1. Assembling a Systematic Review Team: The Duke Experience Gillian D Sanders PhD EPC Director Associate Professor of Medicine Duke Clinical Research Institute Duke University

2. AHRQ Evidence-based Practice Centers (EPCs) n BCBS Technology Evaluation Center (TEC) l Naomi Aronson, PhD n Duke University l Gillian Sanders PhD n ECRI Institute l Karen Schoelles, MD, SM n Johns Hopkins University l Eric B. Bass, MD, MPH n McMaster University l Parminder Raina, PhD n Oregon Health & Science Univ. l Mark Helfand, MD, MPH n RTI International/ UNC l Meera Viswanathan, PhD n Southern California RAND l Paul Shekelle, MD, PhD n Tufts University--NEMC l Joseph Lau, MD n University of Alberta l Terry P. Klassen, MD, MSc l Brian H. Rowe, MD, MSc n University of Connecticut l C. Michael White, PharmD n Minnesota l Robert L. Kane, M.D. l Timothy J. Wilt, MD, MPH n University of Ottawa l David Moher, PhD n Vanderbilt University l Katherine Hartman, MD, PhD

3. Duke EPC Project Portfolio 1. Cardiovascular disease topic identification11. Noninvasive positive pressure ventilation for acute respiratory failure 2. Atrial fibrillation: Treatment12. Diagnosis and management of chronic cough 3. Atrial fibrillation: Stroke prevention13. Pulmonary aterial hypertension 4. Future research needs: ACEIs and ARBs in essential hypertension 14. Methods modules for diagnostic test evaluation 5. Non invasive testing for coronary artery disease in women 15. Oral contraceptive use for the Primary Prevention of Ovarian Cancer 6. Treatment of coronary artery disease in women 16. Screening for postpartum depression 7. Treatment strategies for peripheral artery disease 17. Disease-modifying anti-rheumatic drugs (DMARDS) in children with Juvenile Idiopathic Arthritis 8. Antiplatelet and anticoagulant treatments for unstable angina for UA/NSTEMI 18. Enabling healthcare decision making through clinical decision support and knowledge management 9. Transitions of care for stroke and MI19. Closing the quality gap series: The medical home 10. ECG signal-based analysis20. Treatment of serious mental illness

4. Composition of Project Teams n Staff l Project Leader l Project Coordinator l Editor l Medical Librarian n Investigators (4-8) l EPC Oversight l Principal Investigator l Co-investigators (clinical) l Co-investigators (methodological) l Statistical investigator

5. Other Potential Roles n Key informants n Technical expert panel n Peer reviewer

6. Gillian D Sanders, PhD EPC Director Rowena J Dolor MD, MHS EPC Associate Director Rebecca Gray, DPhil Liz Wing, BS, MA EPC Editors Rachael Posey, MSLS Senior Data Tech Mike Musty, BA Research Analyst Julian Irvine, MCM Research Analyst Amy Kendrick RN, MSN, MS-CRM EPC Manager RhaShawn Wells Business Development Associate Juanita Daniels Financial Analyst Connie Schardt, MLS Megan Von Isenburg, MLS Scientific Librarians Alice Thacher, MBA Research Aide Amanda McBroom, PhD Project Leader II Beverly Perkins, AD Administrative Assistant Project Principal Investigators Project Co-Investigators Karen Pendergast, MPH Project Leader I TBD Research Aide Corey Hadley, MM Statistician Brooke Heidenfelder, PhD Project Leader I Duke University: EPC Organizational Chart

7. Investigators on Current EPC Projects n Cardiology Adrian Hernandez Adrian Hernandez Bimal Shah Bimal Shah Chiara Melloni Chiara Melloni Galen Wagner Galen Wagner Jeffrey Washam Jeffrey Washam Judson Williams Judson Williams Karen Alexander Karen Alexander Manesh Patel Manesh Patel Matthew Brennan Matthew Brennan Monique Anderson Monique Anderson Renato Lopes Renato Lopes Sana Al-Khatib Sana Al-Khatib Sreekanth Vemulapalli Sreekanth Vemulapalli Sumeet Subherwal Sumeet Subherwal William Schuyler William Schuyler Zubin Eapen Zubin Eapen n Pulmonary Bill Hargett Bill Hargett Chris Cox Chris Cox Chris Castillo Chris Castillo Daniel Grilstrap Daniel Grilstrap Joe Govert Joe Govert Njira Ludugo Njira Ludugo n General Internal Medicine Rowena Dolor Rowena Dolor Adia Ross Adia Ross Benjamin Power Benjamin Power David Matchar David Matchar Doug McCrory Doug McCrory George Jackson George Jackson John Williams John Williams Karen Alexander Karen Alexander Kristine Schmidt Kristine Schmidt Lori Bastian Lori Bastian Matt Crowley Matt Crowley Ranee Chatterjee Ranee Chatterjee Will Yancy Will Yancy n Neurology Carmelo Graffignino Carmelo Graffignino Dai Wai Olson Dai Wai Olson n Pediatrics Alex Kemper Alex Kemper Heather VanMater Heather VanMater n Family Medicine David Lobach David Lobach Remy Coeytaux Remy Coeytaux n Nursing Janet Prvu Bettger Janet Prvu Bettger Kathy Wood Kathy Wood n OBGYN/Gyn Oncology Evan Myers Evan Myers Geeta Swamy Geeta Swamy Laura Havrilesky Laura Havrilesky Jeff Lowery Jeff Lowery Rachel Pergallo Rachel Pergallo n Psychiatry Marla Wald Marla Wald Bill Meyers Bill Meyers n Biostatistics/HSR/PharmD Gillian Sanders Gillian Sanders Andrzej Kosinski Andrzej Kosinski Cindy Green Cindy Green Gregory Samsa Gregory Samsa Jennifer Gierisch Jennifer Gierisch Nancy Allen Lapointe Nancy Allen Lapointe Trish Moorman Trish Moorman Vic Hasselblad Vic Hasselblad

8. Managing Conflicts n Make clear up front potential conflicts – financial and intellectual n Delve down in to possible conflicts n Discuss with AHRQ/Task Order Officers n Understand that a conflict on one project doesn’t mean the investigators will be conflicted on all projects n Discuss other potential roles within projects/EPC n Understand incentives for/against participating

9. Building a Team n Use of fellows, housestaff, junior investigators n Building investigator relationships beyond one project n Having high-level staff to ensure positive EPC experience n Development of methodological abilities in general internists n Working with Division Chiefs to identify investigators n Establishing potential of comparative effectiveness research/systematic reviews as area of research focus n Availability of sustained funding (short term/ long term)

10. DISCUSSION/QUESTIONS