2. Agenda
01 About Pollogen – Expect more 02 geneO+ Revolutionary skin care platform 03 OxyGeneo™ & TriPollar® – Technologies Overview 04 Clinical results and B&A

3. 01
About Pollogen Expect more

4. Pollogen develops & markets advanced solutions for the aesthetics market
As technology leaders, we continuously challenge ourselves
to deliver innovation with
genuine added value for
aesthetic professionals.

5. We believe that every customer deserves to benefit from the best of all worlds: safe, pleasant and non-invasive treatment, as well as long-lasting results that can be seen and felt immediately
To contend with this challenge, we develop innovative technologies, manufacture smart & user-friendly systems and offer a broad variety of treatments with proven results.
Above all, we redefine the standards in the world of aesthetics and are committed at all times to give you more…
Pollogen - Expect more

6. Over 60 distributors worldwide
More Global presence
Over 60 distributors worldwide

7. More Results
Clinically proven Peer reviewed papers in leading medical journals confirming the safety and effectiveness of Pollogen’s technologies.

8. More Partnership
With Pollogen, you have a true partner Pollogen will accompany you the whole way and provide you with a comprehensive range of services of exceptional standard:
Updates on new technological developments
Product training
Clinical support
Technical support
Supply of marketing materials
Direct communication with the sales manager
Comprehensive marketing consulting and support

9. From small niche to a $4.4B market
More Opportunities
From small niche to a $4.4B market
In the past decade, the global aesthetics market has grown at a double-digit pace, developing from a small niche to a $3.3B market in 2010.
Despite the global recession, consumers continue to invest in beauty treatments, & the market is expected to reach $4.4B in 2015.
Source: BCC Research

10. More Innovations
Pollogen® is a world leader in innovative, clinically proven, aesthetic solutions for facial treatments and body sculpting.

11. More Leadership
Dr. Zion Azar, PhD, Founder and Chairman of the Board. Founded Radiancy & PolyOptics. Dr. Azar has a PhD in physics from Tel-Aviv University.
Mr. Amichai Bar-Nir, CEO. Mr. Bar-Nir has proven management experience in leading companies through rapid growth and new market penetration. In the past he managed hi-tech companies such as Cognifit and Bi-Plan.
Mr. Moshe Shneor, C.P.A., CFO and COO. Mr. Shneor was a senior executive at Ernst & Young where he was responsible for global standardization of Israeli companies on NASDAQ.
The management team includes VP’s with over 100 years of cumulative experience in the field, including clinical studies, sales, regulations, R&D and marketing.

12. 02
Revolutionary skin care platform

13. Introducing… Where superior aesthetic treatments meet RF technology
to create a breakthrough skin-care platform

14. Product Overview
Designed with the aesthetic professional in mind, geneO+ integrates Pollogen’s new patented OxyGeneo technology with renowned TriPollar technology.
geneO+ delivers superior skin nourishment and oxygenation together with clinically proven anti-aging results.
The combination of TriPollar RF and OxyGeneo improves skin quality both at the epidermis and dermis layers delivering long lasting results

15. Business benefits for clinics
New treatment options and increased customer flow
Position your clinic as a leader and gain an advantage over your competitors with cutting-edge technology and design
Increased income & quick ROI
Affordable product entry price
Charge premium price for treatments
Increase repeat customers and customer loyalty
geneO+ treatments are an ideal opportunity to upsell home use cosmetics/treatments
Join the success! Be one of the thousands of clinics worldwide that offer patented TriPollar & OxyGeneo Technologies!

16. OxyGeneo™ and TriPollar® combination protocol

17. Advantages of OxyGeneo & TriPollar
OxyGeneo - A 3 in 1 skin care treatment to actively nourish, vitalize and hydrate the skin:
  Exfoliation of the outer skin layer
  Infusion of revitalizing nutrients
  Oxygenation of skin generated from within
TriPollar RF – The 3rd generation RF anti-aging technology
Wrinkle reduction
Skin tightening
Safe, effective and pleasant
Immediate and long term results

18. Protocol according to indication
Treatment focused on fine lines and wrinkles  -
6 weekly sessions, followed by monthly touch up session.
First OxyGeneo  (NeoRevive or NeoBright ~8 min) and then TriPollar  (full face ~30 min)
The OxyGeneo treatment exfoliates the stratum corneum and enables better impact of the RF
Treatment focused on improving skin texture and nourishment
6  weekly sessions, followed by monthly touch up session
First TriPollar (full face ~20 min) and then OxyGeneo  (NeoRevive or NeoBright ~8 min)
The RF treatment increases blood circulation and improves penetration of the active ingredients of the gel.
Note: both protocols can be finalized with NeoMassage session (~5 min)

19. 03
OxyGeneo & TriPollar
Technologies Overview

21. OxyGeneo Technology
Natural hot springs have been known through the ages for their therapeutic benefits, allowing minerals to be effectively absorbed through the skin to revitalize body cells.
Similar to the natural hot springs effect, OxyGeneo™ is the world’s first technology that significantly accelerates the absorption and optimal utilization of nutrients by the skin using our exclusive Capsugen and specialized Gels.

