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Pure Science. Innovative Thinking. Unparalleled Quality 1 What is VESIsorb ® ? Naturally self-assembling colloidal delivery system that enables us to meet.

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Presentation on theme: "Pure Science. Innovative Thinking. Unparalleled Quality 1 What is VESIsorb ® ? Naturally self-assembling colloidal delivery system that enables us to meet."— Presentation transcript:

1 Pure Science. Innovative Thinking. Unparalleled Quality 1 What is VESIsorb ® ? Naturally self-assembling colloidal delivery system that enables us to meet the growing demand for enhanced bioavailability of unique science-based formulas taking their absorption and efficacy to the next level.

2 Pure Science. Innovative Thinking. Unparalleled Quality 2 Consistent advantage under all conditions Absorption & bioavailability impacted by – Aging population = nutrient absorption declines with age – Low-Fat Diet…see Omthera study Lovaza vs. Epanova – Sickness & Stress negatively impact absorption – More standard capsules = < efficient absorption Delivers Maximum Benefits

3 Pure Science. Innovative Thinking. Unparalleled Quality 3 Introducing VESIsorb® Ultimate Red Yeast Rice The VESIsorb® Ultimate Red Yeast Rice is a one-of-a kind formulation, never before available, with the most clinically proven, thoroughly tested, safe and efficacious combination of ingredients that deliver powerful benefits all in one patent-pending formulation.

4 Pure Science. Innovative Thinking. Unparalleled Quality 4 VESIsorb® Ultimate Red Yeast Rice No other red yeast rice formulation contains Cholesstrinol™HP which has been clinically proven to deliver natural support for healthy total cholesterol, LDL cholesterol, triglycerides, and HDL cholesterol. Cholesstrinol™HP delivers multiple heart health benefits working synergistically with the organic red yeast rice and CoQsource® coenzyme Q10, one of the most absorbable and bioavailable coenzyme Q10 formulations, in the patented VESIsorb® delivery system.

5 Pure Science. Innovative Thinking. Unparalleled Quality 5 What is Cholesstrinol ™ ? Cholesstrinol™ is an award winning platform of proprietary heart healthy formulas that tells a powerful brand story. It pulls together the detailed scientific data in an easy-to- understand package for the consumer reducing, if not eliminating, the need for laborious guesswork or research on their part. Branding these combinations under the name – Cholesstrinol™ – is designed to leverage their scientific basis. It is a widely scoped and all-encompassing platform that provides numerous targeted and customized solutions for consumers with specific cardiovascular concerns.

6 Pure Science. Innovative Thinking. Unparalleled Quality 6 Three Different and Complementary Mechanisms to Modify Cholesterol and Triglycerides 1. Polymethoxylated flavones (PMFs) decrease apoprotein B, a structural protein needed for endogenous synthesis of LDL cholesterol. Lipids, Vol 39. no2., 2004 Kurowski and Manthely., PMFs Tangeretin and Nobiletin decrease diacylglycerol acetyl transferase (DGAT), a liver enzyme needed for endogenous synthesis of triglycerides. Lipids, Vol 39. no2., Tocotrienols inhibit HMG CoA reductase, a liver enzyme needed for endogenous synthesis of cholesterol. Pearce et al., 1992; Parker et al., 1993; Qureshi et al., 1996

7 Pure Science. Innovative Thinking. Unparalleled Quality 7 ACETYL COA HMG-CoA Reductase GERANYL GERANIO GERANIOL FARNESOL PROTEINS CoQ10 CHOLESTEROL SYNTHESIS CoQ10 ↓ by statin May lead to ↓ energy Protein ↓ by statin May lead to myopathy STATIN X TOCOTRIENOL (Targets Farnesol) Down Regulates HMGCR HMGCR- INCREASE RATE OF NATURAL DEGRADATION HMG-CoA REDUCTASE

8 Pure Science. Innovative Thinking. Unparalleled Quality 8  Fatty acids Triglycerides DGAT LDL Lipoprotein Assembly Fatty AcidsTriglycerides X Nascent apo B MTP X Kurowska et al.,2004 ß-oxPPAR Fatty acids PMF Mechanism

9 Pure Science. Innovative Thinking. Unparalleled Quality 9 4-week Clinical Results -35% -30% -25% -20% -15% -10% -5% 0% TCLDLTGLDL / HDL I ΙΙ ΙΙΙ Multiple Clinical Study Summary % Reduction

10 Pure Science. Innovative Thinking. Unparalleled Quality 10 Exclusive Partnership with World Leader in Citrus Bioflavonoids and Polymethoxylated Flavones (PMFs) Through SourceOne’s exclusive partnership with Ingredients by Nature (IBN), the world leader in citrus extracts, we have established ourselves as the principal marketer of Citrus Bioflavonoids and PMFs with multiple products, including our award-winning Cholesstrinol Family of Heart Healthy Formulas. – Over 80 years of analytical experience and expertise. – New showcase facility and on-site state-of-the-art laboratory. – Formulation expertise through proprietary blending granulation and state of the art sterilization.

11 Pure Science. Innovative Thinking. Unparalleled Quality 11 Published Study Results Alternative Therapies in Health and Medicine published the results of several studies that combined the PMF- source ™ and TocoSource ™, key ingredients found in Cholesstrinol ™. The largest study, a 12-week double blind, placebo-controlled protocol with 120 subjects, resulted in significant improvements in total cholesterol (-30%), LDL (-27%), and triglycerides (-34%).

12 Pure Science. Innovative Thinking. Unparalleled Quality 12 SourceOne Global Partners “Delivering the best science nature has to offer.” - Thank You


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