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MES-4 Chromatin Regulation in the C. elegans Germ Line
XX XO soma both Xs are reduced ~50% germline Xs are not transcribed Dosage compensation in worms:
How chromatin is organized…
The Histone Code H3 H4 N N H3 N N NN acetylated Lys 8, 12, 16 activating methylated Lys 9 silencing methylated Lys 4, 36 activating methylated Lys 27 silencing methylated Lys 20 silencing
Ref. Get better resolution! Kornberg and Lorch, Cell 1999 H3 H4 H2A H2B The nucleosome.
MES-4 binds to just 5 of the 6 chromosomes. MES-4 + DNA DNA alone maternal pronucleus paternal pronucleus
WT mes-4 WT mes-4 2mK36 H3-Lys36 di-methylation is on Xs in early embryos. MES-4 is required for H3-Lys36 di-methylation. 1-cell
Antibody Use in Detection of Target Protein
NSD1 catalyzes H3 Lys36 and H4 Lys20 methylation in vitro. (Raysam et al., EMBO J 2003) MES-4 and its homologs
C. elegans (MES-4) and C. briggsae (CBG60706) Homologs
MES-4 and CBG60706
CB60706 and MES-4 Introns and Exons
BLAST Amino Acid Alignment Under Default Settings
PowerPoint to accompany Genetics: From Genes to Genomes Fourth Edition Leland H. Hartwell, Leroy Hood, Michael L. Goldberg, Ann E. Reynolds, and Lee M.
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Ch. 18 Regulation of Gene Expression Objectives: LO 3.18 The student is able to describe the connection between the regulation of gene expression and observed.
Central Dogma Protein Synthesis. Two types of nucleic acids # of strands kind of sugar bases used.
Control of gene expression. Every cell has at least one chromosome consisting of a DNA molecule. Each chromosome contains genes – pieces of a DNA molecule.
Regulation of Gene Expression 11. Chapter 11 Regulation of Gene Expression Key Concepts 11.1 Several Strategies Are Used to Regulate Gene Expression 11.2.
Vocabulary Key Terms DNA DNA replication Codon Intron Exon Translation Central Dogma Transcription RNA mRNA tRNA Anticodon Genes Nucleotide Nitrogen base.
Hoover High School Mr.Plazaks Biology : Write an answer here What is the sequence of an RNA molecule produced from transcription of the following DNA.
The packaging of DNA in eukaryotic chromosomes or how you change this µm 4 cm Too small to show the real size, but you could fit 10,000 along.
Epigenetic phenomena Epigenetics refers to genetic inheritance that is not coded by the DNA sequence It includes changes in gene expression due to modification.
IB Topics: DNA, Transcription, Translation (3.3, 3.4, 3.5) 7.1, 7.2, 7.3, 7.4.
How is RNA Transcribed from DNA AP Biology Fall 2010.
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DNA and Cell Reproduction. Structure of DNA Deoxyribonucleic Acid DNA is one of the two nucleic acids –DNA –RNA It is composed of repeating subunits (monomers)
End Show Slide 1 of 39 Copyright Pearson Prentice Hall 12-3 RNA and Protein Synthesis 12–3 RNA and Protein Synthesis.
Slide 1 of 26 Copyright Pearson Prentice Hall Biology.
Chapter 18: Regulation of Gene Expression The functions of the three parts of an operon. The role f repressor genes in operons. The impact of DNA methylation.
Eukaryotic Chromatin Structure 1.Chromatin structure is based on successive levels of DNA packing THE ORGANIZATION AND CONTROL OF EUKARYOTIC GENOMES.
GENE REGULATION Virtually every cell in your body contains a complete set of genes But they are not all turned on in every tissue Each cell in your body.
Chromosomes and gene regulation DNA is just information - a blueprint No use unless you know the rules for using the information DNA is organised (in chromosomes)
Chapter 10. Objectives Compare the structure of DNA and RNA Summarize the process of transcription Outline the major steps of translation SCS:B-4.4.
DNA and RNA What does DNA look like? What are the elements that makeup DNA?
CH. 8 IDENTIFYING DNA AS THE GENETIC MATERIAL. CH. 5 & 6 REVIEW ANSWER THE FOLLOWING QUESTIONS: 1. What macromolecule group does DNA & RNA belong in?
Copyright © 2005 Pearson Education, Inc. publishing as Benjamin Cummings Chapter 18 Regulation of Gene Expression.
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