organ damage and pain.Due to the buildup of red blood cells in the blood vessels, oxygen is prohibited from arriving in organs such as the spleen, liver, kidneys, lungs, heart, and other vital organs. The organs will ultimately fail if they don’t receive the necessary oxygen.The genetic disorder can also cause slowed growth, strokes, paleness, fatigue and abdominal pain.People have a dangerously low count of red blood cells (anemia) which gives the disease its name.People in the past with the disorder were not expected to live past childhood but due to advances in medical care, they have a higher chance of living past childhood.
5Inheritance of Sickle cell anemia The inheritance of sickle cell anemia is by autosomal recessive patterns where the offspring cannot inherit the disease unless it receives the mutated gene from both of its parents.People who have only one copy of sickle cell trait are known to be carriers of it. They aren’t diagnosed with the disease and have no symptoms of the genetic disorder. However, they can pass the gene to their offspring.The disease most frequently affects African Americans in the United States (1 out of 500). Sickle cell anemia is most common among residents from Africa, Middle East, Mediterranean and the Caribbean because the carriers of the hemoglobin mutation are far more resistant to the disease malaria.