22. OxyGeneo Technology
Harnesses the body's natural mechanisms to deliver 3 effective treatments simultaneously:
Exfoliation of the outer skin layer
Infusion of revitalizing nutrients with Pollogen’s unique skin care formulas
Natural skin Oxygenation from within
OxyGeneo’s “3 in 1” approach creates an optimal environment for the skin to absorb essential nutrients both during and after treatment.
OxyGeneo uses disposable and easy to sterilize components that ensures maximum hygiene during every treatment.
Each treatment includes a unique combination of Capsugen™ and gels developed by Pollogen from natural ingredients

23. OxyGeneo - How it works
Pollogen’s unique Capsugen™ is composed of sodium bi-carbonate and citric acid. Our exclusive gel contains natural active ingredients.
When the effervescent Capsugen™ comes in contact with the exclusive treatment gel on the skin surface an immediate reaction is triggered.
This reaction induces the OxyGeneo effect that simultaneously:
Exfoliates the skin’s outer layer
Prepares it for infusion of active ingredients
Infuses the natural active ingredients deep into the epidermis
Enriches the area with O2 rich blood

24. OxyGeneo - How it works
OxyGeneo produces countless minute CO2 bubbles which gently burst on the skin surface.
The OxyGeneo applicator is designed to degas the CO2 bubbles from the gel and infuse them into the epidermis.
The applicator’s frequency and amplitudes are specifically designed to:
Produce a kinetic force that optimizes the chemical reaction generating CO2 bubbles and:
Enable optimal penetration of CO2 bubbles into the epidermis.

25. OxyGeneo - How it works
The outcome is a CO2 rich environment on the skin's surface*.
The body responds by:
Sending O2 rich blood to the area
Increasing capillary blood flow
Increasing metabolism of the skin cells
The desired result: Optimal absorption of the active ingredients by the skin
* The chemical reaction between the Capsugen and the gel that generates CO2:

26. OxyGeneo and The Bohr Effect
C02 rich environment & infusion of
active ingredients
Oxygenation of skin cells &
skin rejuvenation
This C02 rich environment induces a physiological response called the BOHR EFFECT leading to increased tissue oxygen.

28. TriPollar® Technology
TriPollar 3rd generation RF technology:
TriPollar utilizes RF energy to induce collagen & elastin regeneration in the dermis layer. Leading to:
Smoother and tighter skin
Fine lines and wrinkles reduction
Improved skin texture

29. Pollogen’s Breakthrough TriPollar Technology
3rd generation TriPollar RF - applies conductive RF to the skin via 3 or more electrodes
Energy is focused in the target area for optimal effect – not requires cooling
Volumetric heating generates clinical effect
The most pleasant RF treatment due to focused energy field allowing  low power consumption

30. TriPollar® Preparation Gel
The matching fluid for the TriPollar treatment is the TriPollar Preparation Gel.
The TriPollar preparation gel should be applied on the treatment area before starting the TriPollar RF treatment.
The gel lubricates the area and allows smooth movement of the applicator on the skin.
Has a high electrical resistance forcing the electrical current to enter deep into the skin, avoiding the current from flowing on the surface and creating sparks

31. Comparison of TriPollar® to other RF technologies
Image
Clinical target
Power
Pain Level
Cooling
Visible Clinical Results
Mono Polar
Collagen fibers
High
( W)
Might be Very Painful
Always
After months
Uni Polar
(RF radiation)
Very hot
Bi – Polar
Dermis & hypodermis
Medium
(10-200W)
May be Painful
May be
After days / weeks
TriPollar®
Focused energy on dermis & hypodermis
Low
(5 – 50W)
No Pain Pleasant
None
Immediate & long term. supported by clinical and histopathological studies

32. 04
Clinical Results and B&A

33. Clinical studies and B&A

34. EVALUATION OF SAFETY AND EFFICACY OF THE TRIPOLLAR® TECHNOLOGY FOR TREATMENT OF WRINKLES
Steven D. Shapiro MD & Amos Leviav MD
Study Objective:
To evaluate the safety of the apollo™ system for treatment of wrinkles and rhytides.
To evaluate the efficacy of the apollo™ system for treatment of wrinkles and rhytides.
Methods:
Subjects: 37 Female subjects were recruited - 37 completed all treatments, 3 lost to follow-up due to travel or change of residence.
Visits: 8 Weekly treatments, Follow-Up at 1 month and 3 months after treatment 8.
Two sites:
Steven Shapiro MD (Dermatologisit) – Gardens Dermatology and Cosmetic Surgery Center, Florida US
Amos Leviav MD (Plastic Surgeon) - Kaplan Hospital, Israel
STUDY # 1

