Presentation on theme: "Morphology of RCB in health and disease Hematology CLS 531 Prepared by: Hajar AlQadeeb."— Presentation transcript:
Morphology of RCB in health and disease Hematology CLS 531 Prepared by: Hajar AlQadeeb
Objectives Discuss the procedure for proper red blood cell examination with respect to: – objective(s) used – area examined Discuss various aspects of red cell morphology related to cell size Discuss various aspects of red cell morphology related to cell color. Discuss various aspects of red cell morphology related to cell shape.
Normal RBC Size: Normocyte Colour: Normochromic
Rouleax formation (thick part of film)
Variation in size Anisocytosis
Variation in shape Poikilocytosis
Variation in size Macrocyte Megaloplastic anemia, liver disease
Variation in size Microcyte Iron deficiency anemia, Thalasimia,and Sidroblastic anemia
Variation in shape Elleptocytosis: Elleptocyte= Rod-like
Variation in shape Schistocyte= RBC fragment
2 1 1)Sickled cell Variation in shape variation in colour 2)Target cell Sickle cell anemia
Variation in shape Burr cells (Echinocytes) Found in Uremia and Pyruvate kinase deficiency.
Variation in shape Poikilocyte = Pear or tear shaped
Variation in size:Microcyte Variation in colour: A)Target cell B)Hypochrmatic Iron deficiency anemia
Variation in content Nucleated RBC= late normoblast
Variation in content Basophilic stippling or RBC stippling
Variation in content Reticulocyte = immature RBC
Variation in content Heinz body Found in G6PD deficiency anemia.