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What is vitamin D? Vitamin D is classified as a fat soluble vitamin

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Presentation on theme: "What is vitamin D? Vitamin D is classified as a fat soluble vitamin"— Presentation transcript:

1 What is vitamin D? Vitamin D is classified as a fat soluble vitamin
There are two important groups of this compound in humans: Vitamin D3 (Cholecalciferol) Vitamin D2 (Ergocalciferol)

2 Uses of Vitamin D Regulates calcium uptake:
Liver converts cholecalciferol into calcidiol kidney converts calcidiol to calcitriol Transported to intestinal tract, triggering the production of Calcium uptake proteins. Suppresses abnormal cell growth Stimulates immunity and prevents the development of autoimmune diseases. Regulates the release of renin; citing its role in the cardiovascular system

3 Deficiency of vitamin D Prevalence of vitamin D deficiency is 30-50% in the general population. Following disorders are the consequences resulting from this deficiency: Osteoporosis and other bone abnormalities Hip and vertebral fractures Hypertension Congestive heart failure Autoimmune diseases Chronic muscle aches

4 Diagnostic values Serum concentration of 25(OH)D3 are used as diagnostic markers for Vitamin D
Normal levels are ng/ml Concentrations < ng/ml are considered deficient Levels > 60 ng/ml are considered toxic to the body. Recommended daily intake of vitamin D is IU Remember that 100 IU = 1ng/ml

5 Sources of Vitamin D Food source:
Very little food contains adequate amounts of vitamin D. The flesh of certain fatty fish ( salmon, tuna) and cod liver oil is a good source. Small amounts are also found in cheese , beef liver and egg yolks. Sun Exposure: Exposure to sunlight manufactures Vitamin D3 through our skin, that’s why this vitamin is also known as the “sunshine vitamin”. Dietary supplements: Dietary supplements come in both forms of vitamin D. Research has shown D2 to have lesser potency and short duration of action, rendering it half as effective as D3

6 Introducing…D-Sorb™ A wide range of vitamin D-3 potencies using the patented VESIsorb® colloidal droplet technology

7 •Droplets B) 2'000 IU Vit. D*/drop (1drop = 25mg) *as D3 plus Pre-D3
D-Sorb™ in both Liquid Droplets and Solid Dosage Forms •Droplets A) 500 IU Vit. D*/drop (1drop = 25mg) B) 2'000 IU Vit. D*/drop (1drop = 25mg) *as D3 plus Pre-D3 •Available in various potencies from 500IU to 15,000IU of D-3 per capsule and capsule sizes and D-3 potency can be customized

8 Vitamin D Bioavailability & VESIsorb (I)
•Enhanced solubilization of Vitamin D3 by VESIsorb® ...”Body Ready”... Vitamin D3, like Coenzyme Q10, is a poorly water-soluble compound. Thus, enhanced solubilization of Vitamin D3 within the GI fluid by VESIsorb® may improve its oral bioavailability. •Fat/food independent absorption The absorption of Vitamin D3, like the one of other poorly water-soluble vitamins, is dependent on food respectively fat. Like other solubilizing delivery system VESIsorb can reduce this food/fat effects and hence may provide more reproducible Vitamin D3 plasma levels.

9 Vitamin D Bioavailability & VESIsorb (II)
•MCT Vitamin D3 dissolved in medium-chain triglycerides (MCT) produced a 4.25 times greater increase in serum 25(OH)D levels than an ethanol vehicle. Reference: Maalouf et al. J. Clin. Endocrinol. Metab. 93: , 2008 Remember: MCT is a main ingredients of D-Sorb/VESIsorb® •Improved lymphatic absorption Vitamin D3 absorption is associated with lymphatic transport. Reference: Cuiné JF et al. Pharmaceutical Research, 24: , 2007 DSorb/VESIsorb formulation contains ingredients that are known to increase the lymphatic transport capacity

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