35. Results
Safety 
No unexpected adverse side effects were detected or reported.
All subjects reported no pain or mild pain during the treatments.
Efficacy
A downgrade of at least 1 score in Fitzpatrick scale was found in 94% (1st reviewer) and 97% (2nd reviewer) of study subjects.
Subjects satisfaction questionnaires revealed high level of satisfaction.
PI’s scoring of subjects’ facial skin appearance at baseline and 3 at month FU demonstrated average reduction of 1.55 (Dr. Leviav) and 2.4 (Dr. Shapiro) .
Conclusions
The results of this study clearly indicate that the TriPollar technology offers a non-invasive, effective, safe and virtually painless wrinkle and rhytides reduction treatment.
STUDY # 1

36. Sample photos: A 51 years old female
Before - Baseline
After - 3M following 8 Tx
STUDY # 1

37. Sample photos: A 42 years old female
Before- Baseline
After - 3M following 8 Tx
STUDY # 1

38. Sample photos: A 59 years old female
Before- Baseline
After - 3M following 8 Tx
STUDY # 1

39. Sample results: A 61 years old female
Before- Baseline
After - 3M following 8 Tx
STUDY # 1

40. CLINICAL EXPIRIENCE WITH A TRIPOLLAR® RADIOFREQUENCY SYSTEM FOR FACIAL AND BODY AESTHETIC TREATMENTS Dr. Alex Levenberg
Study Objective:
To evaluate the safety and efficacy of the TriPollar® for non-invasive treatment of localized excess fat and facial tightening
Materials and Methods:
37 female patients
Average of 7 treatments for wrinkles, laxity and circumference reduction on different facial and body areas.
Evaluation methods:
Facial results objectively analyzed with Primos 3D imaging system
Photographs – evaluate facial results
STUDY # 2

41. Results:
Average circumference reduction, in main body areas (abdomen, buttocks, thighs): 3.6 ± 2.4 cm (P < )
Abdomen: 4.5 ± 2.7 cm, max 10.5 cm
Buttocks: 3.1 ± 1.7 cm, max 5 cm
Thighs: 2.4 ± 2.0 cm, max 6.4 cm
Improvement of perioral and periorbital wrinkles was achieved
Before After 8 Tx
STUDY # 2

42. Clinical studies and B&A

43. OxyGeneo™ TECHNOLOGY CLINICAL STUDY
Study was performed by an independent 3rd party: Physiological Models
Study Objective
To understand the OxyGeneo™ mechanism by evaluating its effects on blood perfusion, tissue CO2 and O2 levels and the thermal effect of the treatment.
Study method
Blood perfusion, tissue CO2 and O2 levels and thermal imaging profiles were measured on different body areas of 11 subjects.
Base line control measurements were taken before treatment.
Treatment was performed for ~10 minutes.
STUDY # 1

44. OxyGeneo™ TECHNOLOGY CLINICAL EFFECT
CO2 and O2 levels as measured before and after treatment:
CO2 levels (in blue) returned to baseline values while the O2 (in green) levels rose above the baseline levels 15 min after treatment.
STUDY # 1

45. OxyGeneo™ TECHNOLOGY CLINICAL EFFECT
Increase in blood perfusion immediately after the treatment and a gradual return to base line levels.
15 min after treatment the values were higher than the baseline.
These parameters demonstrate an increase in flow and intensity
STUDY # 1

46. OxyGeneo™ TECHNOLOGY– NEOREVIVE CLINICAL STUDY
Study method
20 female volunteers, ages were included in the study.
6 weekly facial treatments were conducted.
Treatment was performed for ~10 minutes.
The procedure was performed by a beautician and supervised by a dermatologist.
The following assessments were included:
Auto evaluation (questionnaires to volunteers)
Evaluation Scale:
Repulsive
Not satisfactory
Acceptable
Good
Excellent
Evaluation by professional expert (dermatologist)
B&A photographs
STUDY # 2

47. NeoRevive® Results
STUDY # 2

48. NeoRevive® Results after before
Enhancement of skin's pebbled appearance (elastosis).
The diffuse netted pigmentation of the encircled area has almost cleared.
The region looks more uniform and shiny.
STUDY # 2

49. More B&A

50. TriPollar Technology - Immediate Results
Facial Skin Tightening after 1 treatment
Non-treated side
Treated side
Courtesy of Dr. Stavros Eleftheriou, Surgical Art Clinic, Larnaca, Cyprus

51. TriPollar Technology - Long Term Results
Facial Skin Tightening after 5 treatments
before
after
Pollogen in house collection – Tel Aviv, Israel

52. OxyGeneo treatment results
Fine lines improvement Immediately after 1 NeoRevive treatment
before
after
GFM PRIMOS portable 3D measuring system  version 5.6
Same client as on previous slide

53. OxyGeneo treatment results
Skin smoothness demonstrated by (x500 ) Microscope Immediately after 1 NeoRevive treatment
before
after

54. THANK YOU SYDNEY AUSTRALIA www.karpati.com.au +61 2 9009 6666