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2. 2 2 Ian’s Biography BSc & PhD (Physics) and MBA OCLI - Optical thin films VISION – CMOS imagers Terahertz Photonics – Optical Communications Components Biosensia – Roadside drugs of abuse testing Ambicare – Wearable light sources for skin cancer

3. 3 3 Company Overview Private venture capital backed company Spin-out from St Andrews University and Tayside Health Board Ambulatory lighting technologies for medical and consumer applications ISO 13485 qualified with first product CE marked and launching in Europe

4. 4 4 Medical: Treatment: Ambulight: PDT

5. 5 5 Skin Cancer Skin cancer incidence growing rapidly 15% of UK, 40% of American, 75% of Australian population are affected Ambulight: PDT – Potential to be used in ~ 40% of non-melanoma skin cancer treatments Incidence of skin cancer doubling every ten years USA market data

6. 6 6 Application of ALA* cream at tumour site *5-aminolevulinic acid (5-ALA) Illumination of tumour region with high intensity Light source Presence of light causes PP9 to produce singlet Oxygen leading to local cellular destruction within the tumour only PDT ALA metabolised to Light sensitive Proto porphyrin PP9 only within the tumour Wait 3 hours What is Photodynamic Therapy (PDT)?

7. 7 7 Existing Treatment Techniques Conventional Outpatient PDT – Laser / ILED / bulb based light sources Large and expensive stationary light sources used – Six hours at clinic as a day patient – Costly / nurse intensive – Inconvenient for patient and healthcare provider Treatment can be uncomfortable for patient However, a preferred treatment technique – High tumour selectivity – Curative in 70% + of lesions (after 2 treatments) – Relatively pain free (in ~ 75 % of cases) – Excellent cosmetic result – Non – Invasive – Minimal side effects

8. 8 8 Ambulight: PDT World’s first light emitting sticking plaster to treat non melanoma skin cancer –Low light intensity –Low power consumption allows ambulatory product –Wavelength matched to PDT cream Product CE marked and about to launch in Europe Currently being taken through regulatory approval in the USA, Australia and other countries Significant benefits over competing products and methods Potential to transform patient care by enabling “normal life” during treatment

9. 9 9 Ambulight: PDT Device applied at same time as PDT cream Device worn during normal daily activities Device disposed Typical Device Treatment Cycle

10. 10 Ambulight PDT: Pilot Clinical Trial Shows equivalence to existing PDT treatment methods > 70% clearance rate using 1/10 th the intensity for 10 times as long Reduced pain Patient testimonials PatientDiagnosis Lesion size (cm) 1st Rx2nd RxOutcome at 6 months 1Bowens 1.1 Oct '05Nov '05Clear 2Bowens 1.1 Oct '05Nov '05Fail peripheral margin 3SBCC 1.7 Nov '05Dec '05Clear 4Bowens 1.2 Nov '05Dec '05Clear 5SBCC 1.6 Feb '06March '06Clear 6Bowens 0.7 Feb '06March '06Clear 7SBCC 1.5 Feb '06March '06Clear 8Bowens 1.7 Feb '06April '06Fail peripheral margins 9Bowens 1.0 Feb '06April '06Clear 10Bowens 0.6 March '06April '06Clear 11SBCC 1.9 March '06April '06Fail peripheral margins 12Bowens 1.1 April '06June '06Clear

11. 11 Ambulight: PDT Benefits to healthcare providers Changes the way in which doctors can treat skin cancer – Home – Family doctor Simple and easy to use Potentially frees up hospital beds Less costly High patient throughput Benefits to Patients More comfortable treatment Equivalence or improved treatment success rate Reduced scarring Transition bulky light sources to small and portable

12. 12 Economics of treatment Patient Journey GP consultation ( x 1 or more) Dermatologist consultation ( x 3 or more) Transport to and from hospital Local anaesthetic (if pain experienced) Hospital cubicle / day patient bed space Nurse time Other overhead e.g. Health and safety on laser equipment, eye protection goggles, air coolers for skin PDT cream cost Ambulight PDT light source* * cost of items highlighted in red can be removed or greatly reduced by introduction of Ambulight PDT light source over conventional light source

13. 13 How do you build a university technology spin-out?

14. 14 Migrating Researchers into Entrepreneurs and into Start-Up companies IP filing and commercial assessment Deciding what you want from it Recognise your strength and weaknesses and build a team Never be afraid to ask for advice but seek it from multiple sources Do your home work and write a good business plan (through collaboration if necessary). Plan your fund raising Be prepared for the highs, lows and unknowns.... And hope for a bit of luck on the way Why do I love it.... You will never have two days the same

15. 15 What’s the challenges of interdisciplinary teams?

16. 16 What’s the challenges of interdisciplinary teams (in healthcare)? You have more views to accommodate and manage If more people have been involved in the invention then more people looking for a share of the equity (individuals and institutions) – Can take longer to reach agreement on licence contracts or company set up You may have more technology monitoring to do to remain competitive in your market place In healthcare the time from patent filing to establishing validity of concept in patients can be quite long – Increased cost – Takes longer to establish value; this impacts how you raise finance

17. 17 info@ambicarehealth.com info@ambicarehealth.com Thank you for your attention