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Agenda 01 About Pollogen – Expect more 02 geneO+ Revolutionary skin care platform 03 OxyGeneo™ & TriPollar® – Technologies Overview 04 Clinical results.

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Presentation on theme: "Agenda 01 About Pollogen – Expect more 02 geneO+ Revolutionary skin care platform 03 OxyGeneo™ & TriPollar® – Technologies Overview 04 Clinical results."— Presentation transcript:

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2 Agenda 01 About Pollogen – Expect more 02 geneO+ Revolutionary skin care platform 03 OxyGeneo™ & TriPollar® – Technologies Overview 04 Clinical results and B&A

3 01 About Pollogen Expect more

4 As technology leaders, we continuously challenge ourselves to deliver innovation with genuine added value for aesthetic professionals. Pollogen develops & markets advanced solutions for the aesthetics market

5 Pollogen - Expect more We believe that every customer deserves to benefit from the best of all worlds: safe, pleasant and non- invasive treatment, as well as long-lasting results that can be seen and felt immediately To contend with this challenge, we develop innovative technologies, manufacture smart & user-friendly systems and offer a broad variety of treatments with proven results. Above all, we redefine the standards in the world of aesthetics and are committed at all times to give you more…

6 More Global presence Over 60 distributors worldwide

7 More Results Clinically proven Peer reviewed papers in leading medical journals confirming the safety and effectiveness of Pollogen’s technologies.

8 More Partnership With Pollogen, you have a true partner Pollogen will accompany you the whole way and provide you with a comprehensive range of services of exceptional standard: Updates on new technological developments Product training Clinical support Technical support Supply of marketing materials Direct communication with the sales manager Comprehensive marketing consulting and support

9 From small niche to a $4.4B market In the past decade, the global aesthetics market has grown at a double-digit pace, developing from a small niche to a $3.3B market in Despite the global recession, consumers continue to invest in beauty treatments, & the market is expected to reach $4.4B in More Opportunities Source: BCC Research

10 More Innovations Pollogen® is a world leader in innovative, clinically proven, aesthetic solutions for facial treatments and body sculpting.

11 More Leadership Mr. Moshe Shneor, C.P.A., CFO and COO. Mr. Shneor was a senior executive at Ernst & Young where he was responsible for global standardization of Israeli companies on NASDAQ. Dr. Zion Azar, PhD, Founder and Chairman of the Board. Founded Radiancy & PolyOptics. Dr. Azar has a PhD in physics from Tel-Aviv University. Mr. Amichai Bar-Nir, CEO. Mr. Bar-Nir has proven management experience in leading companies through rapid growth and new market penetration. In the past he managed hi-tech companies such as Cognifit and Bi-Plan. The management team includes VP’s with over 100 years of cumulative experience in the field, including clinical studies, sales, regulations, R&D and marketing.

12 Revolutionary skin care platform 02

13 Introducing… Where superior aesthetic treatments meet RF technology to create a breakthrough skin-care platform

14 Designed with the aesthetic professional in mind, geneO+ integrates Pollogen’s new patented OxyGeneo technology with renowned TriPollar technology. geneO+ delivers superior skin nourishment and oxygenation together with clinically proven anti-aging results. Product Overview The combination of TriPollar RF and OxyGeneo improves skin quality both at the epidermis and dermis layers delivering long lasting results

15 Business benefits for clinics New treatment options and increased customer flow Position your clinic as a leader and gain an advantage over your competitors with cutting-edge technology and design Increased income & quick ROI Affordable product entry price Charge premium price for treatments Increase repeat customers and customer loyalty geneO+ treatments are an ideal opportunity to upsell home use cosmetics/treatments Join the success! Be one of the thousands of clinics worldwide that offer patented TriPollar & OxyGeneo Technologies!

16 OxyGeneo™ and TriPollar® combination protocol

17 Advantages of OxyGeneo & TriPollar OxyGeneo - A 3 in 1 skin care treatment to actively nourish, vitalize and hydrate the skin: Exfoliation of the outer skin layer Infusion of revitalizing nutrients Oxygenation of skin generated from within TriPollar RF – The 3 rd generation RF anti-aging technology Wrinkle reduction Skin tightening Safe, effective and pleasant Immediate and long term results

18 Protocol according to indication Treatment focused on fine lines and wrinkles - 6 weekly sessions, followed by monthly touch up session. First OxyGeneo (NeoRevive or NeoBright ~8 min) and then TriPollar (full face ~30 min) The OxyGeneo treatment exfoliates the stratum corneum and enables better impact of the RF Treatment focused on improving skin texture and nourishment 6 weekly sessions, followed by monthly touch up session First TriPollar (full face ~20 min) and then OxyGeneo (NeoRevive or NeoBright ~8 min) The RF treatment increases blood circulation and improves penetration of the active ingredients of the gel. Note: both protocols can be finalized with NeoMassage session (~5 min)

19 OxyGeneo & TriPollar Technologies Overview 03

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21 OxyGeneo Technology Similar to the natural hot springs effect, OxyGeneo™ is the world’s first technology that significantly accelerates the absorption and optimal utilization of nutrients by the skin using our exclusive Capsugen and specialized Gels. Natural hot springs have been known through the ages for their therapeutic benefits, allowing minerals to be effectively absorbed through the skin to revitalize body cells.

