Presentation on theme: "MALIGNANCIES OF THE HAEMAPOIETIC STEM CELL. Haemapoietic Stem Cell are pluripotent and give rise to all of the haemopoietic cell under the action of cytokines."— Presentation transcript:
Haemapoietic Stem Cell are pluripotent and give rise to all of the haemopoietic cell under the action of cytokines. Stem cell are identified by CD34 positivity and CD117 positivity. CD117 is the receptor for stem cell factor
MYELODYSPLASTIC DISORDERS Abnormal looking haemopoitic cells with < 20% blasts in marrow Refractory cytopaenia with unilineage dysplasia Refractory cytopaenias with multilineage dysplasias Refractory anaemia with ringed sideroblasts Refractory anaemia with excess of blasts.
High Risk MDS Refractory Anaemia with Excess of Blasts Secondary MDS from previous chemotherapy Bad cytogenetics : p53 deletion Chr 17p Complex cytogenetics >/= 3 abnormalities
AML RECURRENT CYTOGENETIC ABNORMALITIES M2 with t(8;21) RUNX1-RUNX1T1 M4 Eos inv 16 (p13.q22) CBFB-MYH11 M3 t(15;17) PML-RARA M4/M5 t(9;11) MLLT3-MLL AML with dysplasia t(6;9) AML with thrombocytosis inv(3)(q21;q26.2) M7 t(1,22)
ACUTE PROMYELOCYTCIC LEUKEMIA Prone to DIC Responds to All-trans retinoic Acid ATRA Responds to low dose Arsenic
ALL RECURRENT CYTOGENETIC ABNORMALITIES B ALL t(9:22) t(12;21) TEL-AML1 or ETV6-RUNX1 t(1;19) t(v;11q23) MLL gene rearranged