2 What are Non-Disjunction Disorders?! Non-disjunction is a failure of chromosomes to separate properly (i.e there is an imbalance of genetic information)Occurs when:Homologous chromosomes fail to separate properly in Anaphase ISister chromatids fail to separate properly during Anaphase IIHaving abnormal amounts of karyotypes will overload the cells, which may result in:The death of the zygoteA person with a non-disjunction disorder being born
3 Key TermsKaryotypesThe number and visual appearance of the chromosomes in the cell nuclei of an organism or speciesTrisomyA condition in which a diploid organism has one more chromosome than usual.47MonosomyAn instance where there is only one chromosome is present, as opposed to the usual two
6 Autosomal Non-Disjunction Refers to chromosome alterations in autosomes one through twenty-two (1 - 22)There only 3 trisomies (13, 18, & 21) that result in a baby that can survive for a time after birthThe other trisomies are so devastating that the baby usually dies in utero
7 WARNING!SOME OF THE PICTURES IN THE FOLLOWING SLIDES MAY BE UPSETTING/TOO GRAPHIC FOR SOME STUDENTS!IF YOU FEEL THE NEED TO, PLEASE LOOK AWAY FROM THE SCREEN
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