1. MAMMAry gland By : Erma Safitri, M.Si., Drh. Faculty of Veterinary Medcine Airlangga University Surabaya

2. ANATOMY OF MAMMARY GLAND Modificated : Skin Gland + Nepple + Water Milk Homologue : Sweat Gland Based of Location : 1.Inguinale : Cow, Ewe, Goat, Buffalo, Mare 2. Pectoralis : Elephant & Primate 3. Abdominalis : Sow, Dog, Cat

3. Mammary Gland : Σ, Form, Measurrement & Located : Different Base Structure : Same Consist of : 1.Sekretion Tissue/Parenchima: Epithel Sekretion Cell (ALVEOLI) 2. Binding Tissue (STROMA)

4. In 1 Kuartir consist of 1 Teat Sisterna & 1 Streak Canal (Teat Meatus)

5. In 1 Kuartir consist 2 Teat Sisterna & 2 streak canal

6. In 1 Kuartir consist of Many Teat Sisterna & Many Streak Canal

7. Milk Product ↗ Average Milk Product Milk Product ↓

8. With TRUNK For suckling With Mouth For suckling Process Pencarian Putting Susu With Botle milk

11. Adhesion of Mammary Gland by : 1. Skin 2. Lig. Suspensorium medialis : Yellow, Elastis Tissue, Lamellae Formed/ Lempengan 3. Lig suspensorium lateralis: Fibrous Tissue, Terminate on Tendon from os Ischium & Pubis ALVEOLI : like Grappes Fruit Like Lung Tissue Diameter : 0,1 – 0,3 mm Consist : Stratum of Epitel Secretori Cell Function : (Side of Produce/ Milk Syntesis) 1.Take of Nutrient from Blood 2. Change of nutrient from Blood 3. Flow of Nutrient to the Lumen

13. Each of Kuartir separated in : Blood Suplai, Nervous Suplai & Ligamentum (Lateralis & Medialis)

14. Each of Mammary separated in : 1.Suplai Darah 2. Suplai Syaraf 3. Aparatus Suspensorius: Lig. Susp. Lat & Med SIRKULATION 1. PUDICUM EXTERNA Artery MAMMARICA EXTERNA Artery CAPILER System in the ALVEOLUS 2. VENA : Anastomose - 2 track = CAVA Vein PUDICUM EXTERNA Vein SUBCUTANEUS ABDOMINALIS Vein (Milk Vein)

17. INERVATION/ STIMULATION : 1. HORMONE MECHANISME 2. NEURAL MECHANISME : A. AUTONOMIC : INTERNAL (Induk) B. SOMATIS : EKSTERNAL (Suckling, Habitualis)

19. PROCCES OF MILK SYNTESIS

21. PROLIFERATION & FUNCTION OF MAMMARY GLAND: 1.MAMMOGENESIS Proliferation of Mammary Gland to indicated with Proliferation of Cell 2. LACTOGENESIS Sintesys to Produce/ Milk Sekretion 3. GALACTOPOIESIS Maintenance of Milk Suplai (Laktation) 4. MILK EJECTION Milk go out in large number from ALVEOLI Ejection from Mammary Gland b/ Suckling

22. 1. MAMMOGENESIS : Proliferation control of Mammary Gland E2 : Proliferation of Ductus system (in Every Estrous & Pregnant) P4 : Proliferation of Mammary Alveolar HORMONE MECHANISME HIPOTALAMUS GH PRL HIPOFISA ANTERIOR DUCTUS OVARIUM ALVEOLI E2 P4PLACENTA LACTOGEN

23. PLASENTAL LACTOGEN = SOMATOMAMMOTROPHINE Structure & Biology Aktivity Like GH & PRL Produced by Placenta 2. LACTOGENESIS : At GRAVID Phase: E2 + P4 ↗↗ PRL ↙ Stopped At PARTUS/ OVARIECTOMY/ INVOLUTIO CL Become MECHANISME : PARTUS P4 ↙↙↙ & E2 ↙ HIPOFISA ANTERIOR PROLAKTIN MILK SECRETION

24. 3. GALACTOPOIESIS : Hipofisa Gland : Important for Laktation maintenance PRL : shock for milk secretion HORMONES THE ROLE OF GLAND PROLIFERATION FSH LH LTH/ PRL ACTH TSH E2 P4 PLASENTA LACTOGEN

25. SUCKLING IMPULS SYARAF N. PARAVENTR. HIPOTHALAMUS OXITOCYN HIPOFISA POST. BLOOD VESSEL CONTRACTION OF MYOEPITHEL CELLS MILK EJECTION Trac. Hipothalamico- Hipofiseal

26. LAKTASI TDD 2 FASE: SEKRESI & PELEPASAN AS MEKANISME SEKRESI: HIPOFISA ANTERIOR FSH & LH OVARIUM PERTUMB. DUCT P4 ↗↗ E2 ↗ PERTUMB. ALVEOLI PARTUS E2 ↙, P4 ↙ & Suckling H.A. LTH INISIASI LAKTASI

27. 1. There isn’t Suckling 2. Disturb of Milk Ejection : Worry, Afraid, Bashful, Sad & High Emotion 3. Tx/ EPINEPPRIN: Stimulate inhibiting of nervous to Neurohypofisis so that didn’t out of oxytocin 4. Cutting of Pituitary stalk 5. Demaging of Hipothalamus region

28. STOPPED LAKTATION RATHER QUICKLY If Mammary Gland full filled b/ : there isn’t Suckling/ Disturb milk ejection ALVEOLI produced continuesly & full filed Raising of mammary gland tension b/ There isn’t Suckling/ Distrubed Tension will grow up reached Max point MILK SEKRETION DELAYED

29. 1. Time must constant squezing 2. Sound of bucket 3. There is a Calf 4. Washing of Mammary 5. Look at food (Habitualis) 6. Genital Manipulation 7. Matting 8. R/ Oxytocin eksogen 9. Electrical Stimulate for Tractus Supraoptico-Hipofisialis

30. = Basket, Arround of Alveoli It’s. Efector contractile tissue It’s Cells with stuck out, branch off & not Arranged Can Contraction with R/ : Local Oksitocyn/ Vasopresin, Histamin, Asetilcholine & Philocarpine