22 Harnesses the body's natural mechanisms to deliver 3 effective treatments simultaneously: Exfoliation of the outer skin layer Infusion of revitalizing nutrients with Pollogen’s unique skin care formulas Natural skin Oxygenation from within OxyGeneo’s “3 in 1” approach creates an optimal environment for the skin to absorb essential nutrients both during and after treatment. OxyGeneo uses disposable and easy to sterilize components that ensures maximum hygiene during every treatment. OxyGeneo Technology Each treatment includes a unique combination of Capsugen™ and gels developed by Pollogen from natural ingredients

23 OxyGeneo - How it works Pollogen’s unique Capsugen™ is composed of sodium bi-carbonate and citric acid. Our exclusive gel contains natural active ingredients. When the effervescent Capsugen™ comes in contact with the exclusive treatment gel on the skin surface an immediate reaction is triggered. This reaction induces the OxyGeneo effect that simultaneously: Exfoliates the skin’s outer layer Prepares it for infusion of active ingredients Infuses the natural active ingredients deep into the epidermis Enriches the area with O 2 rich blood

24 OxyGeneo - How it works OxyGeneo produces countless minute CO 2 bubbles which gently burst on the skin surface. The OxyGeneo applicator is designed to degas the CO 2 bubbles from the gel and infuse them into the epidermis. The applicator’s frequency and amplitudes are specifically designed to: Produce a kinetic force that optimizes the chemical reaction generating CO 2 bubbles and: Enable optimal penetration of CO 2 bubbles into the epidermis.

25 OxyGeneo - How it works The outcome is a CO 2 rich environment on the skin's surface*. The body responds by: Sending O 2 rich blood to the area Increasing capillary blood flow Increasing metabolism of the skin cells The desired result: Optimal absorption of the active ingredients by the skin * The chemical reaction between the Capsugen and the gel that generates CO 2 :

26 OxyGeneo and The Bohr Effect C0 2 rich environment & infusion of active ingredients Oxygenation of skin cells & skin rejuvenation This C0 2 rich environment induces a physiological response called the BOHR EFFECT leading to increased tissue oxygen.

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28 TriPollar 3 rd generation RF technology: TriPollar utilizes RF energy to induce collagen & elastin regeneration in the dermis layer. Leading to: Smoother and tighter skin Fine lines and wrinkles reduction Improved skin texture TriPollar® Technology

29 3 rd generation TriPollar RF - applies conductive RF to the skin via 3 or more electrodes Energy is focused in the target area for optimal effect – not requires cooling Volumetric heating generates clinical effect The most pleasant RF treatment due to focused energy field allowing low power consumption Pollogen’s Breakthrough TriPollar Technology

30 TriPollar® Preparation Gel The matching fluid for the TriPollar treatment is the TriPollar Preparation Gel. The TriPollar preparation gel should be applied on the treatment area before starting the TriPollar RF treatment. The gel lubricates the area and allows smooth movement of the applicator on the skin. Has a high electrical resistance forcing the electrical current to enter deep into the skin, avoiding the current from flowing on the surface and creating sparks

31 TechImageClinical targetPowerPain Level CoolingVisible Clinical Results Mono PolarCollagen fibers High ( W) Might be Very Painful AlwaysAfter months Uni Polar (RF radiation) Collagen fibers High ( W) Very hotAlwaysAfter months Bi – PolarDermis & hypodermis Medium ( W) May be Painful May beAfter days / weeks TriPollar ® Focused energy on dermis & hypodermis Low (5 – 50W) No Pain Pleasant NoneImmediate & long term. supported by clinical and histopathological studies Comparison of TriPollar® to other RF technologies

32 Clinical Results and B&A 04

33 Clinical studies and B&A

34 EVALUATION OF SAFETY AND EFFICACY OF THE TRIPOLLAR® TECHNOLOGY FOR TREATMENT OF WRINKLES Steven D. Shapiro MD & Amos Leviav MD Study Objective: To evaluate the safety of the apollo™ system for treatment of wrinkles and rhytides. To evaluate the efficacy of the apollo™ system for treatment of wrinkles and rhytides. Methods: Subjects: 37 Female subjects were recruited - 37 completed all treatments, 3 lost to follow- up due to travel or change of residence. Visits: 8 Weekly treatments, Follow-Up at 1 month and 3 months after treatment 8. Two sites: ―Steven Shapiro MD (Dermatologisit) – Gardens Dermatology and Cosmetic Surgery Center, Florida US ―Amos Leviav MD (Plastic Surgeon) - Kaplan Hospital, Israel STUDY # 1

