Presentation on theme: "Gibbs sampling Morten Nielsen, CBS, BioSys, DTU. Class II MHC binding MHC class II binds peptides in the class II antigen presentation pathway Binds peptides."— Presentation transcript:
Use of Gibbs sampling More than 1,000 papers in PubMed using Gibbs sampling methods Transcription start-sites Receptor binding sites Acceptor:Donor sites...
Summary Weight matrices can accurately describe a sequence motif like MHC class I Use sequence weighting to remove data redundancy Use pseudo count to compensate for few data points Gibbs sampling can detect MHC class II binding motif