35 Results Safety ―No unexpected adverse side effects were detected or reported. ―All subjects reported no pain or mild pain during the treatments. Efficacy ―A downgrade of at least 1 score in Fitzpatrick scale was found in 94% (1st reviewer) and 97% (2nd reviewer) of study subjects. ―Subjects satisfaction questionnaires revealed high level of satisfaction. ―PI’s scoring of subjects’ facial skin appearance at baseline and 3 at month FU demonstrated average reduction of 1.55 (Dr. Leviav) and 2.4 (Dr. Shapiro). Conclusions The results of this study clearly indicate that the TriPollar technology offers a non-invasive, effective, safe and virtually painless wrinkle and rhytides reduction treatment. STUDY # 1

36 Sample photos: A 51 years old female Before - Baseline After - 3M following 8 Tx STUDY # 1

37 Sample photos: A 42 years old female Before- Baseline After - 3M following 8 Tx STUDY # 1

38 Sample photos: A 59 years old female Before- Baseline After - 3M following 8 Tx STUDY # 1

39 Sample results: A 61 years old female Before- Baseline After - 3M following 8 Tx STUDY # 1

40 CLINICAL EXPIRIENCE WITH A TRIPOLLAR® RADIOFREQUENCY SYSTEM FOR FACIAL AND BODY AESTHETIC TREATMENTS Dr. Alex Levenberg Study Objective: To evaluate the safety and efficacy of the TriPollar® for non-invasive treatment of localized excess fat and facial tightening Materials and Methods: 37 female patients Average of 7 treatments for wrinkles, laxity and circumference reduction on different facial and body areas. Evaluation methods: o Facial results objectively analyzed with Primos 3D imaging system o Photographs – evaluate facial results STUDY # 2

41 Results: Average circumference reduction, in main body areas (abdomen, buttocks, thighs): 3.6 ± 2.4 cm (P < ) Abdomen: 4.5 ± 2.7 cm, max 10.5 cm Buttocks: 3.1 ± 1.7 cm, max 5 cm Thighs: 2.4 ± 2.0 cm, max 6.4 cm Improvement of perioral and periorbital wrinkles was achieved Before After 8 Tx STUDY # 2

42 Clinical studies and B&A

43 OxyGeneo™ TECHNOLOGY CLINICAL STUDY Study Objective To understand the OxyGeneo™ mechanism by evaluating its effects on blood perfusion, tissue CO 2 and O 2 levels and the thermal effect of the treatment. Study method Blood perfusion, tissue CO 2 and O 2 levels and thermal imaging profiles were measured on different body areas of 11 subjects. Base line control measurements were taken before treatment. Treatment was performed for ~10 minutes. Study was performed by an independent 3 rd party: Physiological Models STUDY # 1

44 OxyGeneo™ TECHNOLOGY CLINICAL EFFECT CO 2 and O 2 levels as measured before and after treatment: CO 2 levels (in blue) returned to baseline values while the O 2 (in green) levels rose above the baseline levels 15 min after treatment. STUDY # 1

45 Increase in blood perfusion immediately after the treatment and a gradual return to base line levels. 15 min after treatment the values were higher than the baseline. These parameters demonstrate an increase in flow and intensity OxyGeneo™ TECHNOLOGY CLINICAL EFFECT STUDY # 1

46 Study method 20 female volunteers, ages were included in the study. 6 weekly facial treatments were conducted. Treatment was performed for ~10 minutes. The procedure was performed by a beautician and supervised by a dermatologist. The following assessments were included: o Auto evaluation (questionnaires to volunteers) Evaluation Scale: 1.Repulsive 2.Not satisfactory 3.Acceptable 4.Good 5.Excellent o Evaluation by professional expert (dermatologist) o B&A photographs OxyGeneo™ TECHNOLOGY– NEOREVIVE CLINICAL STUDY STUDY # 2

47 NeoRevive® Results STUDY # 2

48 before after Enhancement of skin's pebbled appearance (elastosis). The diffuse netted pigmentation of the encircled area has almost cleared. The region looks more uniform and shiny. NeoRevive® Results STUDY # 2

49 More B&A

50 Courtesy of Dr. Stavros Eleftheriou, Surgical Art Clinic, Larnaca, Cyprus Treated side Non-treated side Facial Skin Tightening after 1 treatment TriPollar Technology - Immediate Results 50

51 Facial Skin Tightening after 5 treatments Pollogen in house collection – Tel Aviv, Israel TriPollar Technology - Long Term Results 51 beforeafter

52 OxyGeneo treatment results Fine lines improvement Immediately after 1 NeoRevive treatment after before GFM PRIMOS portable 3D measuring system version 5.6 Same client as on previous slide

53 OxyGeneo treatment results Skin smoothness demonstrated by (x500 ) Microscope Immediately after 1 NeoRevive treatment before after

54 THANK YOU SYDNEY AUSTRALIA


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